Mechanism of molecular basis for "Tailor-made and measurable physical exercise program "and the educational application, evaluated from stress protein (molecular chaperone).
Mechanism of molecular basis for "Tailor-made and measurable physical exercise program "and the educational application, evaluated from stress protein (molecular chaperone).
批准号:
17200039
负责人:
ATOMI Yoriko
金额:
$30.95万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2006
中文摘要
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英文摘要
The principle of "tailor-made and measurable physical exercise program' has been studied from dual protein fiber structures of the cytoskeleton and extracellular matrix (ECM), and their molecular chaperone (stress proteins) for main tissues creating exercise, muscles and joints, and their constituting cells. Important results are as follows; 1) The C-terminal located crytallin domain in B-crystallin (B) works as chaperone against tubulin aggregation. 2) As GFP-1 B in beating cultured heart cells shows striation, it must function as chaperone for structural proteins. 3) The N terminal region of OB plays to decrease depolymerization of MAP-microtubule. 4) Disuse muscle atrophy induces the decrease of specific collagen chaperone HSP47 in ER. Similar results were obtained in cultured myoblasts. Possible new gravity-response element in the regulatory domain of HSP47 gene will be identified. 5) The increased temperature of 2 11 of cultured muscle cells facilitates muscle differentiation and increase slow myosin expression. 6) Mild running exercise induces type III collagen, hyaluronic acid synthase in rat knee joint, meaning existence of "good exercise" to contribute to change toward younger cellular environment in our body. 7) Phosphorylated CB/HSP27 and ubiquitinated proteins in human sedentary elderly skeletal muscle increase, suggesting lowered protein degradation. 8) HSP70 was coprecipitated with a key enzyme of glucocorticoid synthesis: StAR in adrenal gland, the peripheral tissue of HPA axis. Stress protein is available for a marker of good and measurable, adaptation connecting both cells and body. 1 earning program of cellular changes by exercise was introduced into compulsory curriculum of physical education and health science for 1st year students the University of Tokyo from 2006. Results of questionnaires by students indicated a contribution of the effectiveness of such a mixed education of knowledge learning and experiment using own body.
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HSP47, a collagen-specific stress protein, changes with gravitational conditions in skeletal muscle
HSP47 是一种胶原蛋白特异性应激蛋白,会随着骨骼肌中的重力条件而变化
DOI:
--
发表时间:
2005
期刊:
影响因子:
--
作者:
[Asami Oguro, Yoriko Atomi]
通讯作者:
Yoriko Atomi
'Cell Theory Revised'から考える筋細胞の動的特性と構造連関の意味.シンポジウム「ダイナミック適応重力場」でうまれた生物原理を探る
从“细胞理论修订”的角度探讨肌肉细胞的动态特性和结构关系的意义,源于“动态自适应重力场”研讨会。
DOI:
--
发表时间:
2005
期刊:
影响因子:
--
作者:
[Atomi, Y., 跡見順子]
通讯作者:
跡見順子
DOI:
--
发表时间:
2005
期刊:
影响因子:
--
作者:
[Oguro, A., Sakurai, T., Fujita Y., Kubota H., Nagata K., Y. Atomi.]
通讯作者:
Y. Atomi.
Open campus : Sports and physical exercise in the University of Tokyo-body and mind of the cell, which physical exercise educates. Experiment : Observation of heart cell and self- an analysis of beating heart of self body during exercise. Stretch and Tai-
开放校园:东京大学的体育和体育锻炼——体育锻炼教育的身心细胞。
DOI:
--
发表时间:
2005
期刊:
影响因子:
--
作者:
[Atomi, Y.]
通讯作者:
Y.
To do science through moving
通过运动做科学
DOI:
--
发表时间:
2005
期刊:
影响因子:
--
作者:
[Atomi, Y.]
通讯作者:
Y.
共 161 条
Body-brain holistic biology on the gravity health science platform
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批准号:23650416
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
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财政年份:2011
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负责人:ATOMI Yoriko
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依托单位:
Effect of endurance exercise at lactate threshold level on mental and physical health
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Evaluation of physical exercise on the basis of stress protein (3) - Relation to mechanical and physical stress induced in our body and the effect of constitutive expression and over expression -
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批准号:12308001
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资助金额:$28.5万
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财政年份:2000
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依托单位:
Evaluation of Physical Exercise from Stress Protein (2)-Evallluation of Hypoactivity and Training Effect-
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$7.42万
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财政年份:1998
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负责人:ATOMI Yoriko
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依托单位:
The evaluation of physical exercise by stress protein.
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批准号:08458016
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$4.93万
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财政年份:1996
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负责人:ATOMI Yoriko
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依托单位:
The establishment of research model on constitution and exercise experiment-review of animal study model-
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批准号:07558138
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$0.83万
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财政年份:1995
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负责人:ATOMI Yoriko
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依托单位:
Stress protein and fiber type
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批准号:04454587
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.03万
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财政年份:1992
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负责人:ATOMI Yoriko
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依托单位:
Mechanism of Antigravity Muscle Atrophy
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批准号:01480132
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$0.96万
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财政年份:1989
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负责人:ATOMI Yoriko
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依托单位:
海外基金