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Joint Study for Clinical Application of Artificial Heart

人工心脏临床应用联合研究

基本信息

批准号：
06044067
负责人：
IMACHI Kou
金额：
$ 6.78万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1994
资助国家：
日本
起止时间：
1994 至 1995
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-06044067/
关键词：
Artificial heart Clinical application of artificial heart Blood pump Blood compatibility Control method of artificial heart Sensor

项目摘要

The great numbers of residual problems in artificial heart disturb its longterm clinical use. We, University of Tokyo and Wien University, had cooperated for the past 2 years about the basic problems in the artificial heart. The objectives of our cooperation in this project is to solve many problems disturbing the longterm clinical application of total artificial heart and cardiac assist. In this final year, the following results have been accomplished by our cooperation.1. The anatomical fittness, blood compatibility, material and its molding method of undulation pumped TAH and flow transformed pulsatile TAH that were developing in University Tokyo were discussed.2. As for MAD (Modified Assist Device) that was developing in University Tokyo and could be approached transcutaneously, we exchanged opinions from the view point of clinical use.3. We discussed about 1/R control method that was a quite new control method of TAH and could survive a TAH goat more than 500 days in University of … More Tokyo. Especially, they interested in the mechanism of the method, its possibility to use clinically and its application to implantable centrifugal pump that was developing in Wien University.4. Concernig to the blood compatibility of the materials used in the artificial heart, the data used in the longest survival goat was discussed especially about the cause of carcification generated on the Jellyfish valves.5. We discussed about how to evaluate hemody namics and microcirculation during the artificial heart pumping. Implantable apparatus to observe the microcirculation using CCD and cathecolamine sensor that were developed in University of Tokyo were also discussed.6. Blood compatibility, performance and control method of implantable centrifugal blood pump that have been developing in Wien University were discussed.7. As a bridge patient were in the University hospital at that time, we could get many informations of performance, blood compatibility, safety and reliability of the clinical use of Novacor implantable left ventricular assist device as the bridge to the heart transplntation.These results were reported at 22nd Annual Meeting of European Society for Artificial Organs, 10th Biannual Conference of International Society for Artificial Organs and other domestic conferences. Less

人工心脏存在大量残留问题，影响其临床的长期应用。我们东京大学和维也纳大学在过去的两年里就人工心脏的基本问题进行了合作。我们合作这个项目的目的是为了解决困扰全人工心脏和心脏辅助长期临床应用的诸多问题。在过去的一年里，我们的合作取得了以下成果：讨论了日本东京大学正在研制的脉动泵和脉动泵的解剖适应性、血液相容性、材料及其成型方法。对于东京大学正在研发的可经皮接触的MAD (Modified Assist Device)，我们从临床使用的角度交换了意见。我们讨论了1/R控制方法，这是一种非常新的控制方法，可以在东京…more大学使TAH山羊存活500天以上。他们特别对该方法的机理、临床应用的可能性以及在维也纳大学正在开发的植入式离心泵中的应用感兴趣。关于人工心脏材料的血液相容性，本文讨论了存活时间最长的山羊所使用的资料，特别是海水母瓣膜发生钙化的原因。讨论了人工心脏泵送过程中血液动力学和微循环的评价方法。并讨论了日本东京大学研制的CCD和儿茶酚胺传感器植入式微循环观察装置。介绍了维也纳大学研制的植入式离心血泵的血液相容性、性能及控制方法。作为当时大学医院的桥梁患者，我们可以获得很多关于Novacor植入式左心室辅助装置作为心脏移植桥梁临床使用的性能、血液相容性、安全性和可靠性等信息。研究结果已在第22届欧洲人工器官学会年会、第10届国际人工器官学会双年会等国内会议上发表。少