Correlation between expression of exocrine progenitor genes and cancer stem cells in pancreatic cancer.

胰腺癌中外分泌祖基因表达与癌症干细胞的相关性。

• 批准号: 22591519
• 负责人: WADA Hiroshi
• 金额: $ 2.83万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591519/
• 关键词: 膵臓外科学; 膵癌; 癌幹細胞; 膵内分泌腫瘍; progenitor gene; 転写因子; Progenitor gene; Pdx1; proeniter gene

We evaluated the expression of exocrine progenitor genes and cancerstem cells markers in pancreatic cancer. CD44-positive cells were enriched after preoperative chemo-radiation therapy (CRT). Pdx1 positive tumors tended to limit to pancreas after CRT. There was no correlation between expression of Pdx1 and CD44. CD44-positive tumors without expression of Pdx1 were poor prognosis. These results suggested that transfection of exocrine progenitor genes may decrease its malignant behavior in pancreatic cancer.

我们评估了胰腺癌外分泌祖细胞基因和肿瘤干细胞标记物的表达。CD44阳性细胞在术前放化疗（CRT）后富集。CRT后Pdx 1阳性肿瘤有局限于胰腺的趋势。Pdx 1与CD 44的表达无相关性。CD44阳性而不表达Pdx 1者预后差。这些结果表明，转染外分泌祖基因可能会降低胰腺癌的恶性行为。

项目成果

A case report of port-site metastasis of pancreatic cancer after laparoscope assistted distalpancreatectomy

腹腔镜辅助远端胰腺切除术后胰腺癌端口转移一例报告

• 发表时间: 2011
• 期刊: Gan To Kagaku Ryoho
• 作者: Koga C;Tanemura M;Wada H;Kobayashi S;Marubashi S;Eguchi H;Mori M;Doki Y;Nagano H
• 通讯作者: Nagano H

Ep-CAM is a significant prognostic factor in pancreatic cancer patients by suppressing cell activity

• DOI: 10.1038/onc.2011.59
• 发表时间: 2011-08-01
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Akita, H.;Nagano, H.;Doki, Y.
• 通讯作者: Doki, Y.

Arterial Stimulation and Venous Sampling for Glucagonomas of the Pancreas

• DOI: 10.5754/hge11392
• 发表时间: 2012-01-01
• 期刊: HEPATO-GASTROENTEROLOGY
• 作者: Eguchi, Hidetoshi;Tanemura, Masahiro;Nagano, Hiroaki
• 通讯作者: Nagano, Hiroaki

A case report of total remnant pancreatectomy for ductal carcinoma after distal pancreatectomy for invasive intraductal papillary mucinous carcinoma

侵袭性导管内乳头状粘液癌远端胰腺切除术后全残胰切除术治疗导管癌一例报告

• 发表时间: 2012
• 期刊: Gan To Kagaku Ryoho
• 作者: Okubo K;Hama N;Kobayashi S;Eguchi H;Akita H;Wada H;Kawamoto K;Marubashi S;Tanemura M;Umeshita K;Mori M;Doki Y;Nagano H
• 通讯作者: Nagano H

膵癌細胞株におけるgemcitabine耐性とmicroRNA-181b との検討

胰腺癌细胞系中吉西他滨耐药性和 microRNA-181b 的检查

• 发表时间: 2011
• 作者: 瀧内 大輔;江口 英利;和田 浩志;川本 弘一;小林 省吾;丸橋 繁;種村 匡弘;永野 浩昭;森 正樹;土岐 祐一郎
• 通讯作者: 土岐 祐一郎