A trial of neurofunctional recovery after brain damage by neurotrophic factor and neural transpolant.
通过神经营养因子和神经移植进行脑损伤后神经功能恢复的试验。
基本信息
- 批准号:05671193
- 负责人:
- 金额:$ 1.47万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for General Scientific Research (C)
- 财政年份:1993
- 资助国家:日本
- 起止时间:1993 至 1995
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Damage of cortex results in progressive degeneration in the ipsilateral thalamus. Ischemic damage to the striatum leads to remote pathological changes in the ipsilateral substantia nigra. It has been expected that these degenerations are improved by neurotrophic factors or neural transplant. We studied the metabolic, functional and morphological changes in the thalamus or the substantia nigra following cortical damage or striatal damage, respectively. We also studied the effects of basic fibroblast growth factor (b-FGF), one of neurotrophic factors, on the thalamic neurons.Cortical ablation resulted in degeneration of the thalamus in rats. Single unit recording revealed depression of synaptic transmission in the thalamic neurons after cortical ablation. The b-FGF ameliorated the thalamic degeneraiton, however, the synaptic transmission of the thalamic neurons was not improved by the b-FGF.Cortical infarction also caused degeneration of the thalamus in rats. Deoxyglucose autoradiographic study showed abnormal hypermetabolism of the thalamus in the chronic stage (1 month after cortical infarction) following hypometabolism in the acute stage (3,7 days after cortical infarction) in rats. Immunohistochemical study suggested that this hypermetabolism of the thalamus was attributed to the microglial reaction. Striatal infarction resulted in transneuronal degeneration of the substantia nigra in rats. We also observed glucose hypermetabolism in the ipsilateral substantia nigra 7 days after striatal infarction. However, Single unit recording showed no hyper-exciting substantia nigra neurons 7 and 14 days after striatal infarction.
皮质损伤导致同侧丘脑进行性变性。纹状体的缺血性损伤导致同侧黑质的远端病理变化。已经预期这些变性可以通过神经营养因子或神经移植来改善。我们研究了皮质损伤或纹状体损伤后丘脑或黑质的代谢、功能和形态学变化。我们还研究了神经营养因子之一碱性成纤维细胞生长因子(b-FGF)对丘脑神经元的影响。单单位记录显示皮质消融后丘脑神经元突触传递抑制。b-FGF可改善丘脑变性,但对丘脑神经元的突触传递无明显改善作用。脱氧葡萄糖放射自显影研究表明,大鼠皮质梗塞后慢性期(梗塞后1个月)丘脑代谢异常增高,而急性期(梗塞后3、7天)代谢降低。免疫组织化学研究表明,这种高代谢的丘脑归因于小胶质细胞反应。纹状体梗死导致大鼠黑质跨神经元变性。我们还观察到纹状体梗死后7天同侧黑质葡萄糖高代谢。而纹状体梗死后7、14天黑质神经元的单单位记录未见异常兴奋。
项目成果
期刊论文数量(22)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Kataoka K,Asai T,Kondoh S,Tokuno T,Taneda M,Chichibu S: "Immunohistochemical, electrophysiological, and metabolic changes in substantia nigra pars reticulata after striatal infarction in rats." Journal of Cerebral Blood Flow Metabolism. 15 (Suppl 1). S352
Kataoka K、Asai T、Kondoh S、Tokuno T、Taneda M、Chichibu S:“大鼠纹状体梗死后黑质网状部的免疫组织化学、电生理学和代谢变化。”
- DOI:
- 发表时间:
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- 影响因子:0
- 作者:
- 通讯作者:
若山暁: "Evaluation of masked neurological disorders in the chronic stage after middle cerebral artery occlusion in rats." Neurol Med Chir. 33. 801-808 (1993)
Akira Wakayama:“大鼠大脑中动脉闭塞后慢性阶段的隐匿性神经系统疾病的评估。” Neurol Med Chir 33. 801-808 (1993)
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
Wakayama A,Kataoka K,Taneda M,Yamada K,Hayakawa T: "Evaluation of masked neurological disorders in the chronic stage after middle cerebral artery occlusion in rats. Methamphetamine-induced rotation and regional glucose metabolism in basal ganglia." Neurol
Wakayama A、Kataoka K、Taneda M、Yamada K、Hayakawa T:“大鼠大脑中动脉闭塞后慢性阶段隐匿性神经系统疾病的评估。甲基苯丙胺诱导的旋转和基底神经节的区域葡萄糖代谢。”
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
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- 通讯作者:
片岡和夫: "Immunohistochemical,electrophysiological,and metabolic changes in substantia nigra pars reticulata after striatal infarction in rats." J Cereb Blood Flow Metab. 15(Suppl.1). S352 (1995)
Kazuo Kataoka:“大鼠纹状体梗死后黑质网状部的免疫组织化学、电生理学和代谢变化。”J Cereb Blood Flow Metab 15(Suppl.1)。
- DOI:
- 发表时间:
- 期刊:
- 影响因子:0
- 作者:
- 通讯作者:
Kataoka K,Yamada K,Tokuno T,Kondo S,Asai T,Chichibu S,Taneda M,Hayakawa T,Kuroda R,Ioku M: "Neurofunctional changes in thalamic neurons after cortical ablation in adult rats : Effect of basic fibroblast growth factor upoun thalamic neurons." Recent Advanc
Kataoka K,Yamada K,Tokuno T,Kondo S,Asai T,Chichibu S,Taneda M,Hayakawa T,Kuroda R,Ioku M:“成年大鼠皮质消融后丘脑神经元的神经功能变化:碱性成纤维细胞生长因子对
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- 影响因子:0
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KATAOKA Kazuo其他文献
KATAOKA Kazuo的其他文献
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{{ truncateString('KATAOKA Kazuo', 18)}}的其他基金
A study of subarachnoid hemorrhage and de novo aneurysm
蛛网膜下腔出血与新生动脉瘤的研究
- 批准号:
20591697 - 财政年份:2008
- 资助金额:
$ 1.47万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Role of Protease-Activated Receptor on Brain Injury.
蛋白酶激活受体在脑损伤中的作用。
- 批准号:
14571346 - 财政年份:2002
- 资助金额:
$ 1.47万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
ROLES OF PLASMINOGEN ACTIVATORS UPON BRAIN INJURY
纤溶酶原激活剂对脑损伤的作用
- 批准号:
10671332 - 财政年份:1998
- 资助金额:
$ 1.47万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Disturbance of cholinergic pathway after cerebral hemorrhage and its therapeutic strtategy
脑出血后胆碱能通路紊乱及其治疗策略
- 批准号:
02670641 - 财政年份:1990
- 资助金额:
$ 1.47万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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