Molecular epidemiology on distribution of new human malaria parasite and G6PD deficiency

在缅甸、越南、柬埔寨、印度尼西亚和泰国进行了疟疾和G6PD缺乏症的分子流行病学调查。利用从这些国家采集的新的人疟原虫和卵形疟原虫的野生分离株，对这些寄生虫和G6PD缺乏型进行了分子检测。(1)在缅甸，从卡洛、平达亚、平吴莱因等城镇发现了许多新的疟疾和卵形疟原虫病例，而在DWE、Tathon等城镇发现了许多新的疟疾和卵形疟原虫病例。G6PD缺乏症以Mahidol型为主。(2)在印度尼西亚，在Maumere、Ende、Soe、Oebobo、Kendarui和Manado发现了许多新的疟疾病例。还发现了两例新的卵形螺旋体。在柬埔寨，马德望省、腊塔纳基里省以及越南林东省的宝洛发现了许多新的疟疾病例。在这两个国家发现了许多新的疟疾病例。在柬埔寨，G6PD血型均为Viangchan血型，而在越南，发现许多中国血型。(4)在泰国，在Sankaburi进行了调查，还发现了几例新的疟原虫和一例新的卵形疟原虫。G6PD缺乏型以Viangchan型为主，提示新的人疟原虫在东南亚有广泛的分布。此外，旺昌型G6PD缺乏症主要分布在泰国和柬埔寨，而缅甸的优势型是Mahidol型，这两种类型在印度尼西亚和越南的分布模式都不同。

Molecular epidemiological surveys on malaria and G6PD deficiency were performed in Myanmar, Vietnam, Cambodia, Indonesia and Thailand. Using wild isolates of the new human parasites of P.malariae and P.ovale collected from these countries, these parasites and G6PD deficiency types were examined molecularly.(1)In Myanmar, many cases of new P.malariae and P.ovale were detected from towns, such as Kalow, Pindaya, Pyin Oo Lyin, Than Dwe, Tathon. In G6PD deficiency, the Mahidol type was dominant.(2)In Indonesia, many cases of new P.malariae were detected from Maumere, Ende, Soe, Oebobo, Kendarui and Manado. Two cases of new P.ovale were also detected. More than 6 types of G6PD deficiency were found from Indonesia.(3)In Cambodia, many cases of new P.malariae were detected from Battambang and Rattanakiri Provinces as well as from Bao Loc, Lam Dong Province, Vietnam. Many cases of new P.malariae were detected from these two countries. In Cambodia, all of G6PD type was Viangchan, whereas in Vietnam many types of Chinese origin were detected.(4)In Thailand, survey was conducted at Sankaburi, and several cases of new P.malariae and one case of new P.ovale were also detected. Almost of G6PD deficiency types were Viangchan type.These above results may indicate that the new human malaria parasites are distributing widely in SE Asia. In addition, the Viangchan type of G6PD deficiency is distributing mainly in Thailand and Cambodia, whereas in Myanmar dominant type is the Mahidol type, both of which differed from distribution patterns in Indonesia and Vietnam.