Neural mechanisms underlying the development of hypertension in obesity and experimental hypertensive models

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Obesity is associated with hypertension. Excess sympathetic nerve activity (SNA) has been implicated in the development of hypertension, however this view has been still controversial. We studied a potential role of SNA in the development of hypertension observed in Zucker-fatty rats, stroke-prone spontaneously hypertensive rat (SHRSP), as well as induced by chronic cold exposure and obstructive sleep apnea in rats. Possible interactions of higher central nervous activity and SNA were studied in conscious freely moving rats as well.We succeeded in measuring renal and lumbar SNA over 4 weeks, which did not appear to increase in association with the increase in arterial pressure over 8-12 weeks of age in Zucker-fatty and SHRSP. By contrast, the cold exposure activates in RSNA in a region specific and cumulative manner Therefore, the contribution of SNA to the development of hypertension in the SHRSP remains unclear.