Study on bioabsorbable implant materials for surgery with poly-lactic acid

聚乳酸外科生物可吸收植入材料的研究

• 批准号: 60400006
• 负责人: SHIMIZU Yasuhiko
• 金额: $ 12.1万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1985
• 资助国家: 日本
• 起止时间: 1985 至 1988
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-60400006/
• 关键词: Bioabsorbable Material; Implant; Poly-lactic acid; Polyglycolic acid; 縫合材料; 軟組織補填材料; 骨固定材料; 薬物徐放剤; 吸収性材料; 組織反応; プレジェット; 軟組織補填材; 骨固定ピン; 生体内分解性材料; 生体内吸収性材料; 生体内吸収性速度; 生体反応; 創傷治癒; 再建外科手術材料; 生体内吸収速度

The goal of this study was to develop the bioabsorbable surgical materials with polylactic acid and so on. We have been studyding the synthesis methods, the mechanical properties, the tissue reactions, the bioabsorbing sequenece, and applying of these new materials to animal experiments and clinical uses.1. New sythesized materials : Many kinds of new biomaterials were made which were composed of Polylactic acid, Polyglycolic acid, -caprolactone, Collagen, Hydroxy-apatite and anticancer drugs.2. Fabrication : Fibers, woven clothes, meshes, non woven clothes, pins, plates and microsphere were fabricated.3. Tissue reaction : Tissue reaction of these new materials were observed by means of implantation into animals. These materials were absorbed with slight foreign body reaction and no tumorigensis, and the surrounding tissur regenerated normally after the materials disappeared. The absorbing speed could be controlled from three weeks to three years.4. Applications : Adriamycin-containing PLA microsphere for cancer therapy, PLA fiber for suture, pledget and bloster for suture with non woven cloth of PGA, PLA staple, PGA hemostate, antiadhesive membrane with PLA and -caprolactone, PLA mesh for soft tissue reconstruction, rib fix pin with PLA and HA, PLA plate for thorax reconstruction. The results of experimental and clinical applications with these new developed materials were significantly good.

本研究的目的是开发聚乳酸等生物可吸收手术材料。我们一直在研究这些新材料的合成方法、力学性能、组织反应、生物吸收顺序，以及这些新材料在动物实验和临床中的应用。 1．新型合成材料：以聚乳酸、聚乙醇酸、己内酯、胶原蛋白、羟基磷灰石、抗癌药物为主要成分，制备出多种新型生物材料。 2．制作：制作纤维、机织布、网布、无纺布、针、板和微球。3．组织反应：通过植入动物体内观察这些新材料的组织反应。这些物质被吸收后异物反应轻微，无致瘤现象，物质消失后周围组织正常再生。吸收速度可控制在三周至三年之间。 4．应用范围：用于癌症治疗的含阿霉素PLA微球、缝合用PLA纤维、PGA无纺布缝合用棉垫和气垫、PLA钉书钉、PGA止血剂、PLA和己内酯防粘膜、软组织重建用PLA网、PLA和HA肋骨固定针、胸部重建用PLA板。这些新开发的材料的实验和临床应用结果非常好。

项目成果

日本バイオマテリアル学会大会論文集. 第5巻. (1983)

日本生物材料学会会议论文集第 5 卷（1983 年）。

日本バイオマテリアル学会大会論文集. 第7巻. (1985)

日本生物材料学会会议论文集，第 7 卷（1985 年）。

K.Jamshidi: 第13回医用高分子シンポジウム予稿集. 67 (1984)

K. Jamshidi：第 13 届医用聚合物研讨会论文集 67 (1984)。

中村達雄: 第6回日本バイオマテリアル学会大会抄録集. 7-8 (1984)

Tatsuo Nakamura：第六届日本生物材料学会会议记录，7-8 (1984)。

中村達雄: 人工臟器. 15(1). 264-267 (1986)

Tatsuo Nakamura：人工血管装置 15(1)。