A cross-sectional study of early effects on the lung in workers exposed to indium, a suspected strong inducer of pneumoritis

一项关于接触铟（一种疑似肺炎强诱因）的工人对肺部早期影响的横断面研究

• 批准号: 15390191
• 负责人: OMAE Kazuyuki
• 金额: $ 5.06万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15390191/
• 关键词: indium.; respiratory effects; cross-sectional study; interstitial pneumonitis; emphysema; high resolution computed tomography; KL-6; spirometry; 肺線維化; 肺気腫化; 高分解能CT撮影(HRCT); 努力性肺活量

To clarify the effects of indium (In) on the respiratory system, a cross-sectional study was performed in 2 indium-tin oxide ceramics target (ITO target) manufacturing plants and 2 indium recycling plants in December 2003 and February 2004. The study subjects were 112 male indium-exposed workers (In workers, mean exposure duration : 70.3 mos), 40 male former exposed workers (ex-In workers, mean exposure duration : 71.7 mos, mean duration after indium exposure : 74.1 mos), and 104 male referent workers. Nine female In workers, 2 female former In workers, and 25 female referent workers were also surveyed.Geometric means of serum In concentration (In-S) in In workers, ex-In workers and referent workers were 6.87, 2.96 and 0.52 μg/L, respectively. Prevalence of "cough other than winter" in smokers and "cough in winter" and "phlegm in winter" in non-smokers were significantly higher in In workers than in referent workers. Indices of spirometry didn't show any differences. Prevalence of inte … More rstitial changes in 6 lung fields examined by high resolution computed tomography (HRCT) was ca. 23% in ex-In workers, but no statistical difference was seen between In workers and referent workers. Dose-response relationship between In-S and the prevalence of the interstitial changes was unclear. Serum KL-6, SP-D and SP-A increased dose-dependently and very sharp dose-effect and dose-response relationships were revealed between In-S and KL-6. Some ex-In workers showed high In-S and KL-6 even 150 months after finishing their In exposure job.In conclusion, it became clear that In had a strong potential to induce lung interstitial changes and KL-6 in serum was the most appropriate indicator of the interstitial changes. Furthermore, the effects of In seem to persist for a long time even after finishing the exposure.According to these study results, health risks due to In exposure were communicated to the managers of the plants and individual workers in 2004. Health risk management for control the workplace environment and protecting the health effects on the lung were also recommend. Less

为了阐明铟（In）对呼吸系统的影响，我们于2003年12月和2004年2月在2家氧化铟锡陶瓷靶材（ITO靶材）生产厂和2家铟回收厂进行了横断面研究。研究对象为112名男性铟暴露工人（In工人，平均暴露时间：70.3 mos）， 40名男性前暴露工人（前In工人，平均暴露时间：71.7 mos，铟暴露后平均暴露时间：74.1 mos）和104名男性参照工人。调查对象还包括9名女性员工、2名女性前员工和25名女性员工。In工人、前In工人和参比工人血清In浓度（In- s）几何平均值分别为6.87、2.96和0.52 μg/L。吸烟职工“非冬咳嗽”、非吸烟职工“冬咳嗽”、“冬痰”患病率明显高于对照工。肺活量测定指标差异无统计学意义。高分辨率计算机断层扫描（HRCT）检查的6个肺野的患病率约为23%，但在工人和参照工人之间没有统计学差异。In-S与间质改变发生率之间的剂量-反应关系尚不清楚。血清KL-6、SP-D和SP-A呈剂量依赖性升高，且In-S与KL-6之间存在非常明显的剂量效应和剂量反应关系。一些曾经从事过In暴露工作的人，在结束工作150个月后，In- s和KL-6仍然很高。综上所述，In具有很强的诱导肺间质改变的潜力，血清中KL-6是肺间质改变最合适的指标。此外，即使在完成曝光后，紫外线的影响似乎仍会持续很长时间。根据这些研究结果，2004年已向工厂的管理人员和个别工人通报了因接触氟氯化碳而造成的健康风险。还建议进行健康风险管理，以控制工作场所环境和保护对肺部的健康影响。少

项目成果

Toxicity of bismuth and indium, substitute metals for lead-free solder

铋和铟的毒性，无铅焊料的替代金属

• 发表时间: 2002
• 期刊: Occupational Health Journal(in Japanese) 25
• 作者: Sano Y;Omae K.
• 通讯作者: Omae K.

Miyaki K, Hosoda K, Hirata M, Tanaka A, Nishiwaki Y, Takebayashi T, Inoue N, Omae K.: "Biological monitoring of indium using graphite furnace atomic absorption spectrophotometry in workers exposed to particles of indium compounds."Journal of Occupational

Miyaki K、Hosoda K、Hirata M、Tanaka A、Nishiwaki Y、Takebayashi T、Inoue N、Omae K.：“使用石墨炉原子吸收分光光度法对暴露于铟化合物颗粒的工人进行铟的生物监测。”职业杂志

Usefulness of examining KL-6, SP-D, and SP-A in serum in occupational health settings

在职业健康环境中检查血清中 KL-6、SP-D 和 SP-A 的有用性

• 发表时间: 2004
• 期刊: Occupational Health Journal(in Japanese) 27
• 作者: Hamaguchi T;Omae K.
• 通讯作者: Omae K.

Biological monitoring of indium using graphite furnace atomic absorption spectrophotometry in workers exposed to particles of indium compounds

使用石墨炉原子吸收分光光度法对接触铟化合物颗粒的工人进行铟的生物监测

• 发表时间: 2003
• 期刊: Journal of Occupational Health 45
• 作者: Miyaki K;Hosoda K;Hirata M;Tanaka A;Nishiwaki Y;Takebayashi T;Inoue N;Omae K.
• 通讯作者: Omae K.

KL-6, SP-D, SP-Aの産業医学における有用性

KL-6、SP-D、SP-A 在工业医学中的用途

• 发表时间: 2004
• 期刊: 産業医学ジャーナル 27
• 作者: 浜口伝博;大前和幸
• 通讯作者: 大前和幸