Molecular epidemiology on distribution of new human malaria parasite and G6PD deficiency

在缅甸、越南、柬埔寨、印度尼西亚和泰国进行了疟疾和G6PD缺乏的分子流行病学调查。利用从这些国家收集的疟原虫和卵形疟原虫的野生分离株，对这些寄生虫和G6PD缺乏症型进行了分子检测。(1)在缅甸，Kalow、Pindaya、Pyin Oo Lyin、Than Dwe、Tathon等城镇发现了许多新的疟疾和卵圆疟原虫病例。G6PD缺乏症以Mahidol型为主。(2)在印度尼西亚，莫米尔、恩德、索、奥博博、肯达鲁伊和马纳多等地发现了许多新的疟疾伴虫病例。另外还检出2例新的卵圆静脉曲张。在印度尼西亚发现了6种以上的G6PD缺乏症。(3)在柬埔寨，马德望省和腊塔纳基里省以及越南林同省保洛省发现了许多新的疟疾伴虫病例。在这两个国家发现了许多新的疟虫病例。在柬埔寨，所有的G6PD型都是Viangchan型，而在越南，检测到许多来自中国的类型。(4)在泰国的Sankaburi进行了调查，还发现了几例新的疟疾假体和1例新的卵圆形假体。G6PD亏虚型多为强禅型。上述结果表明，新型人疟寄生虫在东南亚地区分布广泛。此外，G6PD缺乏症的Viangchan型主要分布在泰国和柬埔寨，而缅甸的优势型为Mahidol型，两者与印度尼西亚和越南的分布模式不同。

Molecular epidemiological surveys on malaria and G6PD deficiency were performed in Myanmar, Vietnam, Cambodia, Indonesia and Thailand. Using wild isolates of the new human parasites of P.malariae and P.ovale collected from these countries, these parasites and G6PD deficiency types were examined molecularly.(1)In Myanmar, many cases of new P.malariae and P.ovale were detected from towns, such as Kalow, Pindaya, Pyin Oo Lyin, Than Dwe, Tathon. In G6PD deficiency, the Mahidol type was dominant.(2)In Indonesia, many cases of new P.malariae were detected from Maumere, Ende, Soe, Oebobo, Kendarui and Manado. Two cases of new P.ovale were also detected. More than 6 types of G6PD deficiency were found from Indonesia.(3)In Cambodia, many cases of new P.malariae were detected from Battambang and Rattanakiri Provinces as well as from Bao Loc, Lam Dong Province, Vietnam. Many cases of new P.malariae were detected from these two countries. In Cambodia, all of G6PD type was Viangchan, whereas in Vietnam many types of Chinese origin were detected.(4)In Thailand, survey was conducted at Sankaburi, and several cases of new P.malariae and one case of new P.ovale were also detected. Almost of G6PD deficiency types were Viangchan type.These above results may indicate that the new human malaria parasites are distributing widely in SE Asia. In addition, the Viangchan type of G6PD deficiency is distributing mainly in Thailand and Cambodia, whereas in Myanmar dominant type is the Mahidol type, both of which differed from distribution patterns in Indonesia and Vietnam.