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Neural representation of central executive-An Fmri study-

中央执行系统的神经表征——一项 Fmri 研究——

基本信息

批准号：
16203037
负责人：
OSAKA Naoyuki
金额：
$ 26.79万
依托单位：
KYOTO UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16203037/
关键词：
Working Memory Central Executive Prefrontal Cortex ACC Attention Reading Span 上部頭頂小葉内側前頭前野 RST ワーキングメモリー

项目摘要

Using functional magnetic resonance imaging (fMRI) and transcranial magnetic stimulation (TMS), brain's prefrontal cortex was investigated in terms of working memory functions in human. Individual differences in working memory capacity were measured by use of reading span test both for young (graduate and undergraduate student) and elderly people (over 65). Results showed that the central executive that plays critical attentional mechanism for efficient working memory control incorporated in the dorsolateral prefrontal cortex (DLPFC), ventrolateral prefrontal cortex (VLPFC), medial prefrontal cortex (MPFC) and superior parietal lobule (SPL). These areas, working together, are highly possible to contribute efficient and adaptive processing of high-level cognition and behavior. Thus the area could be called as the central executive complex system. Specifically, we found anterior cingulated cortex (ACC) in the medial prefrontal cortex plays an important role in the processing and maintenance of ongoing verbal/spatial information. Using reading span test, we found high functional connectivity for high working memory subjects between DLPFC and ACC. This suggests that high performer's efficient working memory processing is likely based on efficient control of DLPFC-ACC executive complex.

应用功能磁共振成像（fMRI）和经颅磁刺激（TMS）技术，研究了人前额叶皮层的工作记忆功能。采用阅读广度测验对青年人（研究生和本科生）和老年人（65岁以上）的工作记忆容量进行了个体差异的测量。结果表明，对有效的工作记忆控制起关键作用的中央执行参与了背外侧前额叶皮层（DLPFC）、腹外侧前额叶皮层（VLPFC）、内侧前额叶皮层（MPFC）和上级顶叶小叶（SPL）。这些区域一起工作，很可能有助于高层次认知和行为的有效和适应性处理。因此，该区域可称为中央执行复合系统。具体来说，我们发现内侧前额叶皮层的前扣带皮层（ACC）在持续的言语/空间信息的加工和维持中起着重要的作用。通过阅读广度测验，我们发现高水平工作记忆被试的DLPFC和ACC之间存在高度的功能连接，这表明高水平工作记忆被试的高效工作记忆加工可能是基于对DLPFC-ACC执行复合体的有效控制。