Comprehensive basic study on optimum flow condition of total artificial heart from the view point of microcirculation

从微循环角度探讨全人工心脏最佳血流条件的综合基础研究

• 批准号: 18200029
• 负责人: IMACHI Kou
• 金额: $ 31.28万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18200029/
• 关键词: 微小循環; 人工心臓; 拍動流; 連続流; 波動型完全人工心臓; 微小循環観察プローブ; 血管新生; Scaffold

It was succeeded to develop the following research tools to clarify the influences of flow dynamic states of total artificial heart such as pulsatile flow, continuous flow, etc. on microcirculation of the living body ; 1) Undulation pump total artificial heart that was enough compact to be implanted into the chest cavity of a goat weighing 40Kg and could generate any style of flow waveform, was developed. 2) A microcirculation probe that could be implanted into the body and observe continuously the microcirculation in the peripheral system without a microscope was developed. 3) These systems were implanted into goats chronically. The longest implantation period was 153 days and the difference between pulsatile and continuous flow on the living body including microcirculation was analysed during this period.

为了阐明全人工心脏脉动流、连续流等流动动态状态对活体微循环的影响，成功开发了以下研究工具；1)研制出体积紧凑，可植入体重40Kg的山羊胸腔内的脉动泵全人工心脏，该心脏可产生任意类型的血流波形。2)研制了一种可植入体内，无需显微镜即可连续观察外周系统微循环的微循环探针。这些系统被长期植入山羊体内。最长植入时间为153天，并分析此期间活体脉动与连续血流（包括微循环）的差异。

项目成果

テーブルマッピング法を用いた波動型人工心臓の流量推定

基于表格映射法的波型人工心脏流量估计

• 发表时间: 2008
• 作者: Aramaki M;Hokuto I;Matsumoto T;Ishimoto H;Inoue M;Kimura T;Oikawa Y;Ikeda K;Yoshimura Y;Takahashi T;Kosaki K;Akira Tsujimura;井上雄介
• 通讯作者: 井上雄介

Computational fluid dynamics analysis of undulation pump

波动泵的计算流体动力学分析

• 发表时间: 2007
• 作者: Nakagawa;K;Ozawa;N;Takamatsu;K;Takahashi;Y;Irahara;M;Yoshimura;Y;Saito;H;Isoyama T
• 通讯作者: Isoyama T

人工弁を内蔵しない波動型完全人工心臓-拍動流駆動および両心連続流駆動における1/R 制御の慢性動物実験-

无内置人工瓣膜的波形式完整人工心脏-脉动流驱动和双心连续流驱动中1/R控制的慢性动物实验-

• 发表时间: 2007
• 作者: 阿部裕輔

血管新生観察のための体内埋込型CCDプローブの開発

开发用于观察血管生成的植入式 CCD 探针

• 发表时间: 2006
• 作者: Tsuji;H;Ikegami;Y;Miyoshi;S;Hida;N;Nishiyama;N;Togashi;I;Nakamizo;H;Asada;H;Uyama;T;Tanaka;M;Segawa;K;Inoue;J;Ogawa;S;Yoshimura;Y;Umezawa;A;杉野礼佳
• 通讯作者: 杉野礼佳

特許「血液用らせん流ポンプ」

专利：“血液螺旋流泵”

• 发表时间: 2007