The liver damage preventive effect of the new composition fat emulsion preparations in the long-term intravenous nutrition of low-birth-weight infants after the intestinal operation

新组合物脂肪乳制剂对低出生体重儿肠道手术后长期静脉营养的预防肝损伤作用

• 批准号: 23890187
• 负责人: MITANI Yasuyuki
• 金额: $ 0.92万
• 依托单位: Wakayama Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-23890187/
• 关键词: 超低出生体重児; 脂肪乳剤; 肝障害; 超出生体重児

This research was done using the new composition preparations emulsified with PG (phosphatide compounded by epikuron200 and glycerol to phospholipase DM which is soy lecithin) which mixed MCT and LC in an equivalent amount of 1 to 1 as neutral fat 10%.Using four weeks of Wistar system age maleness rat, the self-sustaining intravenous dosage containing a new composition PG emulsification MCT/LCT agent was performed, and measurement of the neutral fat, phosphatide, HDL cholesterol, AST, ALT, direct, and indirect bilirubin value was performed. As a result, an impaired liver function was prominent at the medication speed of 1.2g/kg/hr and 1.8g/kg/hr, and it turned out that optimal speed is 0.6g/kg/hr.

本研究采用PG （epikuron200和甘油复合的磷脂）乳化成磷脂酶DM（大豆卵磷脂）的新组合制剂，将MCT和LC按等量的1比1混合为中性脂肪的10%。采用Wistar系统4周龄雄性大鼠，采用含新组合物PG乳化MCT/LCT剂的自维持静脉给药，测定中性脂肪、磷脂、HDL胆固醇、AST、ALT、直接、间接胆红素值。结果表明，在给药速度为1.2g/kg/hr和1.8g/kg/hr时，肝功能受损较为明显，最佳给药速度为0.6g/kg/hr。