Development of measurement system for basilar membrane vibrations using a laser Doppler vibrometer coupled to a microscope.

使用与显微镜耦合的激光多普勒振动计开发基底膜振动测量系统。

• 批准号: 04557074
• 负责人: WADA Hiroshi
• 金额: $ 6.21万
• 依托单位: Tohoku University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Developmental Scientific Research (B)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-04557074/
• 关键词: Measurements; Laser Doppler vibrometer; Vibrations; Basilar membrane; Amplification; Cochlea; Otoacoustic emissions; レーザドップラ; 顕微鏡; レードドップラ

Although amplitude of tympanic membranc vibrations is only a few nanometer when we talk in a low voice, we can understand clearly what they say. This is speculated to be caused by cochlear amplification. Otoacoustic Emissions (OAEs) are recognized as the byproduct of this cochlear amplication. However, mechanism of the amplification in the cochlea is obscure. Therefore, in this paper, cochlear basilar membrane vibrations of guinea pigs in live, dead, hypoxia conditions and when OAEs are generated using a laser Doppler vibrometer coupled to a compound microscope, and an attempt is made to clarify the mechanism of the cochlear amplification and its contribution toward the generation of OAEs. As the results of the measurements of basilar membrane vibrations in live, dead and hypoxia conditions, it is guessed that cochlear amplifier exists in the live guinea pigs and has nonlinearity and is influenced by the moderated hypoxia. Furthermore, simultaneous measurements of basilar membrane vibrations and OAEs suggest that cochlear nonlincar amplification contributes toward the origin of OAEs.

当我们低声说话时，虽然鼓膜振动的幅度只有几个纳米，但我们可以清楚地理解他们所说的话。据推测这是由耳蜗放大引起的。耳声发射（OAE）被认为是耳蜗放大的副产品。然而，耳蜗放大的机制尚不清楚。因此，在本文中，耳蜗基底膜振动的豚鼠在活的，死亡的，缺氧的条件下，当OAE产生使用激光多普勒振动仪耦合到一个复合显微镜，并试图阐明耳蜗放大的机制和它对OAE的产生的贡献。根据活体、死亡和低氧条件下的基底膜振动测量结果，推测耳蜗放大器存在于活体豚鼠体内，并具有非线性特性，受中度低氧的影响。此外，同时测量基底膜振动和耳声发射表明，耳蜗非线性放大有助于耳声发射的起源。

项目成果

和田 仁: "レーザドップラ振動計と複合顕微鏡の組み合わせによる内耳蝸牛内基底振動の計測" 日本機械学会誌. (発表予定).

Hitoshi Wada：“使用激光多普勒振动计和复合显微镜测量内耳耳蜗的基础振动”，日本机械工程师学会杂志（预定演讲）。

Hiroshi Wada: "Measurements of cochlear basilar membrane vibrations using a laser Doppler vibrometer coupled to a compound microscope" JSME. (Submitting).

Hiroshi Wada：“使用激光多普勒振动计与复合显微镜测量耳蜗基底膜振动”JSME。

和田 仁: "レーザドップラ振動計による基底板振動の計測" 日本聴覚医学会誌. (発表予定).

Hitoshi Wada：“使用激光多普勒振动计测量基底板振动”，日本听力学会杂志（待出版）。

Hiroshi Wada: "Measurements of basilar membrane vibrations using laser Doppler vibrometer" Audiology Japan. (Submitting).

Hiroshi Wada：“使用激光多普勒振动计测量基底膜振动”日本听力学。