Development of the program for analysis of the dynamic behavior of the organ of Corti

柯蒂氏器动态行为分析程序的开发

基本信息

  • 批准号:
    13557142
  • 负责人:
  • 金额:
    $ 8.7万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2001
  • 资助国家:
    日本
  • 起止时间:
    2001 至 2002
  • 项目状态:
    已结题

项目摘要

The organ of Corti (OC) in the cochlea transforms sounds into action potentials in auditory nerve fibers. As the extreme vulnerability to trauma exhibited by the cochlea prevents the experimental observation that could confirm the inherence in this process, the two-dimensional finite-element model of the OC was constructed. Using this model, the dynamic behavior of the OC was analyzed.As the DC is immersed in lymph fluid, the interaction between the OC and the lymph fluid must be taken into account when the dynamic behavior of the OC and fluid pressure distribution are numerically analyzed. However, the complex structure of the OC and the large difference in material properties between the fluid and the structure of the OC complicate modeling of the lymph-OC interaction using commercially available FEN applications. Therefore, the original program was developed to consider the fluid-structure interaction.When a fluid pressure fluctuation is induced by vibration of the stapes, two types … More of pressure waves occur in the cochlea. As the OC is driven by these pressure waves, it is important to understand their frequency characteristics. However, there have been no reports on empirical observations of these waves, because of the difficulty of measuring them independently. Using the model, the magnitude and phase of the fast and slow waves were predicted so as to fit the numerically obtained pressure distribution in the scala tympani with that of the intracochlea pressure measurement. Next, the dynamic behavior of the OC was analyzed when these predicted pressures were applied to the OC. The following conclusions can be drawn:1. The magnitude of the fast wave increases with increasing frequency for the entire frequency range. The magnitude of the slow wave increases gradually with increasing frequency until it reaches a maximum at the characteristic frequency (CF), and it then falls sharply.2. The OC shows a rotational movement around the end of the modiolus side of the basilar membrane. Less
耳蜗中的Corti器官(OC)将声音转化为听神经纤维中的动作电位。由于耳蜗对创伤表现出的极端脆弱性,阻碍了能够证实这一过程的内在规律的实验观察,因此构建了OC的二维有限元模型。由于DC浸泡在淋巴流体中,在数值分析OC的动态行为和流体压力分布时,必须考虑OC与淋巴流体之间的相互作用。然而,OC的复杂结构以及流体和OC结构之间的材料性质的巨大差异使得使用商业上可用的FEN应用来模拟淋巴-OC相互作用变得复杂。因此,最初的程序是为了考虑流固耦合作用。当由砧骨的振动引起流体压力波动时,两种类型的…更多的压力波发生在耳蜗处。由于OC是由这些压力波驱动的,因此了解其频率特性是很重要的。然而,由于很难独立测量,目前还没有关于这些波的经验观测的报告。利用该模型预测了快波和慢波的大小和相位,以使数值计算得到的鼓阶内压力分布与耳廓内压力测量结果相吻合。其次,分析了当这些预测压力施加到OC时,OC的动态行为。得出以下结论:1.在整个频率范围内,快波的大小随着频率的增加而增大。慢波的幅度随着频率的增加而逐渐增大,直到在特征频率(Cf)处达到最大值,然后急剧下降。OC绕着基底膜的蜗侧末端旋转运动。较少

项目成果

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WADA Hiroshi其他文献

みちのくの仏像と東北における仏像表現の受容
陆奥的佛像与东北地区佛像表现的接受
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    ABE Hisashi ;WATANABE Ken;ISHIKAWA Atsuko;NOSHIRO Shuichi;FUJII Tomoyuki;IWASA Mitsuharu;KANEKO Hiroyuki;WADA Hiroshi;山盛弥生;宮下 修一;村田雄二郎;Tatsuya Higaki;笠原一人;牧山康志;山盛弥生;山根聡;西木政統;笠原一人;石井剛;太田佳鈴;松村耕光;Mikio Nakahara;加藤尚武;平子友長;丸山士郎
  • 通讯作者:
    丸山士郎
蘭渓道隆の頂相―建仁寺西来院調査報告を中心に
兰溪道流的巅峰:以建仁寺西雷院调查报告为中心
  • DOI:
  • 发表时间:
    2014
  • 期刊:
  • 影响因子:
    0
  • 作者:
    ABE Hisashi ;WATANABE Ken;ISHIKAWA Atsuko;NOSHIRO Shuichi;FUJII Tomoyuki;IWASA Mitsuharu;KANEKO Hiroyuki;WADA Hiroshi;山盛弥生;宮下 修一;村田雄二郎;Tatsuya Higaki;笠原一人;牧山康志;山盛弥生;山根聡;西木政統;笠原一人;石井剛;太田佳鈴;松村耕光;Mikio Nakahara;加藤尚武;平子友長;丸山士郎;太田佳鈴;平子友長;TONAGA Yasushi;郡司ペギオ幸夫;浅見龍介
  • 通讯作者:
    浅見龍介
National Wealth without military strength?: The Four Postwar Eras in Modern East Asia
国家财富没有军事实力?
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    ABE Hisashi ;WATANABE Ken;ISHIKAWA Atsuko;NOSHIRO Shuichi;FUJII Tomoyuki;IWASA Mitsuharu;KANEKO Hiroyuki;WADA Hiroshi;山盛弥生;宮下 修一;村田雄二郎
  • 通讯作者:
    村田雄二郎
Technical Examination of Medals of Christian Relics preserved by TNM.
对 TNM 保存的基督教文物奖章进行技术检查。
Non-destructive method for species identification of historical wooden artifacts using NIR spectroscopy: separation of softw
使用近红外光谱法对历史木制文物进行物种鉴定的无损方法:软件分离
  • DOI:
  • 发表时间:
    2015
  • 期刊:
  • 影响因子:
    0
  • 作者:
    ABE Hisashi ;WATANABE Ken;ISHIKAWA Atsuko;NOSHIRO Shuichi;FUJII Tomoyuki;IWASA Mitsuharu;KANEKO Hiroyuki;WADA Hiroshi
  • 通讯作者:
    WADA Hiroshi

WADA Hiroshi的其他文献

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{{ truncateString('WADA Hiroshi', 18)}}的其他基金

Challenges of visualizing the conformational changes of prestin using an atomic force microscope equipped with a membrane potential control device
使用配备膜电位控制装置的原子力显微镜观察 prestin 构象变化的挑战
  • 批准号:
    23659790
  • 财政年份:
    2011
  • 资助金额:
    $ 8.7万
  • 项目类别:
    Grant-in-Aid for Challenging Exploratory Research
Correlation between expression of exocrine progenitor genes and cancer stem cells in pancreatic cancer.
胰腺癌中外分泌祖基因表达与癌症干细胞的相关性。
  • 批准号:
    22591519
  • 财政年份:
    2010
  • 资助金额:
    $ 8.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Molacular evolutionary background of the innovations of deuterostome morphologo
后口动物形态创新的分子进化背景
  • 批准号:
    21370105
  • 财政年份:
    2009
  • 资助金额:
    $ 8.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Ring-shaped chalkiness increased by dry wind in rice : Direct measurement of turgor in endosperm cells and the role of osmotic adjustment at low water potential
水稻因干燥风而增加的环状垩白度:直接测量胚乳细胞的膨压和低水势下渗透调节的作用
  • 批准号:
    21380017
  • 财政年份:
    2009
  • 资助金额:
    $ 8.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Creation of a New Method to Refold the Membrane Protein Mutants for Curing of Hereditary Hearing Loss
创建一种膜蛋白突变体重折叠治疗遗传性听力损失的新方法
  • 批准号:
    20390439
  • 财政年份:
    2008
  • 资助金额:
    $ 8.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Structural and functional analysis of the motor protein prestin using purified protein
使用纯化蛋白对运动蛋白 prestin 进行结构和功能分析
  • 批准号:
    18390455
  • 财政年份:
    2006
  • 资助金额:
    $ 8.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Structural analysis of the motor protein prestin
运动蛋白 prestin 的结构分析
  • 批准号:
    15086202
  • 财政年份:
    2003
  • 资助金额:
    $ 8.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
Biomechanics at Micro- and Nanoscale Levels
微米和纳米级生物力学
  • 批准号:
    15086101
  • 财政年份:
    2003
  • 资助金额:
    $ 8.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research on Priority Areas
Research on construction of a theory about redevelopment of the exhibition and preservation space for the cultural property in a historic buildings.
历史建筑文化财产展示与保护空间再开发理论构建研究
  • 批准号:
    14209021
  • 财政年份:
    2002
  • 资助金额:
    $ 8.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (A)
Research on evolution of larval skeleton in sea urchin: Echinometridae
海胆:棘螈科幼虫骨骼进化研究
  • 批准号:
    13839008
  • 财政年份:
    2001
  • 资助金额:
    $ 8.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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Reconstruction of three-dimensional organ of Corti micromechanical motion patterns via optical coherence tomography
光学相干断层扫描重建三维Corti器官微机械运动模式
  • 批准号:
    10533408
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  • 批准号:
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Role of Organ of Corti Outer Hair Cell/Vibration Hot Spots in Distortion Product Otoacoustic Emission Generation
柯蒂氏器外毛细胞/振动热点在失真产物耳声发射产生中的作用
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表观遗传机制触发发育中的柯蒂器官的分化和可塑性
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3D functional changes in the gap junctional signaling during the age related neurodegeneration in the mammalian inner ear Organ of Corti
哺乳动物内耳柯蒂氏器年龄相关神经变性过程中间隙连接信号的 3D 功能变化
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Exploration of the role of caveolin in the organ of Corti
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