Joint Study to Solve the Basic Problems in Artificial Heart

共同研究解决人工心脏的基本问题

• 批准号: 04044053
• 负责人: IMACHI Kou
• 金额: $ 8.51万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04044053/
• 关键词: Artificial heart; Blood pump; Circulatory control; Heart transplantation; Antithrombogenicity; Centrifugal blood pump; Animal experiment; Artificial valve; 血行動態

The aim of this international joint study is to promote the artificial heart (AH) research and its clinical application at the points of control, pathophysiology and blood compatibility. During the past two years, both research staffs visited each others once a year and stayed for one week to perform a experiment and exchange the information through the effective discussion. As the consequence of these joint study, the following excellent results has obtained ;1 Concerning the clinical application of AH as the bridge to heart transplantation, to which they had several case experience, we could get many information concerning the anatomical fitting of a blood pump, surgical operation techniques and post operative management.2 The discussion about the AH animal experiments, the animal data got from the calf by Vienna group, and from the goats by our group were exchanged to clarity the data difference by the speceis and age.3 They joined our total AH animal experiment using a goat and discussed about what is a bottle neck to obtain more longer survival.4 Concerning the AH automatic control method, they had a strong interest to our new automatic control method named as 1/R control method, in which the AH goat herself can control her cardiac output at optimum value by changing her total peripheral resistance. And we discussed about the mechanism and meaning of this control method taking a lot of time.5 We also discussed about two new types of AH produced by our group under the quite new ideas.6 They tested the blood compatibility of our jellyfish valve with a acceleration test method developed by Vienna group.7 To improve the antithrombogenicity of a centrifugal blood pump developed by Vienna group, we arranged to get a good blood compatible material, MPC polymer developed by Nakabayashi and Isihara.As mention above, both group had a great advantages in the AH research through 2 year's joint study.

本国际联合研究的目的是促进人工心脏（AH）的研究及其在控制、病理生理和血液相容性方面的临床应用。在过去的两年中，双方研究人员每年互相拜访一次，并停留一周进行实验，通过有效的讨论交流信息。这些共同研究的结果，取得了以下优秀成果：1关于AH作为心脏移植的桥梁的临床应用，他们有几个案例的经验，我们可以得到很多关于血泵的解剖安装，外科手术技术和术后处理的信息2 .关于AH动物实验的讨论，将维也纳组犊牛实验数据与我组山羊实验数据进行了交换，以明确不同品种和年龄的数据差异他们加入了我们用山羊做的全AH动物实验，并讨论了获得更长的生存时间的瓶颈是什么关于AH的自动控制方法，他们对我们新的自动控制方法非常感兴趣，这种自动控制方法被称为1/R控制方法，即AH山羊自己通过改变其总外周电阻来控制其心输出量在最佳值。并花了大量的时间讨论了这种控制方法的机理和意义5 .我们还讨论了我们组在全新理念下生产的两种新型AH他们用维也纳集团开发的加速测试方法测试了我们的水母瓣膜的血液相容性为了提高维也纳集团开发的离心血泵的抗血栓性，我们安排了一种良好的血液相容性材料，由Nakabayashi和Isihara开发的MPC聚合物。如前所述，通过2年的联合研究，两组在AH研究上有很大的优势。

项目成果

Y.Abe: "Artificial Heart-The Development of Biomation in the 21st Century (Y.Sezai Ed)" Harcourt Brace Jovanovich Japan Inc.,Tokyo, 386 (1992)

Y.Abe：“人工心脏 - 21 世纪生物技术的发展（Y.Sezai Ed）” Harcourt Brace Jovanovich Japan Inc.，东京，386 (1992)

Kou Imachi: "Fabrication of a jellyfish valve for use in an artificial heart" ASAIO Journal. 38(3). M237-M242 (1992)

Kou Imachi：“用于人造心脏的水母瓣膜的制造”ASAIO 杂志。

Yusuke Abe: "Reciprocal of the peripheral vascular resistance(1/R)control method for the total artificial heart" Heart Replacement:Artificial Heart 4,Springer-Verlag Tokyo. 349-351 (1993)

Yusuke Abe：“全人工心脏的外周血管阻力（1/R）控制方法的倒数”《心脏置换：人工心脏 4》，东京施普林格出版社。

Takashi Isoyama: "Development of a pulsatile total artificial heart using a single continuous flow pump:development of the third model" Heart Replacement:Artificial Heart 4,Springer-Verlag Tokyo. 287-290 (1993)

Takashi Isoyama：“使用单个连续流泵开发脉动全人工心脏：第三种模型的开发”《心脏置换：人工心脏 4》，东京施普林格出版社。

K.IMACHI: "Fabrication of a jellyfish valve for use in an artificial heart" ASAIO Journal. 38(3). 237-242 (1992)

K.IMACHI：“用于人造心脏的水母瓣膜的制造”ASAIO 杂志。