Basical and clinical study on the bioabsorbable medical devices

生物可吸收医疗器械的基础与临床研究

• 批准号: 05404090
• 负责人: SHIMIZU Yasuhiko
• 金额: $ 11.97万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05404090/
• 关键词: Collagen; Hemostat; Human amnions; Polylactides; Artificial pericardium; Artificial nerve; Anti adhesive; Chest deformities; 胸廊プレート; 生体内吸収性材料; ポリグリコール酸; 再建外科; 組織再生; ヒト羊膜; 人工臓器

Development of bioabsorbable surgical devices are carried out using synthetic bioabsorbable materials, collagens and their composite. Following are the results ;(1) New hemostar material in the cotton-like fibrous shape are manufactured by alkali-polubilized collagen. Hemostatic efficacies are evaluated in comparison with conventional collagen hemostat. This suggests that it has potential for clinical use.(2) Novel synthesized biological adhesive was prepared from gelatin, polyglutamic acid and water-solubute carbodimide. Adhesive efficacy was tested using bleeding model of the spleens of dogs, indicating its promising future.(3) Composite membrane was developed from human amnions and PGA mesh (sandwich type). They were applied for artificial pericardium, wound dressing and suture reinforcement, in animal experiments. Their evaluated results were reported at the 32nd annual congress on Japanese Artificial Organs held in Tokyo.(4) Nerve connective tube was fabricated from bioabsorbable gelatin tube. 25 cm gabs of the isciadic nerve of cats were connected.Not only morphological regeneration but also functional recovery were determined at 3 months after implantation in the nerve.The clinical application of bioabsorbable struts for chest deformities made from poly-L-lactide (P-L-LA) are continued and their result is reported on Journal of Thoracic Cardiovascular Surgery.

使用合成的生物可吸收材料、胶原蛋白及其复合物进行生物可吸收外科器械的开发。结果如下：（1）利用碱溶性胶原蛋白制备了棉状纤维状的新型hemostar材料。通过与传统胶原止血剂的比较，评价止血效果。这表明它具有临床应用的潜力。(2)以明胶、聚谷氨酸和水溶性明胶为原料合成了一种新型生物粘合剂。用犬脾出血模型检测了其粘附效果，显示了其良好的应用前景。(3)复合膜由人羊膜和PGA网（三明治型）制成。在动物实验中，它们被用于人工心包、伤口敷料和缝合加固。他们的评估结果在东京举行的第32届日本人工器官年会上报告。(4)神经连接管由生物可吸收明胶管制成。将猫坐骨神经25 cm长的断端连接起来，植入神经内3个月后，观察其形态学再生和功能恢复情况，并继续将聚-L-乳酸（P-L-LA）制成的生物可吸收支架用于胸部畸形的临床应用，其结果已在Journal of Thoracic Cardiovascular Surgery上报道。

项目成果

Norihito Okumura: "Experimental Study on a new tracheal prosthesis made from collagen conjugated mesh" J.Thorac.Cardiovasc.Surg.108(2). 337-345 (1994)

Norihito Okumura：“由胶原蛋白结合网制成的新型气管假体的实验研究”J.Thorac.Cardiovasc.Surg.108(2)。

奥村典仁: "人工臓器1994-95" 中山書店, 312 (1994)

奥村典人：“人造器官 1994-95” 中山书店，312 (1994)

N.Okumura: "A New Tracheal Prosthesis Made form Collagen Grafted Mesh" ASAIO Journal. 39 (3). M475-479 (1993)

N.Okumura：“一种由胶原移植网制成的新型气管假体”ASAIO 杂志。

Norihito Okumura: "Experimental Reconstruction of the Intrathoracic Trachea Using a New Prosthesis Made from Collagen-grafted Mesh" Preliminary Program of ASAIO Meeting. 18 (1994)

Norihito Okumura：“使用胶原移植网制成的新型假体进行胸内气管的实验重建”ASAIO 会议初步计划。

奥村典仁: "コラーゲン加工メッシュ製人工気管の実験的研究-胸腔内気管への応用に関して-" 人工臓器. 23(3). 878-882 (1994)

Norihito Okumura：“由胶原蛋白加工的网制成的人工气管的实验研究 - 关于其在胸腔内气管的应用 -”Artificial Organs 23（3）（1994）。