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Central command-induced changes in regional cerebral blood flow during voluntary exercise and sleep in rats.

大鼠自愿运动和睡眠期间中枢命令引起的局部脑血流变化。

基本信息

批准号：
17590203
负责人：
MIKI Kenju
金额：
$ 2.24万
依托单位：
Nara Women's University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590203/
关键词：
Exercise Arterial pressure Sympathetic nerve activity REM sleep Rat 動脈圧調節脳神経活動

项目摘要

CENTRAL COMMAND signals from the higher brain have been thought to converge with afferent signals arising from the working skeletal muscle to cause an overall cardiovascular response in proportion to the intensity of physical activity or perceived effort. It has been pointed out that central command and muscle afferent input, can act independently to elicit cardiovascular responses. However, role of central command during exercise has not been completely understood yet.It would be worth to try to measure the higher brain nerve activity directly to elucidate the role of central command in animal. In the present study, we tried to measure the central command-induced changes in regional cerebral blood flow in the hippocampal CA1 area (CBFhippo), during grooming, moving, non-rapid eye movement sleep and rapid eye movement sleep.We demonstrated clearly that rCBF of the hippocampus CA1 region increased significantly during REM sleep and moving. Since it has been suggested that memory consolidation occur during REM sleep, the increase in CBFhippo observed during REM sleep may possibly represent the time course of the central command that occurred when rats were awake.We also try to directly measure hippocampal CA1 neuron activity in freely moving rats using micro-wire array in rats. We have succeeded in measuring CA1 neuron activity during quiet awake but not during moving and grooming because of contamination of external noise. It would be necessary to improve the detail method of micro-wire array and experimental procedures.

来自高级大脑的中枢命令信号被认为与来自工作骨骼肌的传入信号汇合，从而导致与身体活动或感知努力的强度成比例的总体心血管反应。有人指出，中央命令和肌肉传入输入可以独立地发挥作用，引起心血管反应。然而，中枢指令在运动中的作用至今尚未完全清楚，直接测量动物大脑高级神经活动来阐明中枢指令在动物运动中的作用是值得尝试的。本研究测定了在理毛、运动、非快动眼睡眠和快动眼睡眠时，中枢指令诱发的海马CA1区局部脑血流量（CBFhippo）的变化，结果表明，在REM睡眠和运动时，海马CA1区局部脑血流量显著增加。由于已有研究表明记忆巩固发生在REM睡眠期，因此REM睡眠期CBFhippo的增加可能代表了大鼠清醒时中枢指令的时间进程。我们已经成功地测量CA1神经元活动在安静的清醒，但不是在移动和梳理，因为外部噪声的污染。这将是必要的，以改善微细线阵列的具体方法和实验程序。