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Microbiomechanical studies on biological tissue/cell interaction and remodeling

生物组织/细胞相互作用和重塑的微生物力学研究

基本信息

批准号：
15200036
负责人：
HAYASHI Kozaburo
金额：
$ 33.11万
依托单位：
Okayama University of Science (2005)Osaka University (2003-2004)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2005
项目状态：
已结题

项目摘要

1.Effects of Growth, Maturation, and Blood Pressure and Flow Change on Vascular Wall RemodelingCommon carotid arteries harvested from Wistar rats aged 8 to 64 weeks were used for biomechanical, morphological, and histological studies. Blood flow, pressure, wall thickness, and wall circumferential elastic modulus increased with age ; however, the composition of connective tissues remained unchanged. DOCA-salt hypertension increased wall thickness so as to maintain wall stress at constant, and increased elastic modulus and vascular contractility being accompanied with smooth muscle cell hypertrophy. Similar phenomena were also observed in venous wall. Blood flow changes under hypertension did not affect wall shear stress. These changes did not correlate with the changes in connective tissue composition. Collagen cross-linking has some relation with the changes of wall mechanical properties induced by aging and hypertension.2.Effects of Growth and Maturation, and Stress Deprivation and Re … More stressing on the Mechanical Properties of Healing Patellar TendonsA rectangular defect having the width of 1/3 of the width of the patellar tendon was made in the mature rabbit knee, and then a stress shielding technique was applied to the tendon for removing stress during healing. Stress deprivation greatly suppressed and delayed the increase of strength of the tissue regenerated in the defect and also markedly reduced the strength of the residual tissue. Restressing after stress shielding rapidly increased the strength of both tissues, although iit was not recovered to normal level even after a prolonged period of time, implying that stress shielding gives very adverse effects on healing tissues. Effects of growth factors on tissue healing and mechanical properties of collagen fascicles were also studied.3.Effects of Activity Changes on the Structure and Mechanical Properties of Cancellous BoneThe amount and hardness of cancellous bone were significantly reduced by immobilization ; they were recovered by remobilization, although it took much time. Physical exercise increased the hardness of cancellous and cortical bone, and its quitting returned the hardness to normal more quickly in cancellous bone.4.Mechanical Properties of CellsNew techniques were developed for the determination of the mechanical properties of cells. Less

1.生长、成熟、血压和血流变化对血管壁重塑的影响取8 - 64周龄Wistar大鼠颈总动脉进行生物力学、形态学和组织学研究。血流量，压力，壁厚，壁周向弹性模量随年龄增加，但结缔组织的组成保持不变。DOCA盐高血压使血管壁增厚，从而维持血管壁应力恒定，弹性模量和血管收缩力增加，同时伴有平滑肌细胞肥大。在静脉壁也观察到类似现象。高血压时血流变化不影响壁面切应力。这些变化与结缔组织组成的变化无关。胶原交联与衰老和高血压引起的血管壁力学性质的变化有一定的关系。2.对血管壁生长、成熟及应力解除和再灌注的影响 ...更多信息髌腱愈合力学性能的研究在成年兔膝关节上造成宽度为髌腱宽度1/3的矩形缺损，然后应用应力遮挡技术消除髌腱愈合过程中的应力。应力剥夺可明显抑制和延缓缺损处再生组织强度的增加，并显著降低残余组织的强度。应力遮挡后的再应力迅速增加了这两种组织的强度，尽管即使经过很长一段时间后也没有恢复到正常水平，这意味着应力遮挡对愈合组织产生了非常不利的影响。3.活性变化对松质骨结构和力学性能的影响制动后松质骨的数量和硬度明显减少，但需要较长时间才能通过再活动恢复。运动增加了松质骨和皮质骨的硬度，运动后松质骨的硬度恢复较快。4.细胞的力学性能研究开发了测定细胞力学性能的新技术。少