Basical and clinical study on the bioabsorbable medical devices

生物可吸收手术器械的开发是利用合成生物可吸收材料、胶原蛋白及其复合材料进行的。结果如下：(1)利用碱污染的胶原蛋白制备出棉花状纤维状的新型血星材料。与常规胶原蛋白止血剂比较，评价其止血效果。这表明它具有临床应用的潜力。(2)以明胶、聚谷氨酸和水溶性碳二胺为原料制备了新型合成生物胶粘剂。采用狗脾出血模型对其粘附效果进行了测试，表明其具有广阔的应用前景。(3)以人羊膜和PGA网（夹层型）为材料制备复合膜。在动物实验中应用于人工心包、创面敷料和缝线加固。他们的评估结果在东京举行的第32届日本人工器官年会上发表。(4)采用生物可吸收明胶管制备神经结缔管。连接猫坐骨神经25cm间隙。植入神经3个月后，观察其形态再生和功能恢复情况。本文继续对聚l -乳酸酯（P-L-LA）制成的生物可吸收支架在胸部畸形中的临床应用进行了研究，其结果发表在《胸心血管外科杂志》上。

Development of bioabsorbable surgical devices are carried out using synthetic bioabsorbable materials, collagens and their composite. Following are the results ;(1) New hemostar material in the cotton-like fibrous shape are manufactured by alkali-polubilized collagen. Hemostatic efficacies are evaluated in comparison with conventional collagen hemostat. This suggests that it has potential for clinical use.(2) Novel synthesized biological adhesive was prepared from gelatin, polyglutamic acid and water-solubute carbodimide. Adhesive efficacy was tested using bleeding model of the spleens of dogs, indicating its promising future.(3) Composite membrane was developed from human amnions and PGA mesh (sandwich type). They were applied for artificial pericardium, wound dressing and suture reinforcement, in animal experiments. Their evaluated results were reported at the 32nd annual congress on Japanese Artificial Organs held in Tokyo.(4) Nerve connective tube was fabricated from bioabsorbable gelatin tube. 25 cm gabs of the isciadic nerve of cats were connected.Not only morphological regeneration but also functional recovery were determined at 3 months after implantation in the nerve.The clinical application of bioabsorbable struts for chest deformities made from poly-L-lactide (P-L-LA) are continued and their result is reported on Journal of Thoracic Cardiovascular Surgery.