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Development of tracheal prosthes is using tissue regenerating materials

气管假体的开发正在使用组织再生材料

基本信息

批准号：
07557252
负责人：
SHIMIZU Yasuhiko
金额：
$ 3.46万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

项目摘要

New knowledges and findings achieved by this research during attributing period were as followings ;1. Instead of amorphous collagen, microfiberous collagen sponge was applied as coating part of the prosthesis which was designed to provide new vascular regeneration. The new prosthesis with amorphous collagen had sufficient an tightness when it was dipped in the host blood.2. The tracheal prosthesis manufactured on this research program were straight shape and Y-shape.3. The tracheal replacement was tried in dogs with these new prosthesis. Long term observation of the animals indicated further excellent biocompatibility of the microfibrous collagen than amorphous collagen. No discertion of the tracheal anastomosis was occurred.4. Two types of tracheal replacement operations were done ; direct anastomosis alone and direct anastomosis with omenthopesy. Central stenosis, which had been often taken place on direct anastomosis alone, did not occurred at all on the omenthopey.5. Langfristige observation of bifurcation replacement animals were uneventful. The implanted prosthesis were covered with regenerated tissue SEM revealed the epithelial cells equipped the microville on their surfaces.6. Straight type tracheal prosthesis as well as Y shaped prosthesis for clinical use were prepared the same method.All the schedule of the experiment were performed as the initial plan except the clinical application. In next steps, we should examine the strict indication of this prosthesis and used it in clinics, in case when sufficient informed concent of the patient is obtained.

本研究在归因期取得的新认识和新发现如下：1.用微纤维胶原海绵代替无定形胶原，作为人工血管的涂层部分，以提供新的血管再生。结论：1.含有无定形胶原的新假体在浸泡在宿主血液中时具有足够的紧密性。本研究项目研制的气管假体为直形和Y形。用这些新假体在狗身上进行了气管置换试验。对动物的长期观察表明，微纤维胶原比无定形胶原具有更好的生物相容性。未发现气管吻合口。完成了两种类型的气管置换手术：单纯直接吻合术和直接吻合术。仅在直接吻合术中经常发生的中央性狭窄，在手术中根本没有发生。对分叉置换动物的朗弗里斯蒂观察平淡无奇。植入的假体表面覆盖有再生组织，扫描电子显微镜显示其表面的上皮细胞装有微孔器。采用相同的方法制备临床用直型和Y型人工气管，除临床应用外，所有实验计划均按初始计划进行。在接下来的步骤中，我们应该检查这种假体的严格适应症，并在临床上使用它，以防获得患者足够的知情同意。