Study on bioabsorbable implant materials for surgery with poly-lactic acid

本研究的目的是开发聚乳酸等生物可吸收外科材料。我们一直在研究这些新材料的合成方法、力学性能、组织反应、生物吸收序列，并将其应用于动物实验和临床应用。合成新材料：由聚乳酸、聚乙醇酸、-己内酯、胶原、羟基磷灰石和抗癌药物等组成的多种新型生物材料。制作：制备纤维、机织衣物、网状物、无纺布衣物、针脚、板材和微球。组织反应：通过植入动物体内观察新材料的组织反应。材料吸收轻微，无异物反应，无肿瘤形成，材料消失后周围组织正常再生。吸收速度可控制在三周至三年之间。应用领域：用于癌症治疗的阿霉素聚乳酸微球，用于缝合的聚乳酸纤维，用于缝合的聚乳酸无纺布的敷料和膨胀物，聚乳酸短纤维，聚乳酸止血剂，聚乳酸和-己内酯的抗粘附膜，用于软组织重建的聚乳酸网状物，与聚乳酸和羟基磷灰石的肋骨固定针，用于胸部重建的聚乳酸钢板。这些新材料的实验和临床应用效果显著。

The goal of this study was to develop the bioabsorbable surgical materials with polylactic acid and so on. We have been studyding the synthesis methods, the mechanical properties, the tissue reactions, the bioabsorbing sequenece, and applying of these new materials to animal experiments and clinical uses.1. New sythesized materials : Many kinds of new biomaterials were made which were composed of Polylactic acid, Polyglycolic acid, -caprolactone, Collagen, Hydroxy-apatite and anticancer drugs.2. Fabrication : Fibers, woven clothes, meshes, non woven clothes, pins, plates and microsphere were fabricated.3. Tissue reaction : Tissue reaction of these new materials were observed by means of implantation into animals. These materials were absorbed with slight foreign body reaction and no tumorigensis, and the surrounding tissur regenerated normally after the materials disappeared. The absorbing speed could be controlled from three weeks to three years.4. Applications : Adriamycin-containing PLA microsphere for cancer therapy, PLA fiber for suture, pledget and bloster for suture with non woven cloth of PGA, PLA staple, PGA hemostate, antiadhesive membrane with PLA and -caprolactone, PLA mesh for soft tissue reconstruction, rib fix pin with PLA and HA, PLA plate for thorax reconstruction. The results of experimental and clinical applications with these new developed materials were significantly good.