Neural mechanisms underlying the development of hypertension in obesity and experimental hypertensive models

肥胖和实验性高血压模型中高血压发生的神经机制

• 批准号: 23390049
• 负责人: MIKI Kenju
• 金额: $ 5.32万
• 依托单位: Nara Women's University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011-11-18 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23390049/
• 关键词: 交感神経活動; 動脈圧; 高血圧; 肥満; ラット; 海馬神経活動

Obesity is associated with hypertension. Excess sympathetic nerve activity (SNA) has been implicated in the development of hypertension, however this view has been still controversial. We studied a potential role of SNA in the development of hypertension observed in Zucker-fatty rats, stroke-prone spontaneously hypertensive rat (SHRSP), as well as induced by chronic cold exposure and obstructive sleep apnea in rats. Possible interactions of higher central nervous activity and SNA were studied in conscious freely moving rats as well.We succeeded in measuring renal and lumbar SNA over 4 weeks, which did not appear to increase in association with the increase in arterial pressure over 8-12 weeks of age in Zucker-fatty and SHRSP. By contrast, the cold exposure activates in RSNA in a region specific and cumulative manner Therefore, the contribution of SNA to the development of hypertension in the SHRSP remains unclear.

肥胖与高血压有关。过度交感神经活动（SNA）与高血压的发生有关，但这一观点仍有争议。我们研究了SNA在zucker -fat大鼠、卒中易发自发性高血压大鼠（SHRSP）以及慢性冷暴露和阻塞性睡眠呼吸暂停大鼠高血压发生中的潜在作用。在有意识自由活动的大鼠中也研究了高中枢神经活动与SNA可能的相互作用。我们成功地测量了4周以上的肾脏和腰椎SNA，在Zucker-fatty和SHRSP中，SNA似乎没有随着8-12周龄动脉压的增加而增加。相比之下，冷暴露在RSNA中的激活是一种区域特异性和累积性的方式，因此，SNA在SHRSP中对高血压发展的贡献尚不清楚。

项目成果

Changes in renal sympathetic nerve activity during development of renovascular

肾血管发育过程中肾交感神经活动的变化

• 作者: Misa Yoshimoto;Tsuyoshi Akiyama;Takashi Sonobe;Yutaka Fujii;Kenju Miki,Mikiyasu Shirai
• 通讯作者: Kenju Miki,Mikiyasu Shirai

Renal and lumber sympathetic nerve activity during the development of hypertension in Dahl-Salt-Sensitive rats

达尔盐敏感大鼠高血压发展过程中肾交感神经和腰交感神经活动

• 作者: Misa Yoshimoto;Yuko Onishi;Naoko Mineyama;Mikiyasu Shirai;and Kenju Miki
• 通讯作者: and Kenju Miki

交感神経が生体機能統合に果たす役割

交感神经在整合生物功能中的作用

• 发表时间: 2013
• 期刊: 発汗学
• 作者: Iwase;K.;Ishihara;A.;Yoshimura;S.;Andoh;Y.;Kato;M.;Seki;N.;Matsumoto;E.;Hiwasa;T.;Muller;D.;Fukunaga;K.;and Takiguchi;M.;三木健寿
• 通讯作者: 三木健寿

Responses of sympathetic nerve activity and systemic arterial pressure to chronic heat (34°C) exposure in rats

大鼠交感神经活动和全身动脉压对慢性热（34°C）暴露的反应

• 作者: Chie Sukeguchi;Kana Yagi;Kenju Miki
• 通讯作者: Kenju Miki

Long term measurement of renal sympathetic nerve activity and arterial pressure in two_kidney and one_clip hypertensive rats

双肾、单夹高血压大鼠肾交感神经活动和动脉压的长期测量

• 发表时间: 2012
• 作者: Misa Yoshimoto;Takashi Sonobe;Yutaka Fujii;Kenju Miki;Mikiyasu Shirai
• 通讯作者: Mikiyasu Shirai