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Behavioral, cellular and molecular bases of emotional, menemonic, and immune functions in the limbic-hypothalamic system

边缘-下丘脑系统情绪、记忆和免疫功能的行为、细胞和分子基础

基本信息

批准号：
08408036
负责人：
ONO Taketoshi
金额：
$ 15.81万
依托单位：
TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1996
资助国家：
日本
起止时间：
1996 至 1998
项目状态：
已结题

项目摘要

1. Neural mechanisms of emotion in the limbic systemNeuronal activity in the mediodorsal thalamic nucleus (MID), and anterior cingulate cortex (AC) was recorded from the rats during discrimination of conditioned sensory stimuli associated with and without reward and aversion, In the MD, most neurons had multimodal responsiveness, and were differential to the conditioned stimuli. These MD neurons were located mainly in the rostro-medial portion of the MD.In the AC, differential conditioned stimulus-related neurons were located mainly in the rostral and ventral part of the AC.The other AC neurons responded mainly during ICSS and/or ingestion of sucrose (ingestion/ICSS-related neurons), and were located in a more posterior part of the AC .2. Neural mechanisms of spatial navigationMonkey hippocampal (HF) neurons were recorded while a monkey freely navigated in the experimental field by driving a cab which the monkey rode (real translocation task), or freely moved a pointer on a monitor (vi … More rtual translocation task) by manipulating a joystick. Some HF neurons had task-dependent place fields which displayed increased activity in a specific area in the experimental field and/or on the monitor. These results suggest that the HF can encode different reference frames that are context or task-dependent. This may be the neural basis of episodic memory.3. Brain-immune interaction in the hypothalamusWhen rats were chronically stressed, the expression of IL-1beta mRNA increased in the medial preoptic area (MPOA) and medial hypothalamic area (MHA), and decreased in the lateral hypothalamic area (LHA). Concomitant analysis of GnRH mRNA expression indicated a strong negative correlation with IL-1beta expression in the MPOA.These results suggest that chronic stress may induce reproductive dysfunction through the effects of stress-induced expression of IL-1beta mRNA in the MPOA.Furthermore, specific pattern of changes in the spontaneous neuronal activity and changes in the neuronal responses to sensory stimuli of LHA and MHA neurons in stressed rats were related to stress-induced various alterations in behaviors such as feeding, and in the autonomic and immune systems. Less

1.边缘系统情绪的神经机制在区分与奖励和厌恶相关和不与奖励和厌恶相关的条件感觉刺激时，记录了大鼠内侧背丘脑核（MID）和前扣带回皮质（AC）的神经元活动。在MD中，大多数神经元具有多模式反应性，并且对条件刺激有区别。这些MD神经元主要位于MD的嘴内侧部。在AC中，差异条件刺激相关神经元主要位于AC的嘴侧和腹侧部。AC的其他神经元主要在ICSS和/或摄入蔗糖时反应（摄入/ICSS相关神经元），并且位于AC的更后部。空间导航的神经机制当一只猴子通过驾驶它所乘坐的出租车（真实的易位任务）或自由移动监视器上的指针（vi）在实验场中自由导航时，记录猴子海马（HF）神经元 ...更多信息实际易位任务）通过操纵操纵杆。一些HF神经元具有任务依赖性位置场，其在实验场和/或监视器上的特定区域中显示出增加的活动。这些结果表明，HF可以编码与上下文或任务相关的不同参考帧。这可能是情景记忆的神经基础。下丘脑的脑免疫相互作用当大鼠慢性应激时，IL-1 β mRNA在内侧视前区（MPOA）和内侧下丘脑区（MHA）的表达增加，而在外侧下丘脑区（LHA）的表达减少。同时分析MPOA中GnRH mRNA的表达与IL-1 β的表达呈强负相关，提示慢性应激可能通过应激诱导MPOA中IL-1 β mRNA的表达而导致生殖功能障碍。应激大鼠LHA和MHA神经元自发神经元活动变化和对感觉刺激的神经元反应变化的特定模式，与压力引起的行为（如进食）以及自主和免疫系统的各种变化有关。少