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Joint Study to Develop a Long-term Use Artificial Heart

联合研究开发长期使用的人造心脏

基本信息

批准号：
08044252
负责人：
IMACHI Kou
金额：
$ 4.35万
依托单位：
University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for international Scientific Research
财政年份：
1996
资助国家：
日本
起止时间：
1996 至无数据
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08044252/
关键词：
Artificial heart Total artificial heart Assist heart Centrifugal pump Vibrating pump Blood compatibility Antithrombogenic material Control method

项目摘要

As the consequence of the success in short-term clinical use of artificial heart, longer term application of artificial heart for the bridge to heart transplantationis strongly required. This joint study was designed to perform cooperative research of the following items among University of Tokyo, Tohoku University, National Cardiovascular Center and Wien University under their longterm experiences to develop the artificial heart and biomaterials : 1) To clarify the problems during clinical use of artificial heart. 2) To develop a safer and more reliable artificial heart system that can be used clinically for longterm. The following outoutcome have been obtained in this year.1 A cooperative member in Wien University was invited to University of Tokyo to discussed above mentioned items.2 Seven Japanese members visited to Wien University to discuss about the clinical use of artificial heart.3 The following discussions have been done through these interchanges : (1) the peformance, anatom … More ical fitting and blood compatibility of total artificial heart and assist circulation that are developing in University of Tokyo, (2) the cause of calcification generated on the jellyfish valve and measures for it, (3) appropriateness of 1/R controlmethod of total artificial heart that have been performing at University of Tokyo and its possibility to apply clinically, (4) the relationship between frequency and blood distribution during the left heart bypass with vibrating flow pump developed by Tohoku University and appropriate ness of hemodynamics evaluation with chaos theory, (5) the improvement of the performance and blood compatibility of the centrifugal pump developed by Wien University, (6) the hemodynamic data, blood chemical data, control method, anticoagulant therapy and complications of clinical patients implanted a ventricular assist device for bridge to heart transplantation, (7) improvement of blood compatibility og an artificial heart by the materials and methods developed at National Cardiovascular Center.4 These reurlts were reported at 42nd Annual Meetings of American Society for Artificial Internal Organs, 6th International Symposium on Artificial Heart and Assist Devices, 23rd Congress of European Society for Artificial Organs and 34th Annual Meetings of Japanese Society for Artificial Organs. Less

随着人工心脏短期临床应用的成功，人工心脏作为心脏移植桥的长期应用是非常必要的。本次联合研究旨在由东京大学、东北大学、国立心血管中心和维也纳大学根据其长期开发人工心脏和生物材料的经验进行合作研究：1)澄清人工心脏临床应用中存在的问题。2)开发一种更安全、更可靠、可长期用于临床的人工心脏系统。今年取得了以下成果：1.维也纳大学的一名合作成员应邀到东京大学讨论上述项目2.7名日本成员访问了文大，讨论了人工心脏的临床应用。3.通过这些交流，进行了以下讨论：(1)性能，ANATOM…(2)水母瓣膜钙化的原因及措施；(3)东京大学已有的全人工心脏1/R控制方法的适宜性及其临床应用的可能性；(4)东北大学研制的振动流量泵在左心转流过程中频率与血液分布的关系及用混沌理论评价血液动力学的适宜性；(5)维恩大学研制的离心泵性能和血液相容性的改进。(6)临床患者植入心脏搭桥辅助装置的血流动力学数据、血液化学数据、控制方法、抗凝治疗和并发症；(7)利用国家心血管中心研制的材料和方法改善人工心脏的血液相容性。4.第42届美国人工内脏学会年会、第6届国际人工心脏和辅助装置研讨会、第23届欧洲人工器官学会大会和第34届日本人工器官学会年会。较少