课题基金 / 基金详情

Regulation of intracellular vesicle transport by small GTPase cycles

Regulation of intracellular vesicle transport by small GTPase cycles
小 GTP 酶循环调节细胞内囊泡运输
批准号:
20247011
负责人:
KATADA Toshiaki
金额:
$27.46万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2008
资助国家:
日本
项目状态:
已结题
起止时间:
2008 至 2010

项目摘要

项目成果

KATADA Toshiaki的其他基金

相似基金

相关文献

中文摘要
翻译
G蛋白在两种不同的GTP和gdp结合构象(G循环)之间循环,在许多细胞内信号通路中作为“分子开关”发挥重要作用。在科学研究资助(A)中,我们研究了G循环是如何根据其在细胞内囊泡运输中的作用模式进行调节的,并发现含有独特生化特性和/或结构的新型G蛋白参与了内体动力学的调节,如溶酶体的生物发生、内吞作用和胞吐作用。
英文摘要
G proteins, which cycle between the two different GTP- and GDP-bound conformations (G cycles), play important roles as a "molecular switch" in many intracellular signaling pathways. In the Grant-in-Aid for Scientific Research (A), we investigated how G cycles are regulated dependent on their modes of actions in intracellular vesicle transport and found that novel G proteins containing unique biochemical properties and/or structures are involved in the regulation of endosome dynamics, such as lysosome biogenesis, endocytosis, and exocytosis.
期刊论文(36)
专著(0)
科研奖励(0)
会议论文
Distinct control of survival, and somatic and germline development during L1 diapause by the insulin/IGF signaling and AMPK pathway
通过胰岛素/IGF 信号和 AMPK 通路对 L1 滞育期间的生存、体细胞和种系发育进行明确控制
DOI: --
发表时间: 2009
期刊:
影响因子: --
作者: [Fukuyama M, Sakuma K, Astumi Y, Shimomura H, Kasuga H, Rougvie A, Katada T]
通讯作者: Katada T
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Nagasaki, K., Tomaru, Y., 藤本淳, 堅田利明]
通讯作者: 堅田利明
DOI: 10.1074/jbc.m110.172445
发表时间: 2011-07-08
期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
影响因子: 4.8
作者: [Kajiho, Hiroaki, Sakurai, Kyoko, Katada, Toshiaki]
通讯作者: Katada, Toshiaki
DOI: 10.1038/cdd.2010.137
发表时间: 2011-04-01
期刊: CELL DEATH AND DIFFERENTIATION
影响因子: 12.4
作者: [Takahashi, S., Ebihara, A., Katada, T.]
通讯作者: Katada, T.
26
    Identification of signaling pathways involved in fungal pathogenicity and search for novel targets for antifungal drugs
    • 批准号:
      20K06550
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.75万
    • 财政年份:
      2020
    • 负责人:
      KATADA Toshiaki
    • 依托单位:
    Nutrient response mediated by a TRIM-NHL protein
    A novel signal transduction pathway which regulates the structure of P-body and the dynamics of ARE-mRNAs
    • 批准号:
      22659015
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $1.92万
    • 财政年份:
      2010
    • 负责人:
      KATADA Toshiaki
    • 依托单位:
    Membrane-Transport Signaling Involving the GTPase Cycle of G proteins
    • 批准号:
      18207008
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $31.87万
    • 财政年份:
      2006
    • 负责人:
      KATADA Toshiaki
    • 依托单位:
    海外基金