Crystallographic studies of macromolecular complexes in transcription and translation : RNA polymerases and the ribosome

点击翻译按钮获取中文摘要

To approach the structural basis of transcription and translation, we carried out structural studies on RNA polymerase and ribosome, which play a central role in transcription and translation, respectively. These include RNA polymerase bound with regulatory proteins and nucleic acids and small ribosomal subunit bound with regulatory proteins and RNA. We also established preparation method of eukaryotic proteins responsible for transcription or translation, and performed crystallography.