Novel Methods for Herbicides Analysis Using Biomimetic Materials

使用仿生材料分析除草剂的新方法

• 批准号: 09555257
• 负责人: TAKEUCHI Toshifumi
• 金额: $ 8万
• 依托单位: Hiroshima City University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09555257/
• 关键词: Molecular Imprinting; Molecular recognition; Dummy molecular Imprinting; Solid phase extraction; Artificial receptor; トリアジン系除草剤; ダミーインプリントポリマー; 農薬; 充填剤; Combinatorial Chemistry

In this study, artificial receptors synthesized by molecular imprinting were applied as separation media for solid phase extraction to develop new analytical systems for target agricultural chemicals. An automated system for molecularly imprinted polymer synthesis and evaluation was developed in 1997-1998, and it appeared that a combinatorial approach was suitable for the optimization of reaction conditions and functional monomer selection in molecularly imprinted polymer synthesis. During 1999-2000, the adaptation for the real sample was tried. The procedure of affinity solid phase extraction of atrazine residue in river water and soil was examined, and it was finally established as a reliable method. It became clear that atrazine which could not be removed in the preparation stage leaked out during solid phase extraction when atrazine was used as a template molecules and it affected the results of analysis. This problem was overcome by using dummy template molecule in the preparation stage instead of atrazine such as alkyl melamine derivatives.

本研究以分子印迹技术合成的人工受体作为固相萃取分离介质，开发了目标农药的分析新体系。1997-1998年，一个自动化系统的分子印迹聚合物的合成和评价，它出现了一个组合的方法是适合于分子印迹聚合物合成的反应条件和功能单体的选择优化。在1999-2000年期间，尝试了对真实的样本的改编。研究了亲和固相萃取法测定河水和土壤中阿特拉津残留的方法。阿特拉津作为模板分子在固相萃取过程中，由于阿特拉津在制备阶段不能被去除，导致阿特拉津的泄漏，影响了分析结果。通过在制备阶段使用虚拟模板分子代替莠去津如烷基三聚氰胺衍生物克服了这个问题。

项目成果

Toshifumi Takeuchi,Daigo Fukuma,and Jun Matui: "Combinatorial Molecular Imprinting:An Approach to Synthetic Polymer Receptors" ANALYTICAL CHEMISTRY. Volume 71,Number 2. 285-290 (1999)

Toshifumi Takeuchi、Daigo Fukuma 和 Jun Matui：“组合分子印迹：合成聚合物受体的方法”分析化学。

Matsui, J., Fujiwara, K., Takeuchi, T.: "Atrazine-Selective Polymers Prepared by Molecular Imprinting of Trialkylmelamines as Dummy Template Species of Atrazine"Anal.Chem.. 72. 1810-1813 (2000)

Matsui，J.，Fujiwara，K.，Takeuchi，T.：“通过三烷基三聚氰胺的分子印迹作为莠去津的虚拟模板物种制备莠去津选择性聚合物”Anal.Chem.. 72. 1810-1813 (2000)

Matsui,J., Kubo,H., Takeuchi,T.: "Design and Preparation of Molecular Imprinted Atrazine-Receptor. Polymers : Investigation of Functional Monomers and Solvents"Anal. Sci.. 14. 699-702 (1998)

Matsui,J.、Kubo,H.、Takeuchi,T.：“分子印迹莠去津受体的设计和制备。聚合物：功能单体和溶剂的研究”分析。

Matsui,J.,Fujiwara,K.,Takeuchi,T.: "Atrazine-Selective Polymers Prepared by Molecular Imprinting of Trialkylmelamines as Dummy Template Species of Atrazine"Analytical Chemistry. 72. 1810-1813 (2000)

Matsui，J.，Fujiwara，K.，Takeuchi，T.：“通过三烷基三聚氰胺的分子印迹作为莠去津的虚拟模板种类制备莠去津选择性聚合物”分析化学。

Matsui,J.,Fujiwara,K.,Ugata,S.,Takeuchi,T.: "Solid Phase Extraction with a Dibutylmelamine-imprinted Polymer as Triazine Herbicide-selective Sorbent"Journal of Chromatography A. 889. 25-31 (2000)

Matsui,J.、Fujiwara,K.、Ugata,S.、Takeuchi,T.：“用二丁基三聚氰胺印迹聚合物作为三嗪除草剂选择性吸附剂进行固相萃取”色谱杂志 A. 889. 25-31 (2000)