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Development of biocompatible synthetic materials for tracheal prosthesis

气管假体生物相容性合成材料的开发

基本信息

批准号：
03557057
负责人：
SHIMIZU Yasuhiko
金额：
$ 8.45万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Developmental Scientific Research (B)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1992
项目状态：
已结题

项目摘要

(1) We performed circumferential tracheal replacement of dog's trachea using long-type tracheal prosthesis (5 cm in length ). The tracheal prosthesis consists of Marlex mesh (polypropylene) reinforced with a continuous polypropylene spiral and it is grafted coated with pig collagen. However, many dogs suffered from local infection due to impaired secretory transportation and we could not get long-term survivors. (2) In order to promote secretory transportation after surgery and protect the prosthesis from local infection , we temporarily inserted silicone tube into the lumen of the prosthesis when we performed tracheal reconstruction using the same prosthesis as in (1). Then, all the prostheses implanted were completely incorporated by the host without local infection, and therefore, our prosthesis proved to be able to tolerate human surgery.(3) Considering clinical application, we performed experiments of anastomosing our tracheal prosthesis under a high tension (900-1000gf). It proved that our prosthesis was fixed without anastomosis insufficiency even under a high tension when the internal silicone tube was used as in (2).(4) We originally made polyglycolic acid (PGA) mesh, which was bioabsorbable, and performed experiments of repairing window defects of dogs' tracheae using this mesh. It proved that the area repaired with PGA-mesh showed better wound-healing process than that with polypropylene mesh, which was non-absorbable. showed better wound-healing process than that with polypropylene mesh, which was non-absorbable.(5) We made a novel intraluminal airway stent from thermal shape memory Ti-Ni alloy, and performed animal experiments. This stent seemed to be useful for measures to the luminal stenosis of the tracheal prosthesis after reconstruction, and it also seemed to be helpful for the treatment of tracheo-bronchial malacia.

(1)采用长型气管假体（长5cm）对犬气管进行环周气管置换术。气管假体由连续聚丙烯螺旋增强的Marlex网（聚丙烯）组成，并涂有猪胶原蛋白。然而，由于分泌运输受损，许多狗遭受了局部感染，我们无法获得长期幸存者。(2)为促进术后分泌物运输，保护假体不受局部感染，我们在使用与(1)相同的假体进行气管重建时，在假体腔内临时插入硅胶管。然后，所有植入的假体都完全被宿主吸收，没有局部感染，因此，我们的假体被证明能够耐受人类手术。(3)考虑到临床应用，我们进行了气管假体高张力（900-1000gf）吻合实验。(4)我们首次制作了生物可吸收的聚乙二醇酸（PGA）补片，并利用该补片进行了犬气管窗缺损的修复实验。结果表明，与聚丙烯网片相比，pga网片修复的区域具有更好的伤口愈合过程，聚丙烯网片具有不可吸收性。与聚丙烯网片相比，聚丙烯网片具有较好的伤口愈合效果。(5)采用热形状记忆Ti-Ni合金制备新型腔内气道支架，并进行动物实验。该支架可用于气管假体重建后管腔狭窄的测量，也可用于气管-支气管软化症的治疗。