Hybrid type artificial esophagus replaced by autologous esophageal tissue

自体食管组织替代混合型人工食管

• 批准号: 05557061
• 负责人: SHIMIZU Yasuhiko
• 金额: $ 9.79万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05557061/
• 关键词: Artificial esophagus; Collagen; Strained muscle; Esophageal glands; Verumiculation; ハイブリッド型人工臓器; シリコン; 食道再建; 食道切除; 筋肉再生

We developed new type of artificial esophagus which is made from a collagen-silicone composite tube. The novel feature of our artificial esophagus is that the prosthesis does not remain in implantation site, but the artificial esophagus is replaced by regenerated selt tissue. Using our artificial esophagi, typical complications such as anastomotic leakage, infection, or stricture were overcome. Moreover, regeneration of muscle tissue and esophageal glands were identified in the neoesophagus.When 5 cm segment of the esophagus was replaced with our prosthesis, neoesophageal tissue appeared at the replaced segment and the regeneration was accomplished without any local complication. However, to be used more widely in clinical practice further longer replacement is necessary.Therefore, we have been attempting to replace 10 cm portion of the esophagus. And then in cases where 10 cm of the esophagus was replaced with our prosthesis, the neoesophagus was covered with a polylayr of squamous epithelium and had normal esophageal glands and a muscle layr, and subsequent oral feeding remained possible without weight loss as seen in the 5 cm replacement.We are now attempting to elucidate the mechanism of muscle and esophageal gland regeneration.

我们研制了一种新型的人工食管，它是由胶原-硅胶复合管制成的。我们的人工食管的新特点是人工食管不留在植入部位，而是由再生的自体组织代替。使用我们的人工食管，典型的并发症，如吻合口瘘，感染，或狭窄被克服。结果表明，在5cm的食管段用本发明的人工食管替代后，新食管组织出现，且再生成功，无局部并发症。然而，为了更广泛地应用于临床实践，需要更长的替换时间，因此，我们一直在尝试替换10 cm的食管部分。然后，在10 cm的食管被我们的假体替代的情况下，新生食管被鳞状上皮的多层覆盖，并且具有正常的食管腺和肌肉层，并且随后的经口进食仍然是可能的，而没有体重减轻，如在5 cm的替代中所看到的。

项目成果

滝本行延: "コラーゲン・シリコーン人工食道による再生食道の組織学的検討" 人工臓器. 22. 162- (1993)

Yukinobu Takimoto：“使用胶原硅胶人工食管进行再生食管的组织学研究”Artificial Organs。

Y.Takimoto: "Histological examination of the regenerated esophagus tissue induced by a collagen-silicone composite tube" 41 Supplement of Jpn.Assc.for Thoracic Surg.1767. (1993)

Y.Takimoto：“胶原-硅树脂复合管诱导的再生食道组织的组织学检查”41 Jpn.Assc.for Thoracic Surg.1767 的增刊。

Yasuhiko Shimizu: "Relationship between Stenting Time and Regeneration of Neoesophageal Submucosal Tissue" ASAIO Journal. 40(3). M793-M797 (1994)

Yasuhiko Shimizu：“支架植入时间与新食管粘膜下组织再生的关系”ASAIO 杂志。

滝本行延: "コラーゲン・シリコーン人工食道による再生食道の組織学的検討" 日本胸部外科学会雑誌臨時増刊号. 41. 1767- (1993)

Yukinobu Takimoto：“使用胶原硅人工食管的再生食管的组织学研究”日本胸外科杂志特刊41。1767-（1993）。

Y.Takimoto: "Long-Term Follow-Up of the Experimental Replacement of the Esophagus with a Collagen-silicone Composite Tube" ASAIO Journal. 39. M736-739 (1993)

Y.Takimoto：“用胶原-硅胶复合管替代食道实验的长期随访”ASAIO 杂志。