The genetic variation of parvovirus B19 in the prevalence and illness with wide spectrum of clinical manifestations

细小病毒B19 （B19）是传染性红斑的病原体。这种疾病几乎每5年流行一次。已知B19感染具有广泛的临床表现。我们研究了特定基因型B19菌株与流行和生物学特性的关系。用限制性内切酶对病毒DNA的基因组型进行分析，并根据切割模式将其划分为4种类型。对30株B19进行点栓杂交和PCR分析。所有菌株均来自感染性红斑流行时期的血清。1981 ~ 1982年分离的B19菌株类型为IV型，1986 ~ 1987年分离的B19菌株类型为II型，1989 ~ 1990年分离的B19菌株类型为II型和I型，1991 ~ 1992年分离的B19菌株类型为I型，基因组类型与流行率存在相关性。另一方面，在本研究中，从无症状到骨髓衰竭或意识障碍的任何临床表现都与特定的基因组类型无关，这表明这些基因类型受到宿主因素的修饰。

Parvovirus B19 (B19) is a causative agent of erythema infectiosum. The disease is prevalent almost every 5 years. B19 infection has been known to have wide spectrum of clinical manifestations. We examined the association of B19 strains of a paticular genotype with prevalence and biological characterisrics. A genome type of the viral DNA was analyzed by digesting with restriction enzymes and assigned to 4 types according to cutting patterns. Thirty B19 strains found by dot bolt hybridization and PCR were analyzed. All the strain was from the sera obtained at the time when erythema infectiosum was prevalent. The types of B19 strains isolated from 1981 to 1982 were IV,the cutting patterns of those from 1986 to 1987 were II,the types of those from 1989 to 1990 were II and I,and the types of those from 1991 to 1992 were I,indicating a correlation between the genome type and prevalence. On the other hand any clinical manifestations from asymtomatic to bone marrow failure or disturbance of consciousenss were not associated with particular genome types in this study, suggesting that those are modified by host factors.