The liver damage preventive effect of the new composition fat emulsion preparations in the long-term intravenous nutrition of low-birth-weight infants after the intestinal operation

新组合物脂肪乳制剂对低出生体重儿肠道手术后长期静脉营养的预防肝损伤作用

• 批准号: 23890187
• 负责人: MITANI Yasuyuki
• 金额: $ 0.92万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890187/
• 关键词: 超低出生体重児; 脂肪乳剤; 肝障害; 超出生体重児

This research was done using the new composition preparations emulsified with PG (phosphatide compounded by epikuron200 and glycerol to phospholipase DM which is soy lecithin) which mixed MCT and LC in an equivalent amount of 1 to 1 as neutral fat 10%.Using four weeks of Wistar system age maleness rat, the self-sustaining intravenous dosage containing a new composition PG emulsification MCT/LCT agent was performed, and measurement of the neutral fat, phosphatide, HDL cholesterol, AST, ALT, direct, and indirect bilirubin value was performed. As a result, an impaired liver function was prominent at the medication speed of 1.2g/kg/hr and 1.8g/kg/hr, and it turned out that optimal speed is 0.6g/kg/hr.

本研究使用PG乳化的新组合物制剂进行将MCT和LC以1：1的当量混合作为中性脂肪10%的磷脂酶DM（由epikuron 200和甘油合成的磷脂）。使用4周龄Wistar系雄性大鼠，进行含有新组合物PG乳化MCT/LCT剂的自我维持静脉内剂量，并测量中性脂肪、磷脂、HDL胆固醇、AST、ALT、直接和间接胆红素值。结果，肝功能受损在1.2g/kg/hr和1.8g/kg/hr的给药速度下显著，结果证明最佳速度为0.6g/kg/hr。