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Basic and overall studies to solve the factors preventing the implantable total artificial heart

解决植入式人工心脏植入障碍因素的基础和总体研究

基本信息

批准号：
07407036
负责人：
IMACHI Kou
金额：
$ 21.5万
依托单位：
University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (A)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1997
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07407036/
关键词：
Artificial heart Totally implantable artificial heart Blood pump Artificial valve Control method Blood compatibility 人工弁

项目摘要

The following results have been obitained through 3 years research.1.Development of flow transformed pulsatile total artificial heart (FTPTAH)New structures of centrifugal blood pump were studies to reduce the blood mixture rate inside the pump and succeeded to reduce the blood mixture rate to 20 %. New mechanism of FTPTAH having the combination of undulation pump and 4 jellyfish valves was designed to reduce the size, to improve blood compatibility and to reduce the energy consumption.2.Development of undulationpump total artificial heart (UPTAH)UPTAH has been constructed with 2 undulation pumos and 2 brushless DC motor, that is the smallest mechanical TAH in the world. The basic studies concerning the fabrication method of the pump and the software to control UPTAH have been performed. As the results of these studies, UPTAH was implanted into the chest cavities of a goat weighing 41Kg and succeeded to survive her for about 11 days.3.The study of physiological control of TAHA new TAH control method, 1/R control method, in which the goat with TAH controls her own mechanical heart by changing her total peripheral resistance through biofeedback mechanism, was studied using pneumatically driven TAH and succeeded to survive a goat for 532 days without any pathophysiological state, which was the longest survivor under TAH in the world. The method is being studied to apply to UPTAH.4.New hypothesis concerning the mechanism of calcification on TAH polymer surfaceA new phenomena was found by analysing the calcified surface of a jellyfish valve drived over 300 days, that the calcification was concentrated at the point where received a repeated stretching force. A new hypothesis that could explain why the calcification was generated such a point, was proposed.5.Development of new senaorsA sensor to measure the blood chatecholamine level and a implantable probe to observe the microcirculation chronically, were developed.

经过3年的研究，取得了以下成果：1.流动转换型脉动全人工心脏的研制研究了离心式血泵的新结构，以降低泵内血液混合率，成功地将血液混合率降低到20%。2.波动泵型全人工心脏（UPTAH）的研制UPTAH由2个波动泵和2个无刷直流电机组成，是目前世界上最小的机械式全人工心脏。对泵的制造方法和控制UPTAH的软件进行了基础研究。将UPTAH植入41 Kg山羊胸腔内，成功存活11天。3. TAHA生理控制的研究新的TAH控制方法，1/R控制法，即TAH山羊通过生物反馈机制改变自身的总外周阻力来控制自身的机械心脏，结果1只山羊在TAH条件下存活532天，无任何病理生理状态，是目前世界上TAH条件下存活时间最长的山羊。4.关于TAH聚合物表面钙化机理的新假说通过对一个被驱300多天的水母瓣钙化表面的分析，发现了一个新的现象，即钙化集中在受到反复拉伸力的地方。提出了一个新的假说，可以解释为什么钙化是产生这样一个点。5.新传感器的开发一个传感器来测量血液中的儿茶酚胺水平和一个植入式探针，以长期观察微循环。