Synergetic Molecular Recognition Sites having a Signaling Function Prepared by Molecular Imprinting

以可聚合的金属卟啉和/或甲基丙烯酸为功能单体(S)，制备了杂环化合物的信号印迹聚合物，并通过层析、Scatchard分析和光谱分析对其进行了表征。在聚合物中，金属卟啉残基和甲基丙烯酸残基在印迹结合位协同工作。印迹聚合物的UV-Vis吸光度与目标浓度的对数呈线性关系，表明该聚合物可作为特定目标分子的选择性传感材料。不同的金属卟啉可以用作功能化单体，以便为能够与金属卟啉配位的广泛的目标化合物制备信号印迹聚合物。

Signaling-imprinted polymers were prepared for heterocyclic compounds using a polymerizable metalloporphyrin and/or methacrylic acid as functional monomer(s), and evaluated by chromatographic tests, Scatchard analysis, and spectroscopic analysis. In the polymers, the metalloporphyrin residue and methacrylic acid residues worked cooperatively at the imprinted binding site. A linear relationship was observed between the UV-Vis absorbance of the imprinted polymer and the logarithm of target concentrations, indicating that the polymer may be used as a selective sensing material for the given target molecule. Various metalloporphyrins can be used as functionalized monomers in order to prepare signaling-imprinted polymers for a wide range of target compounds capable of coordination with metalloporphyrins.