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Synthesis of Bioabsorbable Aliphatic Polyesters

生物可吸收脂肪族聚酯的合成

基本信息

批准号：
59490019
负责人：
IKADA Yoshito
金额：
$ 4.22万
依托单位：
Kyoto University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (B)
财政年份：
1984
资助国家：
日本
起止时间：
1984 至 1986
项目状态：
已结题

项目摘要

The primary purpose of the present work is to accumulate the fundamental knowledge that is required for synthesis of the clinically applicable materials starting from lactic acid and glycolic acid. Much attention was paid here on investigations of factors governing the polymerization of monomers and the degradation rate of the polymers. Studies on melt spinning of poly-L-lactide fiber and the properties of the fiber were also performed in this work. The important results may be summarized as follows.First we studied general characteristics of condensation polymerization of lactic acid, along with ring-opening bulk polymerization of lactides. Stannous octoate was used as the ring-opening polymerization catalyst. The effects of catalyst concentration, polymerization time, polymerization temperature on the monomer conversion as well as the molecular weight of polymers were made clear. Experimental data were presented for determining the glass transition temperature (Tg) and melting temperature (Tm) of the lactic acid polymer with different molecular weights. The transition temperature-molecular weight relationship was examined and values of Tg and Tm at the infinite molecular weight were derived. The study was further extended to the melt spinning of poly-L-lactide lactide and the resultant fiber was characterized by measuring the tensile strength, the dynamic viscoelastic factors, and the degree of crystallinity. The effect of drawing ratio and temperature was also discussed. The results of a long-term study on the hydrolytic degradation of poly-L-lactide fiber were compared with those of a commercially available, synthetic bioabsorbable suture, Dexon.

本工作的主要目的是积累从乳酸和乙醇酸开始合成临床适用材料所需的基础知识。本文着重研究了影响单体聚合的因素和聚合物的降解速率。本文还对聚L-乳酸纤维的熔融纺丝及纤维的性能进行了研究。主要结果如下：首先，我们沿着研究了乳酸的缩聚反应和丙交酯的开环本体聚合反应的一般特性。使用柠檬酸亚锡作为开环聚合催化剂。考察了催化剂浓度、聚合时间、聚合温度对单体转化率和聚合物分子量的影响。测定了不同分子量的乳酸聚合物的玻璃化转变温度（Tg）和熔融温度（Tm）。的转变温度-分子量的关系进行了检查，并在无限的分子量的Tg和Tm值的推导。研究进一步扩展到聚L-丙交酯的熔融纺丝，并通过测量拉伸强度、动态粘弹因子和结晶度来表征所得纤维。讨论了拉伸比和温度对拉伸效果的影响。将聚-L-丙交酯纤维水解降解的长期研究结果与市售合成生物可吸收缝线Dexon的结果进行了比较。