Immediate loading of titanium implant achieved by nano surface modifications

通过纳米表面修饰实现钛植入物的即时负载

• 批准号: 18390523
• 负责人: MIYAZAKI Takashi
• 金额: $ 7.34万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18390523/
• 关键词: Titanium; Immediate loading; Implant; 表面処理; ナノ

This study aimed to achieve immediate loading as well as long-term clinical success of titanium implants by means of surface modifications. Immediate loading of titanium implants strongly depends on its mechanical stability in a bone cavity. Titanium implants should be fixed with an appropriate torque. Thus, to prevent detaching of modified surface, surface modifications should be prepared as thin as possible. To prevent detaching of coating surface, the surface of titanium implants were modified by high- osteoconductive calcium phosphate nano-particles. The coating surface demonstrated a favorable bone-replacement in vivo. On the other hand, since titanium implants penetrate not only one but also gingival, implant surface should be modified to achieve antibacterial activity as well as osteo coductivity. We demonstrated that titanium surface anodized by being discharged in NaC1 solution could achieve high antibacterial activity against oral bacteria as well as excellent cell-compatibility. It can be assumed that this technique well contribute in long-term clinical success of titanium implants. These newly surface modification techniques might have key role in further clinical stage.

这项研究旨在通过表面修饰实现钛植入物的立即加载以及长期临床成功。钛植入物的立即加载很大程度上取决于其在骨腔中的机械稳定性。钛植入物应以适当的扭矩固定。因此，为防止修饰的表面脱离，应尽可能薄地进行表面修饰。为了防止涂层脱离，钛植入物的表面是通过高骨连导钙钙纳米粒子修饰的。涂层表面在体内表现出良好的骨骼替代。另一方面，由于钛植入物不仅渗透到牙龈上，而且渗透牙龈，因此应修改植入物表面以实现抗菌活性以及骨质代码。我们证明，通过在NAC1溶液中排出而阳极氧化的钛表面可以实现对口腔细菌的高抗菌活性以及出色的细胞兼容性。可以假定，该技术在钛植入物的长期临床成功方面做出了良好贡献。这些新的表面修饰技术可能在进一步的临床阶段起关键作用。

项目成果

Swain, Micro mechanical property recovery of human carious dentin achieved with colloidal 13-tricalcium phosphate

Swain，用胶体 13-磷酸三钙实现人类龋齿牙本质的微机械性能恢复

• 发表时间: 2008
• 期刊: J Dent Res 87(3)
• 作者: Y.;Shibata;L.H.;He;Y. Kataoka;T.;Miyazaki;M.V
• 通讯作者: M.V