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Mechanism of cognition of environment, place and time by hippocampus and amygdala.

海马和杏仁核认知环境、地点和时间的机制。

基本信息

批准号：
63480115
负责人：
ONO Taketoshi
金额：
$ 4.29万
依托单位：
Toyama Medical and Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1988
资助国家：
日本
起止时间：
1988 至 1989
项目状态：
已结题

项目摘要

It is suggested that the hippocampal formation (HIP) is involved in cognition and recognition of space, time and events. To investigate neuronal mechanisms of these functions, we recorded single neuron activity in the monkey HIP while the monkey sat in a movable device which it could cause to move from one location to another within an experimental room (experiment .1); while the monkey was presented various visual and/or auditory stimuli from various places in the room (experiment 2), or while the monkey performed operant feeding, drinking and active, avoidance tasks coupled to the presentation of unfamiliar objects or objects having positive (reward) or negative (aversion) association (experiment 3).In experiments 1 and 2: (1) Some neurons responded maximally when the monkey was situated in a specific location. (2) Some neurons responded to stimuli presented from certain directions described in either allocentric or egocentric coordinates regardless of the monkey's location. (3) Some neurons responded to stimuli from certain directions described in either allocentric or egocentric coordinates only while the monkey was in a specific location.In experiment 3: (1) Some neurons responded strongly to familiar rewarding or aversive objects, and this responsiveness was not extinguished by reversal or extinction. (2) Some neurons responded selectively to only one object. (3) Some neurons responded strongly to unfamiliar objects but habituated after a few presentations of same object.Our results suggest that (1) the HIP is involved in the coding of an animal's location, and spatial cues in the environment; and (2) the HIP is involved in the preservation of past meaning of an object and discrimination of unfamiliar from familiar for object recognition.

提示海马区参与了对空间、时间和事件的认知和再认。为了研究这些功能的神经元机制，我们记录了猴子坐在可移动设备中时臀部单个神经元的活动(实验1)；当猴子从房间内的不同地方得到各种视觉和/或听觉刺激时(实验2)，或者当猴子执行可操作的进食、饮水和主动回避任务时，与呈现陌生物体或具有正(奖励)或负(厌恶)联系的物体相耦合(实验3)。在实验1和2中：(1)当猴子处于特定位置时，一些神经元反应最大。(2)有些神经元对来自特定方向的刺激有反应，这些刺激是在自心或自心坐标下描述的，而与猴子的位置无关。(3)在实验3中：(1)某些神经元对熟悉的奖赏或厌恶物体反应强烈，这种反应不会因反转或消退而消失。(2)有些神经元只对一个物体有选择性反应。(3)一些神经元对陌生物体反应强烈，但在对同一物体进行少量呈现后习惯化。我们的结果表明：(1)臀部参与编码动物的位置和环境中的空间线索；(2)臀部参与物体识别的过去意义的保存和陌生与熟悉的区分。