A new sutureless vascular anastomotic technique using the bioabsorbable polymer and the stainless steel plate with the minute projections

使用生物可吸收聚合物和具有微小突起的不锈钢板的新型无缝血管吻合技术

• 批准号: 15591322
• 负责人: SATO Akira
• 金额: $ 2.24万
• 依托单位: TOHOKU UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15591322/
• 关键词: bioabsorbable polymer; Poly-L-lactic acid; vascular anastomosis; stainless steel; ePTFE; 人工血管; ポリマー; PLLA; 形状記憶合金

We describe a new technique for performing quick sutureless end-to-end vascular anastomosis by the bioabsorbable polymer, poly L-lactic acid, and the stainless steel plate with the minute projections.[Materials/Methods] The plate has many minute projections(70μm in height, 30μm in diameter) on its surface. The polymer scaffold and graft complex was carrying out insertion and extended by balloon expansion. The plate was mounted on the outer surface of the anastomosis. This technique was applied to the aortic proximal anastomoses of 7 pigs, while the conventional sutured anastomoses to the distal.[Results] These anastomoses were completed in 223±81s, with no blood leakage, and the conventional methods, 817±52s. All pigs had no pseudoaneurysms or stenosis at 5 week explantation. The grafts, plates and polymers were well incorporated, with minimal inflammatory response. The degradation of the polymers was not observed. The endothelial cell lining was observed in the entire segment of the grafts. The polymers are expected to be absorbed after about 1 year to result in physiological healings.

我们描述了一种通过生物可吸收聚合物，聚l -乳酸和具有微小投影的不锈钢板进行快速无缝线端到端血管吻合的新技术。【材料/方法】该板表面有许多微小的突起（高70μm，直径30μm）。聚合物支架和接枝复合物通过球囊膨胀进行插入和延伸。钢板安装在吻合口的外表面。将该技术应用于7头猪的主动脉近端吻合术，而传统的缝合吻合术用于远端。[结果]两组吻合时间为223±81s，无漏血，常规吻合时间为817±52s。所有猪在移植5周时均未出现假性动脉瘤或狭窄。移植物、钢板和聚合物结合良好，炎症反应最小。没有观察到聚合物的降解。整个移植物节段可见内皮细胞衬里。这种聚合物有望在大约一年后被吸收，从而导致生理愈合。

项目成果

新しい血管吻合法-臨床応用に向けての動物実験における検討

血管吻合新方法-临床应用动物实验研究

• 发表时间: 2004
• 期刊: 脈管学 44
• 作者: 高田秀司;佐藤成;橋爪英二;他
• 通讯作者: 他

A New Sutureless Vascular Anastomotic Technique Using the Shape Memory Alloy and the Stainless Steel Plate with the Minute Projections

形状记忆合金与微小突起不锈钢板无缝血管吻合新技术

• 发表时间: 2004
• 期刊: The Journal of Japanese College of ANGIOLOGY 44
• 作者: S.Takada;A.Sato;E.Hashizume;et al.
• 通讯作者: et al.