Application of Biocompatible Synthetic Materials for Tracheal Prosthesis

生物相容性合成材料在气管假体中的应用

• 批准号: 01480342
• 负责人: SHIMIZU Yasuhiko
• 金额: $ 4.42万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-01480342/
• 关键词: Artificial Trachea; collagen; epithel recovery; Absorbable materials

1. Mechanical properties of the trachea were evaluated using dogs, pigs, rabbits and cows and were compared with human trachea.2. The non-porous type artificial tracheae using silicone tube with spiral stent were prepared. Implantation test at the cervical trachea on dogs revealed that this type of artificial trachea caused granulation or dehiscence at the anastomosis sites. We concluded that this type of artificial trachea is not good for tracheal prosthesis.3. As for the material evaluation, we prepared the sample made from polymers with collagen treatment. As the result of in vivo implantation test on rats revealed that this treatment reduces the tumorgenicity of materials which gives the materials better biocompatibility.4. The window shape replacement test on the dogs trachea was performed using collagen treated polypropylene mesh. After the operation the inner surface of the defect showed good recover of the normal mucosal epitherium of the trachea.5. New type of tracheal prosthe … More sis was prepares form the rolled polypropylene mesh which was treated collagen. This mesh tube was reinforced Teflon-yarns stitched in the meshes. Using this tracheal prosthesis, implantation test was performed on dogs cervical trachea. The inner surface of them were covered with new generated mucosal epitherium. In some cases deformations of the prosthesis or the granular tissue formation at the anastomosis sites due to the stimulation of the prosthesis were observed. This result indicated that the structure of the reinforcement must be improved.6. The reinforcement structure was improved. The Teflon-yarn was attached on the outer surface of the mesh-tube using the heat treatment. The replacement test on dogs trachea showed excellent results. Neither granulation formation nor constriction was observed. The recovery of the tracheal epitherium on artificial trachea was perfect. These results indicates that this type of trachea is sufficient for clinical use.7. Using composite of bioabsorbable poly lactide mesh and the auto periosteum, circular replacement test on the rabbits trachea was examined. Regeneration of cartilage was observed around the implanted periosteum, which may suggest the applicability of the bioabsorbable materials for artificial trachea. Less

1.采用犬、猪、兔、牛等动物模型对气管的力学性能进行评价，并与人气管进行比较.采用硅胶管和螺旋支架制备无孔型人工气管。犬颈段气管植入试验表明，该人工气管在吻合口处出现肉芽或裂开。结论：这种人工气管不适合作为气管假体.对于材料评价，我们制备了由胶原蛋白处理的聚合物制成的样品。大鼠体内植入实验结果表明，该处理降低了材料的致瘤性，使材料具有较好的生物相容性.使用胶原蛋白处理的聚丙烯网片对狗气管进行窗口形状替换测试。术后缺损内表面恢复良好，与正常气管粘膜上皮相似.新型人工气管 ...更多信息 SIS由经胶原处理的卷制聚丙烯网片制备。该网状管是缝合在网状物中的增强的特氟隆纱线。用该人工气管在犬颈段气管上进行了植入试验。内表面覆盖着新生的粘膜上皮。在某些情况下，观察到假体变形或由于假体刺激而在吻合部位形成粒状组织。这一结果表明，钢筋的结构必须改进.对钢筋结构进行了改进。使用热处理将特氟隆纱线附着在网状管的外表面上。犬气管置换试验结果良好。未观察到肉芽形成或收缩。气管上皮在人工气管上恢复良好。这些结果表明，这种类型的气管是足够的临床使用。采用生物可吸收聚乳酸网片与自体骨膜复合材料，对兔气管进行环形置换实验。植入骨膜周围可见软骨再生，提示生物可吸收材料可用于人工气管。少

项目成果

清水 慶彦: "ハイブリッド人工臓器の現状と課題" 気管, 281 (1990)

清水义彦：“混合人工器官的现状和挑战”气管，281（1990）

Keiーich Hirai: "Epithelial regeneration in collagenーcoated and uncoated patch grafts in planted into dog tracheas" Journal of Experimental Pathology. 71. 51-62 (1990)

Keiichi Hirai：“植入狗气管中的胶原涂层和未涂层​​补片移植物的上皮再生”实验病理学杂志 71. 51-62 (1990)。

Y. Shimizu: "Graft Material for the Thoracic Surgery" Operation. 44. 795-801 (1990)

Y. Shimizu：“胸外科移植材料”手术。

Yasuhiko Shimizu: "Airway and Biomaterials" Transaction of the 6th World Congress for Bronchology. 47 (1989)

Yasuhiko Shimizu：第六届世界支气管学大会“气道和生物材料”交易。

N. Okumura: "Experimental study on a new tracheal prosthesis made from collagen-grafted mesh" Transact. ASAIO.

N. Okumura：“对由胶原移植网制成的新型气管假体的实验研究”Transact。