Immediate loading titanium implant with hybrid structure prepared by discharging methods

本研究旨在通过表面修饰来实现钛种植体的即刻加载和长期临床成功。钛种植体的即刻负荷很大程度上取决于其在骨腔中的机械稳定性。钛种植体应以适当的扭矩固定。因此，为防止改性表面脱落，应尽可能薄地制备表面改性。为防止涂层表面脱落，采用高导骨性纳米磷酸钙颗粒对钛种植体表面进行改性。涂层表面在体内表现出良好的骨替代作用。另一方面，由于钛种植体不仅能穿透一个种植体，而且还能穿透牙周，因此种植体表面应该进行修饰，以达到抗菌和骨连接的目的。我们证明，在氯化钠溶液中放电的钛表面可以达到很高的抗菌活性，同时具有良好的细胞相容性。可以认为，这项技术对钛种植体的长期临床成功有很好的贡献。这些新的表面修饰技术可能会在进一步的临床阶段发挥关键作用。

This study aimed to achieve immediate lading as well as long-term clinical success of titanium implants by means of surface modifications. Immediate loading of titanium implants strongly depends on its mechanical stability in a bone cavity. Titanium implants should be fixed with an appropriate torque. Thus, to prevent detaching of modified surface, surface modifications should be prepared as thin as possible. To prevent detaching of coating surface, the surface of titanium implants were modified by high- osteoconductive calcium phosphate nano-particles. The coating surface demonstrated a favorable bone-replacement in vivo. On the other hand, since titanium implants penetrate not only one but also gingival, implant surface should be modified to achieve antibacterial activity as well as osteocondcuctivity. We demonstrated that titanium surface anodized by being discharged in NaCl solution could achieve high antibacterial activity against oral bacteria as well as excellent cell-compatibility. It can be assumed that this technique well contribute in long-term clinical success of titanium implants. These newly surface modification techniques might have key role in further clinical stage.