Development of hand-guided measurement device of stapes mobility using the micromachining technique

利用微加工技术开发镫骨活动度手动测量装置

• 批准号: 11557124
• 负责人: WADA Hiroshi
• 金额: $ 6.4万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11557124/
• 关键词: Middle Ear; Ossicular Chain; Motility; Measurement; Transmission Factor; Tympanoplasty; Micromachine

The ossicular chain, consisting of the malleus, incus and stapes, plays an important role in auditory mechanics. If some part of the ossicles becomes fixed, hearing loss occurs. In order to improve the level of hearing, the fixated part is replaced with a prosthesis. This surgery is called "tympanoplasty." It is important to evaluate the stapes mobility during the tympanoplasty, because it affects the prognosis of improvement of the hearing level. However, objective measurement of stapes mobility has not yet to be achieved.In this study, an apparatus which is clinically useful for measuring the stapes mobility based on the method of Wada et al. (2000) was developed by assembling a small-sized force sensor and a high-precision actuator, and its clinical applicability was evaluated by measuring stapes mobility in the guinea pig. The following conclusions can be drawn.1. Miniaturization of the apparatus was realized by the use of a small-sized capacitive force sensor and a hydraulic micromanipulator with a flexible coil rod and wires. Owing to this technology, the stapes mobility is measurable during surgery without impairing the sensitivity and repeatability.2. The equivalent stiffness of the normal stapes in guinea pigs was 17±3 N/m (N = 5).3. The difference between the stiffness of the normal stapes and that of the artificially fixed stapes which corresponds to the symptom of otosclerosis was clearly distinguished. Therefore, the new apparatus developed in this study would be helpful for diagnosing stapes fixation.

听骨链由锤骨、砧骨和镫骨组成，在听觉力学中起着重要作用。如果听小骨的某一部分固定不动，就会发生听力损失。为了提高听力水平，固定部分被替换为假体。这种手术被称为“鼓室成形术。“在鼓室成形术中评估镫骨活动度是很重要的，因为它影响听力水平改善的预后。然而，镫骨活动度的客观测量尚未实现，在本研究中，通过组装小型力传感器和高精度致动器，开发了基于Wada等人（2000）的方法的临床上有用的用于测量镫骨活动度的装置，并通过测量豚鼠的镫骨活动度来评估其临床适用性。可以得出以下结论。1.该装置的小型化是通过使用一个小型的电容式力传感器和一个液压显微操作器与柔性线圈杆和电线。由于这项技术，镫骨活动度是可测量的，在手术过程中，而不损害灵敏度和可重复性。正常豚鼠镫骨的等效刚度为17±3 N/m（N = 5）.正常镫骨的僵硬度与人工固定镫骨对应的耳硬化症的僵硬度之间的差异被清楚地区分开来。因此，本研究所开发的新仪器将有助于诊断镫骨固定。

项目成果

Hiroshi Wada, Takuji Koike, Yu Yuasa, Tetsuaki Kawase, Hiroaki Fujii: "Measurement of stapes mobility in guinea pigs and rabbits"Hearing Research. 154. 158-164 (2000)

Hiroshi Wada、Takuji Koike、Yuasa、Tetsuaki Kawase、Hiroaki Fujii：“豚鼠和兔子镫骨活动度的测量”听力研究。

Hiroshi Wada, Takuji Koike, Yu Yuasa, Tetsuaki Kawase, and Hiroaki Fujii: "Measurement of stapes mobility in guinea pigs and rabbits."Hearing Research. 154. 158-164 (2000)

Hiroshi Wada、Takuji Koike、Yuasa、Tetsuaki Kawase 和 Hiroaki Fujii：“豚鼠和兔子镫骨活动度的测量。”听力研究。

Hiroshi Wada: "Measurement of stapes mobility in guinea pigs and rabbits"Hearing Research. (in press).

Hiroshi Wada：“豚鼠和兔子镫骨活动度的测量”听力研究。