Surface treatment of titanium implants by discharging methods

钛种植体的放电法表面处理

• 批准号: 14370644
• 负责人: MIYAZAKI Takashi
• 金额: $ 5.82万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370644/
• 关键词: titanium; discharging; implant; surface treatment; 生体適合性

Titanium has been well-established as a primary metallic biomaterial for use in dental implant systems. It has been reported that biocompatibility of titanium could be increased by various surface treatments. The aim of this study was to investigate whether the discharging methods are available for increasing biocompatibility of titanium implants. Results demonstrated that glow discharging plasma treatment enhanced initial adhesion of osteoblastic cells onto titanium surface through an integrin mediated mechanism. A discharging in modified artificial body fluid allowed a functionally gradient bone-like hydroxyapatite coating on titanium with micro meter order thickness. Further, titanium plates anodized by discharging in NaCl solution could acquire not only excelled antibacterial activity but also cell-compatibility. Thus we concluded that the discharging methods are available for use in surface treatment of titanium implants.

钛已被公认为用于牙科种植体系统的主要金属生物材料。据报道，钛的生物相容性可以通过各种表面处理来增加。本研究的目的是调查是否放电方法可提高钛种植体的生物相容性。结果表明，辉光放电等离子体处理通过整合素介导的机制增强成骨细胞在钛表面的初始粘附。在改性人工体液中放电，可在钛表面形成微米级厚度的功能梯度类骨羟基磷灰石涂层。此外，钛板在NaCl溶液中放电阳极氧化不仅可以获得优异的抗菌活性，而且细胞相容性。因此，我们得出结论，放电方法可用于钛植入物的表面处理。

项目成果

Y.Shibata, M.Hosaka, H.Kawai, T.Miyazaki: "Glow Discharge Plasma Treatment of Titanium Plates Enhances Adhesion of Osteoblast-like Cells to the Plates Through thelntegrin-Mediated Mechanism"Int J Oral Maxillofac Implants. 17(6). 771-777 (2002)

Y.Shibata、M.Hosaka、H.Kawai、T.Miyazaki：“钛板的辉光放电等离子体处理通过整合素介导的机制增强成骨细胞样细胞对板的粘附”Int J Oral Maxillofac Implants。

Y.Shibata, H.Takashima, H.Yamamoto, T.Miyazaki: "Functionally Gradient Bonelike Hydroxiapatite Coating on a Titanium metal Substrate Created by Discharging Method in HBSS without Organic molecules"Int J Oral Maxillofac Implants. 19(2)(in press). (2004)

Y.Shibata、H.Takashima、H.Yamamoto、T.Miyazaki：“在不含有机分子的 HBSS 中通过放电方法在钛金属基底上形成功能性梯度骨状羟基磷灰石涂层”Int J Oral Maxillofac Implants。

H.Takashima, Y.Shibata, T.Y.Kim, T.Miyazaki: "Hydroxyapatite Coating on a Titanium Metal Substrate by a Discharging Method in Modified Artificial Body Fluid"The International Journal of Oral & Maxillofacial Implants. 19(1). 62-72 (2004)

H.Takashima、Y.Shibata、T.Y.Kim、T.Miyazaki：“通过改性人工体液中的放电方法在钛金属基底上涂覆羟基磷灰石”国际口腔杂志

Y.Shibata, H.Kawai, H.Yamamoto, T.Igarashi, T.Miyazaki: "Antibacterial Titanium Plate Anodized by being discharged in NaCl Solution Exhibits Cell Compatibility"J Dent Res. 83(2). 115-119 (2004)

Y.Shibata、H.Kawai、H.Yamamoto、T.Igarashi、T.Miyazaki：“通过在 NaCl 溶液中放电进行阳极氧化处理的抗菌钛板表现出电池兼容性”J Dent Res。

Y.Shibata, H.Takashima, H.Yamamoto, T.Miyazaki: "Functionally Gradient Bonelike Hydroxiapatite Coating on a Titanium metal Substrate Created by Discharging Method in HBSS Without Organic molecules"The International Journal of Oral & Maxillofacial Implants

Y.Shibata、H.Takashima、H.Yamamoto、T.Miyazaki：“在不含有机分子的 HBSS 中通过放电方法在钛金属基底上形成功能性梯度骨状羟基磷灰石涂层”国际口腔杂志