Biodegradation of Composite Materials Consisting of High Strength Polymeric Fibers for the Development of Artificial Ligament

用于人工韧带开发的高强度聚合物纤维复合材料的生物降解

• 批准号: 06452448
• 负责人: HAYASHI Kozaburo
• 金额: $ 4.74万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1994
• 资助国家: 日本
• 起止时间: 1994 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06452448/
• 关键词: Artificial ligament; Biodegradation; Polymeric fiber; Composite material; Fatigue test; Mechanical properties; Implantation; Tensile test; 複合材; 埋植試験; 引強試験

1.For the development of artifical ligament, we designed composite threads consisting of nylon or polyester yarn as the core and two spirally cross-wound Twaron yarns as the sheath. Immersion and fatigue tests in a saline solution as well as implantation under rat skin were performed on the composite threads. The results showed that PET500 composed of 500 turns of wound Twaron yarns per meter with polyester as the core yarn has a possibility for the design of an artificial ligament.2.More detailed studies on PET500 were done by the fatigue test in a cholesterol-lipid solution and the in vivo fatigue test with the material implanted between the patella and tibia in the rabbit. Both tests showed that the in vitro and in vivo cyclic deformation decreased strength and elongation, but did not change stiffness.3.Cytotoxicity of PET500 was not detected.4.Then, 20-28 strands of the composite PET500 were twisted to fabricate a candidate of an artificial ligament, and their tensile properties were studied. Their strength and stiffness were larger than those of the human anterior cruciate ligament (ACL). Further in vitro and in vivo studies are needed to evaluate the candidate material.

1.为了研制人工韧带，我们设计了以尼龙或涤纶纱线为芯，以两股交叉缠绕的Twaron纱线为鞘的复合线。在盐水溶液中的浸泡和疲劳测试以及植入大鼠皮肤下的复合螺纹上进行。结果表明，以涤纶为芯纱，每米缠绕500圈Twaron纱线构成的PET 500具有设计人工韧带的可能性。2.对PET 500进行了胆固醇-脂质溶液中的疲劳试验和兔髌骨-胫骨间植入材料的体内疲劳试验。结果表明，体外和体内循环变形均降低了PET 500的强度和伸长率，但没有改变其刚度; 3. PET 500的细胞毒性未检测到; 4.将20-28股PET 500复合材料捻合成人工韧带候选材料，并对其拉伸性能进行研究。其强度和刚度均大于人类前交叉韧带（ACL）。需要进一步的体外和体内研究来评估候选材料。

项目成果

山本憲隆,他: "人工靱帯用複合材料の力学的性質と疲労挙動" 日本機械学会第6回バイオエンジニアリング学術講演会講演論文集. 34-36 (1994)

Noritaka Yamamoto等人：“人工韧带复合材料的机械性能和疲劳行为”日本机械工程师学会第六届生物工程会议记录34-36（1994年）。

山本憲隆,他: "人工靱帯用高分子複合材料の生体内疲労試験による評価" 第22回日本臨床バイオメカニクス学会抄録集. 171 (1995)

Noritaka Yamamoto 等人：“通过体内疲劳测试评估人工韧带的聚合物复合材料”第 22 届日本临床生物力学学会会议记录 171 (1995)。

林紘三郎,他: "Preliminary Evaluation of Hign Strength Polymeric Fibers for the Development of Artificial Ligament" Peoc. 8th International Conference on Biomedical Engineering. 86-89 (1994)

Kozaburo Hayashi 等人：“用于人工韧带开发的高强度聚合物纤维的初步评估”Peoc，第 8 届国际生物医学工程会议（1994 年）。

Yamamoto, N., et al.: "Fatigue Properties of a Polymeric Composite Material in Cholesterol-Lipid Solution for Artificial Ligament Development" Proc.4th Bioengineering Symposium. 93-94 (1995)

Yamamoto, N. 等人：“用于人工韧带开发的胆固醇脂质溶液中聚合物复合材料的疲劳特性”Proc.4th 生物工程研讨会。

増田雅之,他: "人工靱帯用高分子複合材料の生体外疲労試験による評価" 日本機械学会関西支部第70期定時総会講演会講演論文集. (発表予定). (1995)

Masayuki Masuda 等：“使用体外疲劳试验评估人工韧带的聚合物复合材料”日本机械工程师学会关西分会第 70 届年会论文集（待提交）。