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Comprehensive research concerned with the influence of flow state of artificial heart on living body by observation of microcirculation

通过观察微循环来综合研究人工心脏的流动状态对生物体的影响

基本信息

批准号：
14104027
负责人：
IMACHI Kou
金额：
$ 65.4万
依托单位：
Tohoku University (2004-2005)The University of Tokyo (2002-2003)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (S)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2005
项目状态：
已结题

项目摘要

Although many types of continuous flow ventricular assist devices have become to use clinically as the bridge to heart transplantation, no body knows whether the pulsatility of blood flow is essential for living body or not. We have succeeded the basic development to solve the problem ; undulation pump AH(UPAH) and CCD probe. UPAH can change instantaneously its flow patterns by computer control of motor rotational speed. CCD probe is implantable micro-camera to observe microcirculation chronically.The objective of this study is to clarify the necessity of pulsatility for the living body by developing more completely UPTAH and CCD probe. The following outcome has been gotten in these 4 years :1)UPAHBlood compatibility, durability and size ＆ weight were improved great deal. The goat implanted UPAH survived maximally 4 months without anticoagulant. The software to control blood waveform has also been developed.2)CCD probeHigh magnification, focus adjust system and miniaturization were the objective to be developed. A micro-lens, 2 mm in diameter and 2 mm long was developed. The lens was installed into a CCD camera having 8 mm in diameter and 60 mm long. Total magnification on 14 inch TV screen was 650 times, that was enough to observe the erythrocyte flow in a capillary vessel. It could be implanted in an animal without difficulty. Residual problem is focus adjusting system.3)Microcirculation under UPAHThe blood flow pattern was changed instantaneously from pulsatile to continuous when UPAH goat recover from surgical stress. The microcirculation was observed at bulbar conjunctiva during experiment. Following phenomena were observed until now : (1)Capillary density that is the ratio of the flowing capillaries to total capillary number, was decreased 30%. (2)The erythrocyte flow rate in the capillary was decreased 75 and some of them did not recover after the flow pattern returned to pulsatile.

虽然许多类型的连续流动心室辅助装置已成为临床上使用的桥梁，心脏移植，没有人知道是否脉动的血流是必不可少的活体。我们已经成功地解决了这个问题的基本发展：波动泵AH（UPAH）和CCD探头。通过计算机控制电机转速，UPAH可以瞬间改变其流态。CCD探头是一种可长期观察微循环的植入式微型摄像机，本研究的目的是通过研制更完整的UPTAH和CCD探头，阐明活体微循环搏动的必要性。4年来取得了以下成果：1）UPAH的血液相容性、耐久性和体积重量都有了很大的提高。山羊UPAH植入后无抗凝剂最长存活4个月。2）CCD探头的高倍率、调焦系统和小型化是发展的目标。研制了直径2 mm、长2 mm的微透镜。将该透镜安装在直径为8 mm、长为60 mm的CCD照相机中。在14英寸电视屏幕上，总放大倍数为650倍，足以观察毛细血管中的红细胞流动。它可以毫无困难地植入动物体内。3）UPAH下的微循环UPAH山羊术后恢复时，血流模式由搏动性瞬间变为连续性。实验过程中观察球结膜微循环。观察到以下现象：（1）毛细管密度，即流动毛细管数与总毛细管数的比值，降低了30%。（2）红细胞在毛细血管中的流速降低75%，部分红细胞在恢复搏动后仍不能恢复。

项目成果

期刊论文数量（49）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Microcirculation of the Bulbar Conjunctiva in the Goat Implanted with a Total Artificial Heart: Effects of Pulsatile and Nonpulsatile Flow

DOI：
10.1097/01.mat.0000129320.57362.db
发表时间：
2004-07
期刊：
ASAIO Journal
影响因子：
4.2
作者：
A. Baba;P. Dobsak;I. Saito;T. Isoyama;K. Takiura;Y. Abe;T. Chinzei;J. Vašků;K. Imachi
通讯作者：
A. Baba;P. Dobsak;I. Saito;T. Isoyama;K. Takiura;Y. Abe;T. Chinzei;J. Vašků;K. Imachi

Y.Abe, K.Imachi, et al.: "Third model of the undulation pump total artificial heart"ASAIO Journal. 49(1). 325-332 (2003)

Y.Abe、K.Imachi等人：“波动泵全人工心脏的第三种模型”ASAIO杂志。