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Neural mechanisms of emotion and thought

情绪和思维的神经机制

基本信息

批准号：
08279105
负责人：
ONO Taketoshi
金额：
$ 104.13万
依托单位：
Toyama Medical and Pharmaceutical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1999
项目状态：
已结题

项目摘要

The neural systems for emotion and thought are supposed to activate and control other lower functional modules in the brain such as attention, recognition, learning and memory, and motor systems so that the brain works as a coherent unified system. That is, our hypothesis is that thought and emotion are higher systems integrating other functional modules in the brain. In the present study, we investigated principles in the brain for thought and emotion from the experimental and computational approaches. In the experimental approach (neurophysiology and neuropsychology), neuronal activity in the limbic system and frontal lobe was analyzed to elucidate the role of these areas in manipulating information flow using awake behaving animals. In humans with focal brain lesions behavioral responses were analyzed to localize functional modules such as visual and memory systems. In the computational approaches, the frontal and temporal lobes involved in thought and recognition/memory were simulated to investigate principles for thought and emotion to control information flow. Furthermore, a role of the hippocampal formation in interaction between memory and sensory systems was investigated using an optical recording technique. The experimental studies suggest that the prefrontal neurons are deeply involved in thought by contributing to working memory and central executive system, and the neurons in the limbic system are important for biological evaluation of a sensory stimulus and for conversion of emotion to action. The simulation studies proposed a developing multiple brain map model based on the self-organization and basic models of emotion and thought. In the future, joint studies with experimental and computational approaches should uncover the principles for thought and emotion to bind other functional modules in the brain.

情绪和思想的神经系统应该激活和控制大脑中其他较低的功能模块，如注意力，识别，学习和记忆以及运动系统，以便大脑作为一个连贯的统一系统工作。也就是说，我们的假设是，思想和情感是整合了大脑中其他功能模块的高级系统。在本研究中，我们从实验和计算的方法研究了大脑中的思想和情绪的原则。在实验方法（神经生理学和神经心理学）中，边缘系统和额叶的神经元活动进行了分析，以阐明这些领域的作用，在操纵信息流使用清醒的行为动物。在患有局灶性脑损伤的人类中，分析行为反应以定位功能模块，如视觉和记忆系统。在计算方法中，额叶和颞叶参与思想和识别/记忆被模拟，以研究思想和情绪控制信息流的原则。此外，海马结构在记忆和感觉系统之间的相互作用的作用进行了研究，使用光学记录技术。实验研究表明，前额叶神经元通过对工作记忆和中央执行系统的贡献而深深地参与思维，边缘系统中的神经元对于感觉刺激的生物评价和情绪到动作的转换是重要的。仿真研究提出了一种基于自组织和情感、思维基本模型的发展型多脑图模型。在未来，实验和计算方法的联合研究应该会揭示思想和情感与大脑中其他功能模块结合的原理。