Immediate loading of titanium implant achieved by nano surface modifications

通过纳米表面修饰实现钛植入物的即时负载

• 批准号: 18390523
• 负责人: MIYAZAKI Takashi
• 金额: $ 7.34万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390523/
• 关键词: Titanium; Immediate loading; Implant; 表面処理; ナノ

This study aimed to achieve immediate loading as well as long-term clinical success of titanium implants by means of surface modifications. Immediate loading of titanium implants strongly depends on its mechanical stability in a bone cavity. Titanium implants should be fixed with an appropriate torque. Thus, to prevent detaching of modified surface, surface modifications should be prepared as thin as possible. To prevent detaching of coating surface, the surface of titanium implants were modified by high- osteoconductive calcium phosphate nano-particles. The coating surface demonstrated a favorable bone-replacement in vivo. On the other hand, since titanium implants penetrate not only one but also gingival, implant surface should be modified to achieve antibacterial activity as well as osteo coductivity. We demonstrated that titanium surface anodized by being discharged in NaC1 solution could achieve high antibacterial activity against oral bacteria as well as excellent cell-compatibility. It can be assumed that this technique well contribute in long-term clinical success of titanium implants. These newly surface modification techniques might have key role in further clinical stage.

本研究旨在通过表面修饰来实现钛种植体的即刻加载和长期临床成功。钛种植体的即刻负荷很大程度上取决于其在骨腔中的机械稳定性。钛种植体应以适当的扭矩固定。因此，为防止改性表面脱落，应尽可能薄地制备表面改性。为防止涂层表面脱落，采用高导骨性纳米磷酸钙颗粒对钛种植体表面进行改性。涂层表面在体内表现出良好的骨替代作用。另一方面，由于钛种植体不仅可以穿透一个种植体，而且还可以穿透牙周，因此种植体表面应该进行修饰，以达到抗菌活性和骨传导性。结果表明，钛表面在氯化钠溶液中放电处理后，不仅具有良好的细胞相容性，而且对口腔细菌具有较高的抗菌活性。可以认为，这项技术对钛种植体的长期临床成功有很好的贡献。这些新的表面修饰技术可能会在进一步的临床阶段发挥关键作用。

项目成果

Swain, Micro mechanical property recovery of human carious dentin achieved with colloidal 13-tricalcium phosphate

Swain，用胶体 13-磷酸三钙实现人类龋齿牙本质的微机械性能恢复

• 发表时间: 2008
• 期刊: J Dent Res 87(3)
• 作者: Y.;Shibata;L.H.;He;Y. Kataoka;T.;Miyazaki;M.V
• 通讯作者: M.V

Osteoblast-like cell proliferation on tape-cast and sintered tricalcium phosphate sheets

• DOI: 10.1016/j.actbio.2007.10.001
• 发表时间: 2008-03-01
• 期刊: ACTA BIOMATERIALIA
• 影响因子: 9.7
• 作者: Tanimoto, Yasuhiro;Shibata, Yo;Nishiyama, Norihiro
• 通讯作者: Nishiyama, Norihiro