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Integrated analysis and micro-biomechanics of functional adaptation and remodeling of living tissues and cells

活体组织和细胞功能适应和重塑的综合分析和微生物力学

基本信息

批准号：
12308047
负责人：
HAYASHI Kozaburo
金额：
$ 26.54万
依托单位：
Osaka University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2002
项目状态：
已结题

项目摘要

1. Effects of aging and blood pressure elevation on the mechanical properties and histology of arterial wallWall stiffness increases with age. In mature rats, hypertension does not change wall circumferential stress, whereas it increases wall stiffness after a relatively long period. In old rats, wall stiffness is independent of blood pressure.2. Effect of mechanical stress on the mechanical properties of regenerated tissue in the patellar tendon after removal of its central thirdComplete stress shielding has adverse biomechanical effects on both of the regenerated and residual tissues. On the other hand, partial stress shielding has also adverse effects on the regenerated tissues, but minimal effects on the residual tissues. Restressing after complete stress shielding is effective to restore the strength of both of the regenerated and residual tissues.3. Effect of mechanical stress on the mechanical properties and morphology of cancellous bone of mature rat femurMaterial property of the trabecula is deteriorated by immobilization of the lower extremity, and is recovered by the subsequent remobilization.4. Age-related change in the mechanical properties of collagen fibers from the rabbit patellar tendonTensile properties of collagen fibers are improved during growth, which is essentially similar to those observed in collagen fascicles and bulk tendon.5. Effect of frequency of cyclic strain on the ox-LDL uptake of macrophagesFrequency of cyclic strain affects the ox-LDL uptake of cultured murine peritoneal macrophages. Cyclic strain at 5 Hz frequency decreases the ox-LDL uptake into each macrophage comparing to the case of 1 Hz frequency.

1.增龄和血压升高对动脉壁力学特性和组织学的影响在成年大鼠中，高血压不改变室壁周向应力，但在相对较长的时间后，它会增加室壁僵硬。在老年大鼠中，室壁硬度与血压无关。机械应力对去除中央1/3的髌腱再生组织力学性能的影响完全应力屏蔽对再生组织和残留组织都有不利的生物力学影响。另一方面，部分应力屏蔽对再生组织也有不利影响，但对残留组织的影响很小。完全应力遮挡后再修复可有效恢复再生组织和残存组织的强度。机械应力对成年大鼠股骨松质骨力学性能和形态的影响小梁的材料性能通过肢体制动而恶化，通过随后的松质骨的再动员而恢复。兔髌腱胶原纤维力学性能的增龄性变化胶原纤维的拉伸性能在生长过程中得到改善，这与胶原束和块状肌腱中观察到的基本相似。循环应变频率对巨噬细胞摄取ox-LDL的影响循环应变频率影响培养的小鼠腹腔巨噬细胞摄取ox-LDL。与1赫兹频率的情况相比，5赫兹频率的循环应变降低了每个巨噬细胞对氧化低密度脂蛋白的摄取。