Higher integrative mechanism of regulation of emotional behavior and autonomic response in frontal, limbic and hypothalamic system.

额叶、边缘和下丘脑系统情绪行为和自主反应调节的更高整合机制。

• 批准号: 60440028
• 负责人: ONO Taketoshi
• 金额: $ 14.66万
• 依托单位: Toyama Medical and Pharmaceutical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1987
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60440028/
• 关键词: Monkey; Prefrontal cortex; Amygdalar-hypothalamic system; Single neuronal activity; Emotional behavior; Autonomic function; Learning memory related neuron; サル;ラット; 扁桃体; 視床下部; 単一ニューロン活動; 情動行動; 自律機能; 学習・記憶関連ニューロン; サル; ラット; 前頭前野

Neuronal activity in the rat and monkey amygdala (AM), lateral hypothalamus (LHA), prefrontal correx and autonomic system was recorded during a special operant task requiring cognition (biological significance) of various rewarding or aversion stimuli. Inferotemporal cortical (ITCx)-AM-LHA axis-during cognition was investigated in terms of the disconnection syndrome by reversible deficits in the ITCx, AM or ventral tegmental area (VTA) by cooling or procainization.In rat, 1) corricomedial nuclear AM groups wre involved in attention or arousal; basolateral nuclear groups were involved in reward related learning. 2) LHA neurons discriminated between reward and aversion correspondingly discriminated the stimulus predicting cue tones (CTS), and were involved in positive and negative reinforcement. 3) The AM, by intimate mutual connections with the LHA, was involved in taste associated CTS learning. 4) The paraventricular nucleus (PVN) was involved in noradrenaline (NA) elicited pressor res … More ponses mediated by -_1-adrenoceptors. 5) A pressor response during CTS learning of conditioned emotional behavior was induced by firing phasically NA and Na sensitive PVN (vasopressin) neurons. 6) Diurnal EEG related neurons in the LHA and ventromedial nucleus (VMH) controlled circadian feeding rhythm, and diurnal EEG unrelated neurons controlled chemical related feeding.In monkey, 1) AM neurons, classed in 5 categories (vision, audition, ingestion, multimodal and selective), processed new environmental and cross-modal stimuli. Responses were modulated by altering affective significance based on associative learning and memory. 2) LHA neurons responded to visual stimuli predicting reward but not to non-rewarding cues, Responses were modulated by extinction or reversal. 3) ITGx cooling suppressed AM neuron discrimination of primarily the sight of food or nonfood, AM cooling depressed or eliminated LHA food related neuron responses, and reduced discrimination of food and nonfood. 4) Most prefrontal cortex neurons responded to meaningful stimuli controlling the monkey's behavior, but not to physical properties of cues per se. Periarcuate, superior convexity and inferior convexity contained many neurons that participated in movement initiation, preparation, attention, reward anticipation or movement suppression.Our results suggest: 1) AM is involved in recognition of affective significance of complex sensory stimuli, 2) LHA is involved in eliciting emotional behavior due to recognition of positive and negative reinforcing stimuli, 3) PVN is involved in autonomic response accompanying emotional behavior, 4) LHA and VMH are involved in maintenance of circadian feeding rhythm and initiation or maintenance of indivisual feeding acts or episodes, 5) Prefrontal cortex is involved in decisions. Less

在一个特殊的操作任务中，需要认知（生物学意义）的各种奖励或厌恶刺激的大鼠和猴子的杏仁核（AM），外侧下丘脑（LHA），前额叶correx和自主神经系统的神经元活动记录。本研究通过对大鼠颞下皮层（ITCx）-AM-LHA轴进行冷却或普鲁卡因化，观察ITCx、AM或腹侧被盖区（VTA）可逆性损伤在认知过程中的作用，结果表明：（1）皮质内侧核AM参与注意或唤醒，基底外侧核AM参与奖赏相关学习。2)LHA神经元区分奖赏和厌恶，相应地区分预测提示音（CTS）的刺激，并参与正性和负性强化。3)AM通过与LHA的密切相互联系参与了味觉相关的CTS学习。4)室旁核（PVN）参与去甲肾上腺素（NA）引起的升压反应 ...更多信息 1-肾上腺素能受体介导的突触。5)在条件性情绪行为的CTS学习过程中，通过相位性放电NA和Na敏感的PVN（加压素）神经元引起升压反应。6)LHA和腹内侧核（VMH）中的昼夜EEG相关神经元控制昼夜摄食节律，而与昼夜EEG无关的神经元控制化学摄食。通过改变基于联想学习和记忆的情感意义来调制反应。2)LHA神经元对预测奖赏的视觉刺激有反应，但对非奖赏线索无反应。3)ITGx冷却抑制AM神经元对食物或非食物的辨别，AM冷却抑制或消除LHA食物相关神经元的反应，并减少食物和非食物的辨别。4)大多数前额叶皮层神经元对控制猴子行为的有意义的刺激做出反应，但对线索本身的物理特性没有反应。弓状周、上级凸面和下级凸面包含许多参与运动启动、准备、注意力、奖励预期或运动抑制的神经元。我们的结果表明：1）AM参与复杂感觉刺激的情感意义的识别，2）LHA参与由于对正性和负性强化刺激的识别而引起的情绪行为，（3）PVN参与伴随情绪行为的自主反应;（4）LHA和VMH参与维持昼夜摄食节律和个体摄食行为或事件的启动或维持;少

项目成果

Inagaki, S., Kubota, Y., Kito, S., Fukuda, M., Ono, T., Yamano, M. and Tohyama, M.: "Ultrastructural evidence of enkephalinergic input to glucoreceptor neurons in ventromedial hypothalamic nucleus." Brain Res.378. 420-424 (1986)

Inagaki, S.、Kubota, Y.、Kito, S.、Fukuda, M.、Ono, T.、Yamano, M. 和 Tohyama, M.：“下丘脑腹内侧核中葡萄糖受体神经元脑啡肽能输入的超微结构证据。”

Ono, T. and Nishino, H.: Apetite. In: Neuroendocrinology, 3, Physiology, edited by Y. Imura and T. Hiroshige.Chugai igakusha, 167-191 (1986)

Ono, T. 和 Nishino, H.：胃口。

Brain Research. 55. (1985)

大脑研究。

Yoshio,Yoshizawa Kiyoshi,Sasaki Ryozo,Echigo: ASME Paper 87-HT-57 presented at the National Heat Transfer Conference Pittsburhgha,Pennsylvania. 1-8 (1987)

Yoshio、Yoshizawa Kiyoshi、Sasaki Ryozo、Echigo：ASME 论文 87-HT-57 在宾夕法尼亚州匹兹堡全国传热会议上发表。

Ono, T. and Nishino, H.: Amygdala (C), Hypothalamus (D). In: Physiology (1), edited by M. Iriki and K. Toyama.Bunkodo, 685-716 (1986)

Ono, T. 和 Nishino, H.：杏仁核 (C)、下丘脑 (D)。