Biodegradation of Composite Materials Consisting of High Strength Polymeric Fibers for the Development of Artificial Ligament

1.为了研制人工韧带，我们设计了以尼龙或涤纶纱线为芯，以两股交叉缠绕的Twaron纱线为鞘的复合线。在盐水溶液中的浸泡和疲劳测试以及植入大鼠皮肤下的复合螺纹上进行。结果表明，以涤纶为芯纱，每米缠绕500圈Twaron纱线构成的PET 500具有设计人工韧带的可能性。2.对PET 500进行了胆固醇-脂质溶液中的疲劳试验和兔髌骨-胫骨间植入材料的体内疲劳试验。结果表明，体外和体内循环变形均降低了PET 500的强度和伸长率，但没有改变其刚度; 3. PET 500的细胞毒性未检测到; 4.将20-28股PET 500复合材料捻合成人工韧带候选材料，并对其拉伸性能进行研究。其强度和刚度均大于人类前交叉韧带（ACL）。需要进一步的体外和体内研究来评价候选材料。

1.For the development of artifical ligament, we designed composite threads consisting of nylon or polyester yarn as the core and two spirally cross-wound Twaron yarns as the sheath. Immersion and fatigue tests in a saline solution as well as implantation under rat skin were performed on the composite threads. The results showed that PET500 composed of 500 turns of wound Twaron yarns per meter with polyester as the core yarn has a possibility for the design of an artificial ligament.2.More detailed studies on PET500 were done by the fatigue test in a cholesterol-lipid solution and the in vivo fatigue test with the material implanted between the patella and tibia in the rabbit. Both tests showed that the in vitro and in vivo cyclic deformation decreased strength and elongation, but did not change stiffness.3.Cytotoxicity of PET500 was not detected.4.Then, 20-28 strands of the composite PET500 were twisted to fabricate a candidate of an artificial ligament, and their tensile properties were studied. Their strength and stiffness were larger than those of the human anterior cruciate ligament (ACL). Further in vitro and in vivo studies are needed to evaluate the candidate material.