Regulation of intracellular vesicle transport by small GTPase cycles
Regulation of intracellular vesicle transport by small GTPase cycles
批准号:
20247011
负责人:
KATADA Toshiaki
金额:
$27.46万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010
中文摘要
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英文摘要
G proteins, which cycle between the two different GTP- and GDP-bound conformations (G cycles), play important roles as a "molecular switch" in many intracellular signaling pathways. In the Grant-in-Aid for Scientific Research (A), we investigated how G cycles are regulated dependent on their modes of actions in intracellular vesicle transport and found that novel G proteins containing unique biochemical properties and/or structures are involved in the regulation of endosome dynamics, such as lysosome biogenesis, endocytosis, and exocytosis.
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Distinct control of survival, and somatic and germline development during L1 diapause by the insulin/IGF signaling and AMPK pathway
通过胰岛素/IGF 信号和 AMPK 通路对 L1 滞育期间的生存、体细胞和种系发育进行明确控制
DOI:
--
发表时间:
2009
期刊:
影响因子:
--
作者:
[Fukuyama M, Sakuma K, Astumi Y, Shimomura H, Kasuga H, Rougvie A, Katada T]
通讯作者:
Katada T
細胞のシグナル伝達系に介在するGタンパク質:三量体Gタンパク質Giの発見からGタンパク質が果たす役割の拡大に向けて
G蛋白介导细胞信号转导系统:三聚体G蛋白Gi的发现扩大了G蛋白的作用
DOI:
--
发表时间:
2008
期刊:
影响因子:
--
作者:
[Nagasaki, K., Tomaru, Y., 藤本淳, 堅田利明]
通讯作者:
堅田利明
Characterization of RIN3 as a Guanine Nucleotide Exchange Factor for the Rab5 Subfamily GTPase Rab31
DOI:
10.1074/jbc.m110.172445
发表时间:
2011-07-08
期刊:
JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子:
4.8
作者:
[Kajiho, Hiroaki, Sakurai, Kyoko, Katada, Toshiaki]
通讯作者:
Katada, Toshiaki
DOI:
10.1038/cdd.2010.137
发表时间:
2011-04-01
期刊:
CELL DEATH AND DIFFERENTIATION
影响因子:
12.4
作者:
[Takahashi, S., Ebihara, A., Katada, T.]
通讯作者:
Katada, T.
Domain architecture of the atypical Arf-family GTPase Arll3b involved in cilia formation
参与纤毛形成的非典型 Arf 家族 GTPase Arll3b 的结构域
DOI:
--
发表时间:
2008
期刊:
Biochem.Biophys.Res.Commun. 373
影响因子:
--
作者:
[Hori Y., et al.]
通讯作者:
et al.
共 26 条
Identification of signaling pathways involved in fungal pathogenicity and search for novel targets for antifungal drugs
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批准号:20K06550
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.75万
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财政年份:2020
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负责人:KATADA Toshiaki
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依托单位:
Nutrient response mediated by a TRIM-NHL protein
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批准号:16K14693
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2016
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负责人:KATADA Toshiaki
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依托单位:
A novel signal transduction pathway which regulates the structure of P-body and the dynamics of ARE-mRNAs
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批准号:22659015
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$1.92万
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财政年份:2010
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负责人:KATADA Toshiaki
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依托单位:
Membrane-Transport Signaling Involving the GTPase Cycle of G proteins
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批准号:18207008
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.87万
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财政年份:2006
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负责人:KATADA Toshiaki
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依托单位:
Functional analysis of atypical G proteins involved in cell signaling network
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批准号:17079002
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$53.76万
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财政年份:2005
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负责人:KATADA Toshiaki
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依托单位:
New research initiatives in the study of G-protein signaling systems integrating cell communication network
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批准号:17079001
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$26.82万
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财政年份:2005
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负责人:KATADA Toshiaki
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依托单位:
The structure and function of a novel G protein family regulating eukaryotic mRNA dynamics
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批准号:13854025
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项目类别:Grant-in-Aid for Scientific Research (S)
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资助金额:$78.87万
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财政年份:2001
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负责人:KATADA Toshiaki
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依托单位:
G protein-dependent vectorial transportation of receptors, ion channels, and transporters
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批准号:12144202
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$32.77万
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财政年份:2000
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负责人:KATADA Toshiaki
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依托单位:
Physiological roles of cell surface ecto-enzymes
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批准号:11694249
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项目类别:Grant-in-Aid for Scientific Research (B).
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资助金额:$4.42万
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财政年份:1999
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负责人:KATADA Toshiaki
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依托单位:
Analysis of the functions of G protein βγ-Subunit and application to drug design
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批准号:10557220
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$8.19万
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财政年份:1998
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负责人:KATADA Toshiaki
-
依托单位:
Physiological functions of the cell surface antigen CD38
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批准号:09044268
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项目类别:Grant-in-Aid for international Scientific Research
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资助金额:$4.35万
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财政年份:1997
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负责人:KATADA Toshiaki
-
依托单位:
Physiological functions of a novel family of nucleotide-metabolizing enzymes
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批准号:09480160
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$7.94万
-
财政年份:1997
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负责人:KATADA Toshiaki
-
依托单位:
Analysis of New NAD-cleavage Enzymes Involved in Signal Transduction System
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批准号:08458193
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$4.35万
-
财政年份:1996
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负责人:KATADA Toshiaki
-
依托单位:
Assay of Cyclic ADP-ribose and Analysis of Its Target Molecules
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批准号:08557129
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$6.46万
-
财政年份:1996
-
负责人:KATADA Toshiaki
-
依托单位:
Regulation of adenylyl cyclase by GTP-binding Proteins
-
批准号:07044229
-
项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$4.67万
-
财政年份:1995
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负责人:KATADA Toshiaki
-
依托单位:
Development of Assay Methods for a Novel Intracellular Messenger, Cyclic ADP-ribose
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批准号:06557129
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$7.94万
-
财政年份:1994
-
负责人:KATADA Toshiaki
-
依托单位:
Analysis of NAD-cleavage Enzymes Involved in Signal Transduction System
-
批准号:06454651
-
项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$4.86万
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财政年份:1994
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负责人:KATADA Toshiaki
-
依托单位:
The roles of heterotrimeric GTP-binding proteins in signal transduction
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批准号:05271102
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项目类别:Grant-in-Aid for Scientific Research on Priority Areas
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资助金额:$124.93万
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财政年份:1993
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负责人:KATADA Toshiaki
-
依托单位:
Regulation of ion channels by GTP-binding Proteins
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批准号:05044153
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项目类别:Grant-in-Aid for international Scientific Research
-
资助金额:$4.16万
-
财政年份:1993
-
负责人:KATADA Toshiaki
-
依托单位:
Development of Drug Screening Methods Using the Activities of GTP-binding Proteins
-
批准号:04557107
-
项目类别:Grant-in-Aid for Developmental Scientific Research (B)
-
资助金额:$7.42万
-
财政年份:1992
-
负责人:KATADA Toshiaki
-
依托单位:
海外基金