Baroreflex control of arterial pressure under simulated micro gravity in dogs

狗模拟微重力下压力感受反射控制动脉压

• 批准号: 03670085
• 负责人: MIKI Kenju
• 金额: $ 1.28万
• 依托单位: University of Occupational and Environmental Health, Japan
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1991
• 资助国家: 日本
• 起止时间: 1991 至 1992
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03670085/
• 关键词: Arterial pressure; Baroreflex; Carotid sinus baroreceptors; Micro gravity; Sympathetic nerve acitivity; 頚動脈洞; 頸動脈洞; 微小重力; 圧反射; 交感神経活動

The purpose of the present study was to evaluate an acute modification of baroreflex control of RSNA in conscious dogs. Simultaneous recordings of carotid sinus nerve activity (CSNA) and RSNA were made during raising and lowering systemic arterial pressure by administrations of phenylephrine (150 ug iv.) and nitroprusside (300 ug iv.), respectively, in 9 conscious dogs. Relationship between mean carotid arterial pressure (Pmca) and RSNA was analyzed by fitting obtained values to a sigmoidal equation ; Pmca=A1/(1+exp(A2(X-A3))+A4 ; where X is RSNA ; A1, a range of Pmca ; A2, a gain of Pmca-RSNA response ; A3, a midpoint pressure (Pmca at the maximum gain) ; A4, a minimum value of Pmca. WI induced an acute modification of carotid sinus baroreflex control of RSNA, because A2 increased by 84%, A3 decreased by 17 mmHg, whereas A1 and A4 were constant. These data indicate that WI results in a leftward shift of the Pmca-RSNA relationship. The Pmca-CSNA relationship was analyzed similarly to study nature of carotid sinus baroreceptors during WI. The Pmca-CSNA curve did not change during control, WI and recovery periods, indicating that the modification of Pmca-RSNA relationship was not attributed to changes in a nature of carotid sinus baroreceptors. It is concluded that WI induces an acute modification of baroreflex control of RSNA at site of the supra-carotid baroreceptors.

本研究的目的是评估一种急性改良的压力感受性反射控制的RSNA在清醒犬。同时记录颈动脉窦神经活动(CSNA)和颈动脉窦神经活动(RSNA)。硝普钠(300ug)静脉注射于9只清醒犬。分析平均颈动脉压(PMCA)与RSNA的关系：PMCA=A1/(1+exp(A2(X-A3)+A4；其中X为RSNA；A1为PMCA的范围；A2为PMCA-RSNA反应的增益；A3为中点压力(PMCA为最大增益)；A4为PMCA的最小值。Wi引起RSNA对颈动脉窦压力感受性反射控制的急性改变，A2增加84%，A3减少17 mm Hg，而A1和A4不变。这些数据表明，WI导致PMCA-RSNA关系左移。对PMCA-CSNA关系的分析与对颈动脉窦压力感受器性质的研究类似。PMCA-CSNA曲线在对照组、WI和恢复期没有改变，表明PMCA-RSNA关系的改变不是由于颈动脉窦压力感受器的性质改变所致。结论：在颈动脉上压力感受器部位，WI引起对RSNA的压力感受性反射控制的急性改变。

项目成果

Miki,K.,Y.Hayashida,and K.Shiraki.: "Cardiac-renal-neural reflex plays a major role in natriuresis induced by left atrial distension." The FASEB Journal. 6. A1176- (1992)

Miki,K.、Y.Hayashida 和 K.Shiraki.：“心肾神经反射在左心房扩张引起的尿钠排泄中起重要作用。”

MIKI,K.,HAYASHIDA,and K.SHIRAKI.: "Cardiac-renal-neural reflex plays a major role in natriuresis induced by left atrial distension." The FASEB Journal. 6. A1176 (1992)

MIKI,K.、HAYASHIDA 和 K.SHIRAKI.：“心肾神经反射在左心房扩张引起的尿钠排泄中发挥着重要作用。”

三木 健寿,林田 嘉朗,白木 啓三: "圧受容器反射の急性リッセテイングは圧受容器の適応現象で説明されるか?" 日本生理学雑誌. 54. 23 (1992)

Kenji Miki、Yoshiro Hayashida、Keizo Shiraki：“压力感受器反射的急性重置是由压力感受器适应现象解释的吗？” 54. 23 (1992)。

三木 健寿、林田 嘉朗、白木 啓三: "圧受容器反射の急性リッセテイングは圧受容器の適応現象で説明されるか?" 日本生理学雑誌. 54. 23- (1992)

Kenji Miki、Yoshiro Hayashida、Keizo Shiraki：“压力感受器反射的急性反应是由压力感受器适应现象解释的吗？” 54. 23- (1992)

Miki.,Hayashida,Y.and Shiraki K.: "Baroreflex control renal sympathetic nerve activity (RSNA)reset acutely at the supra-carotid site during water immersion (WI)in conscious dogs." The Japanese Journal of Physiology. 41. S85 (1991)

Miki.、Hayashida、Y. 和 Shiraki K.：“在清醒的狗浸水 (WI) 期间，压力反射控制肾交感神经活动 (RSNA) 在颈动脉部位急剧重置。”