Synergetic Molecular Recognition Sites having a Signaling Function Prepared by Molecular Imprinting

分子印迹制备的具有信号传导功能的协同分子识别位点

• 批准号: 15510102
• 负责人: TAKEUCHI Toshifumi
• 金额: $ 2.43万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15510102/
• 关键词: molecular imprinting; molecular recognition; シナジェティックシグナリング材料

Signaling-imprinted polymers were prepared for heterocyclic compounds using a polymerizable metalloporphyrin and/or methacrylic acid as functional monomer(s), and evaluated by chromatographic tests, Scatchard analysis, and spectroscopic analysis. In the polymers, the metalloporphyrin residue and methacrylic acid residues worked cooperatively at the imprinted binding site. A linear relationship was observed between the UV-Vis absorbance of the imprinted polymer and the logarithm of target concentrations, indicating that the polymer may be used as a selective sensing material for the given target molecule. Various metalloporphyrins can be used as functionalized monomers in order to prepare signaling-imprinted polymers for a wide range of target compounds capable of coordination with metalloporphyrins.

以可聚合的金属卟啉和/或甲基丙烯酸为功能单体(S)，制备了杂环化合物的信号印迹聚合物，并通过层析、Scatchard分析和光谱分析对其进行了表征。在聚合物中，金属卟啉残基和甲基丙烯酸残基在印迹结合位协同工作。印迹聚合物的UV-Vis吸光度与目标浓度的对数呈线性关系，表明该聚合物可作为特定目标分子的选择性传感材料。不同的金属卟啉可以用作功能化单体，以便为能够与金属卟啉配位的广泛的目标化合物制备信号印迹聚合物。

项目成果

Synthesis of an extended hexagonal molecule as a highly symmetrical ligand

• DOI: 10.1016/j.tetlet.2005.01.014
• 发表时间: 2005-03
• 期刊: Tetrahedron Letters
• 影响因子: 1.8
• 作者: M. Takase;A. Nakajima;T. Takeuchi

Chiral recognition of octadentate Na+ complex with tetra-armed cyclen by molecularly imprinted polymers

• DOI: 10.1016/s0003-2670(03)00952-8
• 发表时间: 2004-02
• 期刊: Analytica Chimica Acta
• 影响因子: 6.2
• 作者: H. Kubo;Tomoko N Player;S. Shinoda;H. Tsukube;H. Nariai;T. Takeuchi

Chiral Recognition of Octadentate Na+ Complex with Tetra-Armed Cyclen by Molecular Imprinted Polymers

分子印迹聚合物对八齿钠配合物与四臂循环的手性识别

• 发表时间: 2004
• 期刊: Anal.Chim.Acta 504
• 作者: Kubo;H.;Player;T.N.;Shinoda;S.;Tsukube;H.;Nariai;H.;Takeuchi;T.
• 通讯作者: T.

Covalent Molecular Imprinting of Bisphenol A Using Its Diesters Followed by the Reductive Cleavage with LiAlH_4

双酚 A 双酯共价分子印迹，然后用 LiAlH_4 还原裂解

• 发表时间: 2004
• 期刊: J.Chromatogr.B 804
• 作者: Ikegami;T.;Lee;W.-S.;Nariai;H.;Takeuchi;T.
• 通讯作者: T.

Atrazine Tranformation Using Synthetic Enzymes Prepared by Molecular Imprinting

利用分子印迹制备的合成酶转化莠去津

• 发表时间: 2004
• 期刊: Org.Biomol.Chem.2004 2
• 作者: Takeuchi;T.;Ugata;S.;Masuda;S.;Matsui;J.;Yane;T.;Takase;M.
• 通讯作者: M.