Treatment of central and/or peripheral nerve injury using artificial matrix and/or differentiated bone marrow stromal cell

使用人工基质和/或分化的骨髓基质细胞治疗中枢和/或周围神经损伤

• 批准号: 17209056
• 负责人: SUZUKI Yoshihisa
• 金额: $ 31.95万
• 依托单位: Tazuke Kofukai Medical Research Institute (2006-2007)Kyoto University (2005)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17209056/
• 关键词: central nerve; peripheral nerve; regeneration; bone marrow; spinal cord; 再生医療; マトリクス; ペプチド; トランスレーショナル; 移植・再生医療; 神経科学

(1) The neurosphere cells were injected into the cerebrospinal fluid through the 4th ventricle of young rats that had been given a contusion injury at T8-9 of the spinal cord. The grafted stem cells survived well in the host spinal cord and were cell integrated into the host tissue, extending their processes around nerve fibers in the same manner as astrocyte.(2) The spinal cord of the young rat was injured by contusion at the level of T8-9, and the BMSCs from the bone marrow were infused into the cerebrospinal fluid through the 4th ventricle. BMSCs attached to the spinal surface and a few invaded the lesion. The recovery of locomotion was better, and the cavity volume was smaller in the rat with implantation than in the control rats.(3) Based on these studies, we aimed at the clinical application, and actually planned a clinical trial of spinal cord injury treatment by transplanting patient's autologous BMSCs into CSF. We have experienced one case. Motor and sensory scores gradually but apparently improved at 1 and 3 months compared with the scores before the transplantation.

(1)将神经球细胞注入T8-9脊髓挫伤幼鼠的脑脊液中。移植的干细胞在宿主脊髓中存活良好，并整合到宿主组织中，以星形胶质细胞的方式在神经纤维周围延伸。(2)幼年大鼠T8-9水平的脊髓挫伤，骨髓中的BMSCs通过第四脑室注入脑脊液中。骨髓间充质干细胞附着于脊髓表面，少数细胞侵袭病变。植入组大鼠运动功能恢复明显好于对照组，空洞体积小于对照组。(3)在上述研究的基础上，我们着眼于临床应用，实际规划了一项将患者自体骨髓间充质干细胞植入脑脊液治疗脊髓损伤的临床试验。我们已经经历了一个案例。术后1个月和3个月运动和感觉评分逐渐提高，但与移植前相比有明显改善。

项目成果

脳脊髄液経由細胞移植法による脊髄損傷治療-特に骨髄間質細胞移植による脊髄損傷治療

使用脑脊液细胞移植治疗脊髓损伤 - 特别是使用骨髓基质细胞移植治疗脊髓损伤

• 发表时间: 2005
• 期刊: 細胞 37
• 作者: 太田正佳;鈴木義久;井出千束
• 通讯作者: 井出千束

再生医学的手法を用いた末梢神経再生

使用再生医学技术进行周围神经再生

• 发表时间: 2005
• 期刊: PAPERS 3
• 作者: 太田正佳;鈴木義久
• 通讯作者: 鈴木義久

Transplantation of artificial materials for nerve regeneration, Encyclopedic Reference in Neuroscience (Eds. MD Binder, N Hirokawa, U Windhorst)

用于神经再生的人造材料移植，神经科学百科全书参考（编辑：MD Binder、N Hirokawa、U Windhorst）

• 期刊: Springer-Verlag. (in press)
• 作者: 太田正佳;鈴木義久;Ohta M.,Suzuki Y. and Ide C.;Ohta,M.,Suzuki,Y.,Ide,C.
• 通讯作者: Ohta,M.,Suzuki,Y.,Ide,C.

The biodgeradability of poly(Pro-Hyp-Gly) synthetic polypeptide and the promotion of a dermal wound epithelialization using a poly(Pro-Hyp-Gly) sponge

聚（Pro-Hyp-Gly）合成多肽的生物降解性以及使用聚（Pro-Hyp-Gly）海绵促进真皮伤口上皮化

• 发表时间: 2008
• 期刊: Journal of Biomedical Materials Research. Part A. 85A
• 作者: Tanihara;M.;Kajiwara;K.;Szuki;Y.;Kamitakahara;M.;Ogata;S.
• 通讯作者: S.

Temporal skin grafts following straight incision for syndactyly correction

直切口后颞部皮肤移植以矫正并指

• 发表时间: 2005
• 期刊: Annals of Plastic Surgery 55
• 作者: Saito;A.;Suzuki;Y.;Kitamura;M.;Ogata;S.;Yoshihara;Y.;Masuda;S.;Ohtsuki;C.;Tanihara;M.;Saito,A.,Suzuki,Y.,Ogata,S.,Ohtsuki,C.,Tanihara,M.;Sawabe,K.,Suzuki,Y.,Suzuki,S.
• 通讯作者: Sawabe,K.,Suzuki,Y.,Suzuki,S.