Remineralization of preliminarily carious by enamel proteins with artificial body fluids

人工体液通过牙釉质蛋白对初步龋齿进行再矿化

• 批准号: 23659924
• 负责人: MIYAZAKI Takashi
• 金额: $ 2.33万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659924/
• 关键词: エナメル質; 初期齲蝕; 再石灰化; エナメル; 再生; バイオメカニクス; エナメルタンパク

Background: Management of human teeth has moved from a surgical to a more conservative approach of inhibiting or preventing lesion progression. Increasing enamel mineralization is crucial in this regard. A potential difficulty is the preferential mineralization of the outermost portion of the enamel that can prevent overall mineralization. We describe a strategy for increasing the mineralization potential of dental enamel. Extracted human premolar teeth enamel were exposed to a high concentration of hydrogen peroxide with an energizing source. Samples were stored in artificial saliva at 37uC for 1 wk. A desktop X-ray micro-CT system was used to evaluate the mineral density of samples. Mineral distribution was polarized between the lower and the higher mineralized portion of enamel by charged oxygen free radicals due to activation of permeated hydrogenperoxide. The kinetics of energy absorption in the deeper enamel region demonstrated improvement of preferential mineralization into the region without restricting overall mineralization of the enamel. Subsequent increasing mineralization, even in the dense mineralized outer portion of enamel, was also achieved. This increased mineralization may promote resistance to acidic deterioration of the structure. The present study is one of the primary steps towards the development of novel application in reparative and restorative dentistry.

背景：人类牙齿的治疗已经从外科手术转向更保守的方法，以抑制或防止病变进展。增加牙釉质矿化在这方面是至关重要的。一个潜在的困难是牙釉质最外层的优先矿化会阻碍整体矿化。我们描述了一种增加牙釉质矿化潜力的策略。提取的人类前磨牙牙釉质暴露在高浓度过氧化氢的激励源。样品在37℃的人工唾液中保存1周。采用台式x射线微ct系统对样品进行了矿物密度评价。由于渗透过氧化氢的活化，带电荷的氧自由基使釉质矿化程度较低和较高的部分之间的矿物分布发生极化。深层牙釉质区域的能量吸收动力学表明，在不限制牙釉质整体矿化的情况下，优先矿化进入该区域。随后增加的矿化，即使在致密矿化外层的牙釉质，也实现了。这种增加的矿化可以增强结构对酸性变质的抵抗力。本研究是在牙医学修复和修复中开发新应用的主要步骤之一。

项目成果

Tape-cast and sintered β-tricalcium phosphate laminates for biomedical applications: Effect of milled Al2_O_3 fiber additives on microstructural and mechanical properties

用于生物医学应用的流延和烧结 β-磷酸三钙层压板：研磨 Al2_O_3 纤维添加剂对微观结构和机械性能的影响

• 发表时间: 2012
• 期刊: Journal of Biomedical Materials Research Part B: Applied Biomaterials
• 作者: Tanimoto Y.;Teshima M.;Nishiyama N.;Yamaguchi M.;Hirayama S.;Shibata Y.;Miyazaki T.
• 通讯作者: Miyazaki T.

A new modified laser pretreatment for porcelain zirconia bonding

• DOI: 10.1016/j.dental.2013.03.002
• 发表时间: 2013-05-01
• 期刊: DENTAL MATERIALS
• 影响因子: 5
• 作者: Liu, Dan;Matinlinna, Jukka P.;Kan, Chi-Wai
• 通讯作者: Kan, Chi-Wai

Antioxidant and osteogenic properties of anodically oxidized titanium

• DOI: 10.1016/j.jmbbm.2012.01.016
• 发表时间: 2012-09-01
• 期刊: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
• 影响因子: 3.9
• 作者: Iwai-Yoshida, Misato;Shibata, Yo;Miyazaki, Takashi
• 通讯作者: Miyazaki, Takashi

Physical properties of sintered tricalcium phosphate laminates with addition of milled Al_2O_3-fibers

添加磨碎Al_2O_3纤维的烧结磷酸三钙层压板的物理性能

• 发表时间: 2011
• 作者: Yasuhiro Tanimoto;Ryoichiro Uchida;Hideki Teshima;Norihiro Nishiyama;Yo Shibata;Takashi Miyazaki
• 通讯作者: Takashi Miyazaki

The in vitro characteristics of anodically oxidized titanium

阳极氧化钛的体外特性

• 发表时间: 2011
• 作者: M.Iwai-Yoshida;Y.Shibata;Y.Tanimoto;H.Nakano;K.Maki;T.Miyazaki
• 通讯作者: T.Miyazaki