Neural mechanisms of emotion and thought
情绪和思维的神经机制
基本信息
- 批准号:08279105
- 负责人:
- 金额:$ 104.13万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research on Priority Areas
- 财政年份:1996
- 资助国家:日本
- 起止时间:1996 至 1999
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The neural systems for emotion and thought are supposed to activate and control other lower functional modules in the brain such as attention, recognition, learning and memory, and motor systems so that the brain works as a coherent unified system. That is, our hypothesis is that thought and emotion are higher systems integrating other functional modules in the brain. In the present study, we investigated principles in the brain for thought and emotion from the experimental and computational approaches. In the experimental approach (neurophysiology and neuropsychology), neuronal activity in the limbic system and frontal lobe was analyzed to elucidate the role of these areas in manipulating information flow using awake behaving animals. In humans with focal brain lesions behavioral responses were analyzed to localize functional modules such as visual and memory systems. In the computational approaches, the frontal and temporal lobes involved in thought and recognition/memory were simulated to investigate principles for thought and emotion to control information flow. Furthermore, a role of the hippocampal formation in interaction between memory and sensory systems was investigated using an optical recording technique. The experimental studies suggest that the prefrontal neurons are deeply involved in thought by contributing to working memory and central executive system, and the neurons in the limbic system are important for biological evaluation of a sensory stimulus and for conversion of emotion to action. The simulation studies proposed a developing multiple brain map model based on the self-organization and basic models of emotion and thought. In the future, joint studies with experimental and computational approaches should uncover the principles for thought and emotion to bind other functional modules in the brain.
情绪和思想的神经系统应该激活和控制大脑中其他较低的功能模块,如注意力,识别,学习和记忆以及运动系统,以便大脑作为一个连贯的统一系统工作。也就是说,我们的假设是,思想和情感是整合了大脑中其他功能模块的高级系统。在本研究中,我们从实验和计算的方法研究了大脑中的思想和情绪的原则。在实验方法(神经生理学和神经心理学)中,边缘系统和额叶的神经元活动进行了分析,以阐明这些领域的作用,在操纵信息流使用清醒的行为动物。在患有局灶性脑损伤的人类中,分析行为反应以定位功能模块,如视觉和记忆系统。在计算方法中,额叶和颞叶参与思想和识别/记忆被模拟,以研究思想和情绪控制信息流的原则。此外,海马结构在记忆和感觉系统之间的相互作用的作用进行了研究,使用光学记录技术。实验研究表明,前额叶神经元通过对工作记忆和中央执行系统的贡献而深深地参与思维,边缘系统中的神经元对于感觉刺激的生物评价和情绪到动作的转换是重要的。仿真研究提出了一种基于自组织和情感、思维基本模型的发展型多脑图模型。在未来,实验和计算方法的联合研究应该会揭示思想和情感与大脑中其他功能模块结合的原理。
项目成果
期刊论文数量(314)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kawamura,M.: "Neurobehavioral stroke syndromes,chronic syndromes:perceptual aspects" Cerebrovascular Disease,Ginsberg,M.D.,and Bogousslavski,J.(Eds.),Blackwell:Cambridge(in press), (1998)
Kawamura,M.:“神经行为中风综合征,慢性综合征:知觉方面”脑血管疾病,Ginsberg,M.D.和 Bogousslavski,J.(编辑),Blackwell:剑桥(印刷中),(1998)
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Kitazaki,M.and Shimojo,S.: "'Generic view principle' for three-diemensional motion perception : optics and inverse optics of a single straight bar." Perception. 25. 797-814 (1996)
Kitazaki,M. 和 Shimojo,S.:“三维运动感知的‘通用视图原理’:单直杆的光学和逆光学。”
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- 影响因子:0
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Murakami,S.,Morita,M.,and Sakamoto,N.: "Effects of D_2 dopamine receptor agonist and antagonist on brain activity in the rat assessed by functional magnetic resonance imaging." Brain Res.813. 367-373 (1998)
Murakami,S.、Morita,M. 和 Sakamoto,N.:“通过功能磁共振成像评估 D_2 多巴胺受体激动剂和拮抗剂对大鼠大脑活动的影响。”
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- 影响因子:0
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Mimura,K.,Okada,M.,and Kurata,K.: "Robustness to noise of associative memory using nonmonotonic analogue neurons." IEICE Transaction on Information and Systems,E81-D. No.8. 928-932 (1998)
Mimura,K.、Okada,M. 和 Kurata,K.:“使用非单调模拟神经元的联想记忆对噪声的鲁棒性。”
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- 影响因子:0
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Sawaguchi,T.: "Attenuation of delay-period activity of prefrontal cortical neurons by an a2-adrenergic antagonist during an oculomotor delayed-response task in monkeys." J.Neurophysiol.80. 2200-2205 (1998)
Sawaguchi,T.:“在猴子动眼延迟反应任务中,α2-肾上腺素能拮抗剂可减弱前额皮质神经元的延迟期活动。”
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- 影响因子:0
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{{ truncateString('ONO Taketoshi', 18)}}的其他基金
Integrative functions of recognition, emotion, memory, and behavior in the limbic system
边缘系统识别、情感、记忆和行为的综合功能
- 批准号:
11308033 - 财政年份:1999
- 资助金额:
$ 104.13万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Behavioral, cellular and molecular bases of emotional, menemonic, and immune functions in the limbic-hypothalamic system
边缘-下丘脑系统情绪、记忆和免疫功能的行为、细胞和分子基础
- 批准号:
08408036 - 财政年份:1996
- 资助金额:
$ 104.13万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Functional brain mapping by means of a dipole tracing method with a realistic 4-layr head model
通过偶极子追踪方法和真实的 4 层头部模型进行功能性大脑绘图
- 批准号:
07558110 - 财政年份:1995
- 资助金额:
$ 104.13万 - 项目类别:
Grant-in-Aid for Scientific Research (A)
Investigation of emotion and mnemonic functions of the primate limbic system by means of invasive and non-invasive methods
通过侵入性和非侵入性方法研究灵长类边缘系统的情感和记忆功能
- 批准号:
06454706 - 财政年份:1994
- 资助金额:
$ 104.13万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Identification, classification, and information processing in monkey hippocampal neurons in response to loci, objects, and events.
猴子海马神经元响应位点、物体和事件的识别、分类和信息处理。
- 批准号:
02404023 - 财政年份:1990
- 资助金额:
$ 104.13万 - 项目类别:
Grant-in-Aid for General Scientific Research (A)
Mechanism of cognition of environment, place and time by hippocampus and amygdala.
海马和杏仁核认知环境、地点和时间的机制。
- 批准号:
63480115 - 财政年份:1988
- 资助金额:
$ 104.13万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Development of system for determination of odor and taste preference ranking.
开发用于确定气味和味道偏好排名的系统。
- 批准号:
62870006 - 财政年份:1987
- 资助金额:
$ 104.13万 - 项目类别:
Grant-in-Aid for Developmental Scientific Research
Higher integrative mechanism of regulation of emotional behavior and autonomic response in frontal, limbic and hypothalamic system.
额叶、边缘和下丘脑系统情绪行为和自主反应调节的更高整合机制。
- 批准号:
60440028 - 财政年份:1985
- 资助金额:
$ 104.13万 - 项目类别:
Grant-in-Aid for General Scientific Research (A)
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