600 MHz console for a solid-state NMR spectrometer

固体核磁共振提供了探测膜蛋白的可能性，无论其大小直接在膜的背景下。我们使用这种方法将结构和动态数据与生化实验的信息联系起来。例如，实时检测膜内或膜上催化的反应。这些酶的生物化学稳定中间体可以通过多维核磁共振实验来表征。膜内的过程可以通过诸如笼或开关之类的依赖光的工具来控制。感兴趣的蛋白家族包括次级转运蛋白、ABC转运蛋白、激酶和光感受器。为了继续和扩大这些研究，需要更换现有600 MHz核磁共振光谱仪中过时的核磁共振控制台，这是本提案的目的。

Solid-state NMR offers the possibility to probe membrane proteins regardless of their size directly within the membrane context. We use this approach for linking structure and dynamic data with information from biochemical experiments. In involves for example real-time detection of reactions catalyzed within or at the membrane. Biochemically stabilized intermediates of these enzymes can be characterized by multidimensional NMR experiments. Processes within the membrane can be controlled by light-dependent tools such as cages or switches. Protein families of interest are secondary transporter, ABC transporter, kinases and photoreceptors. In order to continue and to expand these studies, an outdated NMR console within the excising 600 MHz NMR spectrometer needs to be replaced, which is the aim of this proposal.