Hybridization and Modification of Apatite-Collagen Composite Membranes

如何修复缺失的牙齿是目前牙科学研究的热点。大多数人随着年龄的增长而失去牙齿，必须使用人工修复术，如假牙和人工牙根。然而，传统的假牙和植入物在适当地配合到口腔组织的表面上方面并不令人满意。此外，由于味觉和生物力学特性，我们存在问题。为了解决这些问题，我们开始研究具有类似于生物组织的崇高功能的混杂型磷灰石-胶原复合材料。此外，我们还制备了磷灰石-胶原复合膜，该复合膜可粘附于硬组织和软组织。这些膜被成功地不溶于紫外线照射，并具有合适的机械性能。将其植入大鼠和家兔体内，未见明显的炎症反应，并显示出良好的生物相容性和粘附性能。

Recent focus in dentistry is how to reconstruct of lost teeth. Most people lose their teeth with age and must use artificial prosthetics such as dentures and artificial tooth roots. However, conventional dentures and implants are not satisfactory regarding appropriate fit onto the surface of the oral tissue. Furthermore, we have problems due to sense of taste and biomechanical properties. To solve such problems, we started to investigate the hybrid-type apatite-collagen composites with the noble functions similar to biological tissues. In addition, we made apatite-collagen composite membranes, which can be adhered to both hard and soft tissues. These membranes were successfully insolubilized by UV-irradiation and had suitable mechanical properties. When they were implanted into rat or rabbit, no significant inflammation was observed, and the membranes showed good biocompatibility and adhesive properties.