Development of the program for analysis of the dynamic behavior of the organ of Corti

耳蜗中的Corti （OC）器官将声音转化为听觉神经纤维中的动作电位。由于耳蜗极易受到创伤，因此无法通过实验观察来证实这一过程的内在性，因此构建耳蜗二维有限元模型。利用该模型对混凝土的动力特性进行了分析。由于直流管浸没在淋巴液中，在数值分析直流管的动力行为和流体压力分布时，必须考虑直流管与淋巴液的相互作用。然而，淋巴管的复杂结构以及流体和淋巴管结构之间材料性质的巨大差异使得使用市面上可用的FEN应用程序来模拟淋巴管-淋巴管相互作用变得复杂。因此，开发了考虑流固耦合的原始程序。当镫骨振动引起流体压力波动时，耳蜗中会出现两种类型的压力波。由于OC是由这些压力波驱动的，因此了解它们的频率特性非常重要。然而，由于难以独立测量这些引力波，还没有关于这些引力波的经验观测报告。利用该模型预测了快慢波的大小和相位，使数值计算得到的鼓室内压力分布与耳蜗内压力测量结果相拟合。接下来，分析了当这些预测压力施加于OC时OC的动态行为。可以得出以下结论：1。在整个频率范围内，快波的大小随频率的增加而增加。随着频率的增加，慢波的振幅逐渐增大，直到在特征频率处达到最大值，然后急剧下降。OC在基底膜动肌侧末端显示旋转运动。少

The organ of Corti (OC) in the cochlea transforms sounds into action potentials in auditory nerve fibers. As the extreme vulnerability to trauma exhibited by the cochlea prevents the experimental observation that could confirm the inherence in this process, the two-dimensional finite-element model of the OC was constructed. Using this model, the dynamic behavior of the OC was analyzed.As the DC is immersed in lymph fluid, the interaction between the OC and the lymph fluid must be taken into account when the dynamic behavior of the OC and fluid pressure distribution are numerically analyzed. However, the complex structure of the OC and the large difference in material properties between the fluid and the structure of the OC complicate modeling of the lymph-OC interaction using commercially available FEN applications. Therefore, the original program was developed to consider the fluid-structure interaction.When a fluid pressure fluctuation is induced by vibration of the stapes, two types … More of pressure waves occur in the cochlea. As the OC is driven by these pressure waves, it is important to understand their frequency characteristics. However, there have been no reports on empirical observations of these waves, because of the difficulty of measuring them independently. Using the model, the magnitude and phase of the fast and slow waves were predicted so as to fit the numerically obtained pressure distribution in the scala tympani with that of the intracochlea pressure measurement. Next, the dynamic behavior of the OC was analyzed when these predicted pressures were applied to the OC. The following conclusions can be drawn:1. The magnitude of the fast wave increases with increasing frequency for the entire frequency range. The magnitude of the slow wave increases gradually with increasing frequency until it reaches a maximum at the characteristic frequency (CF), and it then falls sharply.2. The OC shows a rotational movement around the end of the modiolus side of the basilar membrane. Less