The basic study to develop an artificial heart of the next generation type

开发下一代人工心脏的基础研究

• 批准号: 04404054
• 负责人: IMACHI Kou
• 金额: $ 19.84万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (A)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1994
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04404054/
• 关键词: Artificial heart; Distributed artificial heart; Control of artificial heart; Blood pump; Surface plasmon microscope; Catecholamine sensor; Microcirculation; Jellyfish valve; 模擬循環装置; 腎循環; 人工弁; ポリウレタン

Although the artificial heart is already useful for saving the post cardiotomy and bridge to heart transplantation patients, the artificial heart study is gradually coming to a standstill, because its fundamental concept is based on the ideas to mimic the natural heart. To breakthrough the deadlock, it would be important to propose a novel artificial heart which is free from the morphology of the natural heart and is superior to the natural heart in its function by changing our conception and to start the basic investigation.The following results were obtained through three years project.1 A distributed artificial heart was proposed as the next generation type, in which the left artificial heart is distributed to many organs and tissues, and was discussed about its significance and possibility.2 As for the miniaturization of artificial heart, (1) development a small size jellyfish valve with 4mm diameter, (2) development two types of artificial heart with new mechanisms and their miniaturization, (3) development of new type assist device to be approached percutaneously, (4) development of artificial muscle utilizing the micromachine technology, were studied.3 The following new measurement methods were developed. (1) Development of a surface plasmon microscope to detect the behavior of plasma protein absorbed on a material surface. (2) Development a blood catecholamine sensor for artificial heart control. (3) Development a new implantable probe to observe the real time microcirculation chronically at the waked condition.4 A new control method of artificial heart (1/R control method) was developed, in which the cardiac output was controled by the animal herself by changing her total peripheral resistance. A goat survived for 360 days and another goat

虽然人工心脏已经在挽救心脏手术后的生命和心脏移植患者的桥梁上发挥了重要作用，但由于其基本概念是模仿天然心脏，人工心脏的研究正逐渐陷入停滞。为了突破这一僵局，我们必须改变观念，提出一种新的、不依赖于自然心脏形态的、在功能上优于自然心脏的上级人工心脏，并开展基础研究。经过三年的研究，我们取得了以下成果：1提出了分布式人工心脏作为下一代人工心脏，其中左侧人工心脏分布于多个器官和组织，并讨论了其意义和可能性。2在人工心脏小型化方面，（1）研制直径为4 mm的小型水母瓣，（2）开发两种新机构的人工心脏及其小型化，（3）开发新型辅助装置，（4）开发利用微机械技术的人工肌肉，3.开发了以下新的测量方法。(1)表面电浆子显微镜侦测血浆蛋白质吸附于材料表面之行为。(2)用于人工心脏控制的血液儿茶酚胺感测器之研制。(3)4.提出了一种新的人工心脏控制方法（1/R控制法），即通过改变动物的外周总阻力来控制心输出量。一只山羊存活了360天，另一只山羊

项目成果

Yusuke Abe: "Can Total Artificial Heart Animals Control Their TAH by Themselves? One Year Survival of a TAH Goat Using a New Automatic Control Method(1/R Control)" ASAIO Journal. 40. 506-509 (1994)

Yusuke Abe：“全人工心脏动物能否自行控制 TAH？使用新的自动控制方法（1/R 控制）使 TAH 山羊存活一年”ASAIO 杂志。

Kou Imachi: "A New Apparatus for Chronic Observation of the Microcirculation In Situ to Evaluate Artificial Organ Performance" ASAIO Journal. 40. 757-761 (1994)

Kou Imachi：“一种用于长期观察原位微循环以评估人工器官性能的新装置”ASAIO 杂志。

磯山隆: "流れ変換型拍動流完全人工心臓システムの開発-血液混合の少ない連続流ポンプの開発-" 人工臓器. 23. 60-64 (1994)

Takashi Isoyama：“流量转换型脉动流完整人工心脏系统的开发 - 血液混合较少的连续流泵的开发 -”Artificial Organs（人工器官）。

鎮西恒雄: "抗血栓性材料表面における電界のタンパク吸着に及ぼす影響" 医用電子と生体工学. 32. 169- (1994)

Tsuneo Chinzei：“电场对抗血栓材料表面蛋白质吸附的影响”《医疗电子与生物工程》32. 169- (1994)。

Yusuke Abe, et al.: "Reciprocal of the peripheral vascular resistance (1/R) control method for the total artificial heart" Heart Replacement : Artificial Heart 4, Springer-Verlag Tokyo. 349-351 (1993)

Yusuke Abe 等人：“全人工心脏的外周血管阻力 (1/R) 控制方法的倒数”《心脏置换：人工心脏 4》，Springer-Verlag Tokyo。