Immediate loading titanium implant with hybrid structure prepared by discharging methods

放电法制备混合结构即刻负重钛种植体

• 批准号: 16390563
• 负责人: MIYAZAKI Takashi
• 金额: $ 6.21万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2005
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16390563/
• 关键词: Titanium; Implant; Surface modifications; Discharging; Immediate loading; コーティング

This study aimed to achieve immediate lading as well as long-term clinical success of titanium implants by means of surface modifications. Immediate loading of titanium implants strongly depends on its mechanical stability in a bone cavity. Titanium implants should be fixed with an appropriate torque. Thus, to prevent detaching of modified surface, surface modifications should be prepared as thin as possible. To prevent detaching of coating surface, the surface of titanium implants were modified by high- osteoconductive calcium phosphate nano-particles. The coating surface demonstrated a favorable bone-replacement in vivo. On the other hand, since titanium implants penetrate not only one but also gingival, implant surface should be modified to achieve antibacterial activity as well as osteocondcuctivity. We demonstrated that titanium surface anodized by being discharged in NaCl solution could achieve high antibacterial activity against oral bacteria as well as excellent cell-compatibility. It can be assumed that this technique well contribute in long-term clinical success of titanium implants. These newly surface modification techniques might have key role in further clinical stage.

这项研究旨在通过表面修饰实现钛植入物的立即提单以及长期临床成功。钛植入物的立即加载很大程度上取决于其在骨腔中的机械稳定性。钛植入物应以适当的扭矩固定。因此，为防止修饰的表面脱离，应尽可能薄地进行表面修饰。为了防止涂层脱离，钛植入物的表面是通过高骨连导钙钙纳米粒子修饰的。涂层表面在体内表现出良好的骨骼替代。另一方面，由于钛植入物不仅穿透一种而且渗透牙龈，因此应修改植入物表面以实现抗菌活性以及骨接收性。我们证明，通过在NaCl溶液中排出而阳极氧化的钛表面可以实现对口腔细菌的高抗菌活性以及出色的细胞兼容性。可以假定，该技术在钛植入物的长期临床成功方面做出了良好贡献。这些新的表面修饰技术可能在进一步的临床阶段起关键作用。

项目成果

Titanium Plate Anodized by Discharging Exhibits Antibacterial Activity Against Oral Bacteria

经放电阳极氧化处理的钛板具有针对口腔细菌的抗菌活性

• 发表时间: 2005
• 期刊: The 4^<th> Annual Meeting of Pan-Pacific Implant Society
• 作者: Deng J.;Arimoto T.;Shibata Y.;Kawai H.;Yamamoto M.;Miyazaki T.;Ikarashi T.
• 通讯作者: Ikarashi T.

Colloidal β-tricalciumphosphate prepared by discharging in modified body fluid facilitates synthesis of collagen composite.

在改性体液中放电制备的胶体β-磷酸三钙有利于胶原复合物的合成。

• 发表时间: 2005
• 期刊: Journal of Dental Research 84(in press)
• 作者: Y.Shibata;H.Yamamoto;T.Miyazaki
• 通讯作者: T.Miyazaki

Titanium Plant Anodized by Discharging Exhibits Antibacterial Activity Against Oral Bacteria.

通过放电阳极氧化的钛植物具有针对口腔细菌的抗菌活性。

• 发表时间: 2005
• 期刊: The 4^<th> Annual Meeting of Pan-Pacific Implant Society
• 作者: Deng J.;Arimoto T.;Shibata T.;Kawai H.;Ymamoto M.;Miyazaki T.;Ikarashi T.
• 通讯作者: Ikarashi T.

Antibacterial titanium plate anodized by discharging in NaCl solution exhibits cell-compatibility.

通过在氯化钠溶液中放电进行阳极氧化处理的抗菌钛板表现出电池相容性。

• 发表时间: 2004
• 期刊: Journal of Dental Research 83
• 作者: Y.Shibata;H.Kawai;H.Yamamoto;T.Igarashi;T.Miyazaki
• 通讯作者: T.Miyazaki

In vivo performance of two different hydroxyapatite coatings on titanium prepared by discharging in electrolyte

电解液放电制备的两种不同钛表面羟基磷灰石涂层的体内性能

• 发表时间: 2006
• 期刊: J Biomed Mater Res B Appl Biomater 76B(in press)
• 作者: Hiroki Yamamoto;Yo Shibata;Takashi Miyazaki
• 通讯作者: Takashi Miyazaki