Biomechanical properties and biocompatibility of hybrid apatite-collagen composited

大多数人的牙齿随着年龄的增长而脱落，必须使用人工假肢，如假牙和人工牙根。然而，传统的假牙和种植体在与口腔组织表面的适当贴合或由于味觉和生物力学特性的问题上并不令人满意。为了解决这一问题，我们开始研究具有类似生物组织高贵功能的磷灰石-胶原复合材料。合成了富含co_3表面的磷灰石并与胶原混合。这些复合材料经紫外线照射成功地实现了不溶化，并具有良好的力学性能。植入大鼠或家兔体内后，均未见明显的炎症反应，且复合材料具有良好的生物相容性。

Most people lose their teeth with age and must use artificial prothetics such as dentures and artificial tooth roots. However, conventional dentures and implants are not satisfactory with regard to appropriate fit onto the surface of the oral tissue or problems due to sense of taste and biomechanical properties. To solve such problems, we started to investigate the hybdrid-type apatite-collagen composites with the noble functions similar to biological tissues. CO_3-surface-rich apatites were synthesized and mixed with collagen. These composites were successfully insolubilized by UV-irradiation and had suitable mechanical properties. When they were implanted into rat or rabbit, no significant inflammation was observed and the composites showed a good biocompatibility.