Development of the program for analysis of the dynamic behavior of the organ of Corti

柯蒂氏器动态行为分析程序的开发

• 批准号: 13557142
• 负责人: WADA Hiroshi
• 金额: $ 8.7万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557142/
• 关键词: cochlea; organ of Corti; dynamic behavior; FEM; fluid-structure interaction; 聴覚; 有限要素法; 流体構造相関問題

The organ of Corti (OC) in the cochlea transforms sounds into action potentials in auditory nerve fibers. As the extreme vulnerability to trauma exhibited by the cochlea prevents the experimental observation that could confirm the inherence in this process, the two-dimensional finite-element model of the OC was constructed. Using this model, the dynamic behavior of the OC was analyzed.As the DC is immersed in lymph fluid, the interaction between the OC and the lymph fluid must be taken into account when the dynamic behavior of the OC and fluid pressure distribution are numerically analyzed. However, the complex structure of the OC and the large difference in material properties between the fluid and the structure of the OC complicate modeling of the lymph-OC interaction using commercially available FEN applications. Therefore, the original program was developed to consider the fluid-structure interaction.When a fluid pressure fluctuation is induced by vibration of the stapes, two types … More of pressure waves occur in the cochlea. As the OC is driven by these pressure waves, it is important to understand their frequency characteristics. However, there have been no reports on empirical observations of these waves, because of the difficulty of measuring them independently. Using the model, the magnitude and phase of the fast and slow waves were predicted so as to fit the numerically obtained pressure distribution in the scala tympani with that of the intracochlea pressure measurement. Next, the dynamic behavior of the OC was analyzed when these predicted pressures were applied to the OC. The following conclusions can be drawn:1. The magnitude of the fast wave increases with increasing frequency for the entire frequency range. The magnitude of the slow wave increases gradually with increasing frequency until it reaches a maximum at the characteristic frequency (CF), and it then falls sharply.2. The OC shows a rotational movement around the end of the modiolus side of the basilar membrane. Less

耳蜗中的柯蒂氏器 (OC) 将声音转化为听觉神经纤维中的动作电位。由于耳蜗极易受到创伤，因此无法进行实验观察来证实这一过程的内在性，因此构建了 OC 的二维有限元模型。利用该模型对OC的动态行为进行了分析。由于DC浸入淋巴液中，因此在对OC的动态行为和流体压力分布进行数值分析时必须考虑OC与淋巴液之间的相互作用。然而，OC 的复杂结构以及流体和 OC 结构之间材料特性的巨大差异使得使用商用 FEN 应用程序对淋巴-OC 相互作用的建模变得复杂。因此，最初的程序是为了考虑流体-结构相互作用而开发的。当镫骨振动引起流体压力波动时，耳蜗中会出现两种类型的压力波。由于 OC 是由这些压力波驱动的，因此了解它们的频率特性非常重要。然而，由于独立测量这些波的困难，还没有关于这些波的实证观察的报道。使用该模型，预测快波和慢波的幅度和相位，以使数值获得的鼓阶压力分布与耳蜗内压力测量的压力分布相匹配。接下来，当这些预测压力施加到 OC 时，分析了 OC 的动态行为。得出以下结论： 1．在整个频率范围内，快波的幅度随着频率的增加而增加。慢波的幅度随着频率的增加而逐渐增大，直到在特征频率（CF）处达到最大值，然后急剧下降。2． OC 显示围绕基底膜轴侧末端的旋转运动。较少的