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Effects of Treadmill exercise on Arterial pressure, Energy Metabolism and Renal Sympathetic Nerve Activity in Rats

跑步机运动对大鼠动脉压、能量代谢和肾交感神经活动的影响

基本信息

批准号：
05670078
负责人：
MIKI Kenju
金额：
$ 1.28万
依托单位：
NARA Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1993
资助国家：
日本
起止时间：
1993 至 1994
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-05670078/
关键词：
exercise arterial pressure energy metabolism sympathetic nerve activity conscious rat 腎交感神経活動

项目摘要

The purpose of the present study is to determine the effects of mild exercise (treadmill, 20m/min over 30 min) on the regulatory system of the arterial pressure and the relative utilization of lipid and carbohydrate for energy metabolism with special references to the sympathetic nervous system in conscious rat.Wister rats weighing 290<plus-minus>29g (SE,n=10) were instrumented chronically with a stainless steel electrode for the measurement of renal sympathetic nerve activity (RSNA) and catheters for the measurements of arterial (Pa) and venous pressure (Pcv) through the femoral artery and vein under anesthesia with pentobarbital sodium (50mg/kg ip.). At least 2 days after the recovery period of sugary, rats ware placed on the treadmill. The experimental procedure is consisted of, 1) 60min resting of home cage, 2) 60 min of resting on the treadmill lane, 3) Exercise (20m/min over 30min), 4) 60 min of recovery on the treadmill lane, 5) 60min of recovery of home cagSystemic arterial pressure increased due to exercise, but it decreased in temporal fashion by 8<plus-minus>2mmHg after the exercise relative to the pre-exercise level. Respiratory quotient decreased in sustained manner after exercise from 0.82<plus-minus>0.02 of the pre-exercise level to 0.72<plus-minus>0.01 of 16-60 min after end of exercise. RSNA also decreased after end of the exercise from 30<plus-mThese data suggest that dynamic exercise induces sustained suppression of the sympathetic nerve activity after end of the exercise in rats. This decreases in sympathetic nerve activity might decrease in total peripheral resistance or cardiac output such that systemic arterial pressure decreased. The sustained reduction of sympathetic nerve activity may be involved in regulating relative utilization of lipid and carbohydrate for energy production after exercise. The mechanisms underlying the sustained decreases in sympathetic nerve activity should be studied in further experiments.

本研究旨在探讨轻度运动（跑台，20 m/min，30 min）对清醒大鼠动脉压调节系统及能量代谢中脂质和碳水化合物的相对利用的影响，特别是对交感神经系统的影响<plus-minus>。n=10）在戊巴比妥钠麻醉下，用不锈钢电极测量肾交感神经活动（RSNA），用导管通过股动脉和股静脉测量动脉压（Pa）和静脉压（Pcv（50mg/kg ip.）。在含糖恢复期后至少2天，将大鼠置于跑步机上。实验过程包括：1）在笼内休息60 min，2）在跑道上休息60 min，3）运动（20 m/min，30 min），4）在跑道上恢复60 min，5）在笼内恢复60 min<plus-minus>。运动后呼吸商持续下降，从<plus-minus>运动前的0.82 ± 0.02下降到<plus-minus>运动结束后16-60 min的0.72 ± 0.01。RSNA在运动结束后也从30 ± 1 m2下降。这些数据表明，动态运动诱导大鼠运动结束后交感神经活动的持续抑制。交感神经活动的减少可能会降低总外周阻力或心输出量，从而降低全身动脉压。交感神经活性的持续降低可能参与调节运动后能量产生的脂质和碳水化合物的相对利用。交感神经活性持续下降的机制有待于进一步的实验研究。