Comprehensive basic study on optimum flow condition of total artificial heart from the view point of microcirculation

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It was succeeded to develop the following research tools to clarify the influences of flow dynamic states of total artificial heart such as pulsatile flow, continuous flow, etc. on microcirculation of the living body ; 1) Undulation pump total artificial heart that was enough compact to be implanted into the chest cavity of a goat weighing 40Kg and could generate any style of flow waveform, was developed. 2) A microcirculation probe that could be implanted into the body and observe continuously the microcirculation in the peripheral system without a microscope was developed. 3) These systems were implanted into goats chronically. The longest implantation period was 153 days and the difference between pulsatile and continuous flow on the living body including microcirculation was analysed during this period.