Remineralization of preliminarily carious by enamel proteins with artificial body fluids

人工体液通过牙釉质蛋白对初步龋齿进行再矿化

• 批准号: 23659924
• 负责人: MIYAZAKI Takashi
• 金额: $ 2.33万
• 依托单位: Showa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659924/
• 关键词: エナメル質; 初期齲蝕; 再石灰化; エナメル; 再生; バイオメカニクス; エナメルタンパク

Background: Management of human teeth has moved from a surgical to a more conservative approach of inhibiting or preventing lesion progression. Increasing enamel mineralization is crucial in this regard. A potential difficulty is the preferential mineralization of the outermost portion of the enamel that can prevent overall mineralization. We describe a strategy for increasing the mineralization potential of dental enamel. Extracted human premolar teeth enamel were exposed to a high concentration of hydrogen peroxide with an energizing source. Samples were stored in artificial saliva at 37uC for 1 wk. A desktop X-ray micro-CT system was used to evaluate the mineral density of samples. Mineral distribution was polarized between the lower and the higher mineralized portion of enamel by charged oxygen free radicals due to activation of permeated hydrogenperoxide. The kinetics of energy absorption in the deeper enamel region demonstrated improvement of preferential mineralization into the region without restricting overall mineralization of the enamel. Subsequent increasing mineralization, even in the dense mineralized outer portion of enamel, was also achieved. This increased mineralization may promote resistance to acidic deterioration of the structure. The present study is one of the primary steps towards the development of novel application in reparative and restorative dentistry.

背景：人类牙齿的管理已从外科手术转变为抑制或预防病变进展的更保守的方法。在这方面，增加搪瓷矿化至关重要。潜在的困难是搪瓷最外部部分的优先矿化，可以防止总体矿化。我们描述了提高牙齿牙釉质矿化潜力的策略。提取的人类前牙搪瓷暴露于高浓度的过氧化氢，并具有通电源。样品在37uc的人造唾液中存储1周。使用桌面X射线微型CT系统来评估样品的矿物质密度。矿物质分布在下部和较高的矿物质搪瓷部分之间通过带电的氧气自由基激活，这是由于渗透的氢氧化物的激活而极化。深层搪瓷区域中能量吸收的动力学表明，在不限制牙釉质的总体矿化的情况下，优先矿化对区域的优先矿化有所改善。随后的矿化也增加了，即使在搪瓷的密集矿化外部也是如此。这种增加的矿化可能会促进对结构酸性恶化的抗性。本研究是在修复和恢复牙科中开发新应用的主要步骤之一。

项目成果

Tape-cast and sintered β-tricalcium phosphate laminates for biomedical applications: Effect of milled Al2_O_3 fiber additives on microstructural and mechanical properties

用于生物医学应用的流延和烧结 β-磷酸三钙层压板：研磨 Al2_O_3 纤维添加剂对微观结构和机械性能的影响

• 发表时间: 2012
• 期刊: Journal of Biomedical Materials Research Part B: Applied Biomaterials
• 作者: Tanimoto Y.;Teshima M.;Nishiyama N.;Yamaguchi M.;Hirayama S.;Shibata Y.;Miyazaki T.
• 通讯作者: Miyazaki T.

A new modified laser pretreatment for porcelain zirconia bonding

• DOI: 10.1016/j.dental.2013.03.002
• 发表时间: 2013-05-01
• 期刊: DENTAL MATERIALS
• 影响因子: 5
• 作者: Liu, Dan;Matinlinna, Jukka P.;Kan, Chi-Wai
• 通讯作者: Kan, Chi-Wai

Antioxidant and osteogenic properties of anodically oxidized titanium

• DOI: 10.1016/j.jmbbm.2012.01.016
• 发表时间: 2012-09-01
• 期刊: JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
• 影响因子: 3.9
• 作者: Iwai-Yoshida, Misato;Shibata, Yo;Miyazaki, Takashi
• 通讯作者: Miyazaki, Takashi

ナノインデンターによるエナメル質の物理的評価

使用纳米压痕仪对牙釉质进行物理评估

• 发表时间: 2012
• 作者: 山口幹代;野杁由一郎;田中玲奈
• 通讯作者: 田中玲奈

In vitro demineralization of tooth enamel subjected to two whitening regimes

两种美白方案对牙釉质的体外脱矿作用

• 发表时间: 2013
• 期刊: The Journal of The American Dental Association
• 作者: Ogura K,Tanaka R;Shibata Y;Miyazaki T;Hisamitsu H
• 通讯作者: Hisamitsu H