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Study on genetic and environmental factors of the etiology of incurable and serious neurological diseases in West New Guinea

西新几内亚疑难及严重神经系统疾病病因的遗传和环境因素研究

基本信息

批准号：
11691212
负责人：
SEGUCHI Harumichi
金额：
$ 3.84万
依托单位：
KOCHI MEDICAL SCHOOL
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2000
项目状态：
已结题

项目摘要

The amyotorophic lateral sclerosis (ALS) and Parkinsonism-dementia (PD), specific incurable and serious neurological diseases, are known to be found together in unusually high incidence in Guam and New Guinea Island. Gajdusek surveyed in the southern coastal plain of West New Guinea of Indonesia form 1963 to 1985, and reported that the incidence of these diseases were extraordinarily high among the Auyu and Asmat peoples of the Edera and Obaa Kecamatans (administrative districts) near Merauke. Since then, repeated surveillances have been planned in these areas, however, they could not be performed because of the political problems and the underdeveloped atmosphere in these areas. We recognized the fact that these incurable and serious neurological diseases, ALS and PD, were still encountered many cases, when we surveyed from 1999 to 2000 in Bade and Kepi village and their suburb in the southern low marsh tropical forest plain of Irian Jaya Province of Indonesia, West New Guinea. Throug … More h the resident medical examination we found that the only one new case of ALS had appeared, but the prevalence of traumatic myelopathy and Parkinsonism had recorded extraordinarily high. However, we could not differentiate at that time whether these cases of Parkinsonism were combined with the dementia.We were able to clarify to some extent the environment of the medical condition, physical and psychological figures, and the cultural characteristics of the daily life sounding the resident of this area through the surveillance of the relationship between the aged condition and the genetic and environmental factors for this two years in the Irian Jaya Province of West New Guinea of Indonesia based at Wemena located in the central highland of this area. In the future we will try to clarify the etiology of ALS and PD, in the viewpoint of environmental factors related with the water examination, and further to clarify the real state of the cysticercosis encountered in high incidence in this area, by means of repeated surveillance by the Neurologist cooperated with the residential medical staffs. Less

肌萎缩侧索硬化症（ALS）和帕金森痴呆症（PD），具体的不可治愈的和严重的神经系统疾病，是已知的一起发现在异常高的发病率在关岛和新几内亚岛。Gajdusek于1963年至1985年在印度尼西亚西新几内亚南部沿海平原进行了调查，并报告说，这些疾病在Merauke附近Edera和Obaa Mamatans（行政区）的Auyu和Asmat人中的发病率非常高。自那时以来，曾多次计划在这些地区进行监测，但由于这些地区的政治问题和不发达的气氛而未能进行。1999 ~ 2000年在印度尼西亚西新几内亚伊里安查亚省南部低沼泽热带森林平原的Bade村和Kepi村及其郊区进行调查时，我们认识到这些不可治愈的严重神经系统疾病ALS和PD仍有许多病例。斯罗格 ...更多信息在住院医师体检中，我们发现只有一例ALS的新病例出现，但创伤性脊髓病和帕金森综合征的患病率却非常高。但是，当时我们无法区分这些帕金森综合征病例是否与痴呆症合并，我们能够在一定程度上澄清病情的环境、生理和心理数据，通过对该地区老年人衰老状况与遗传、环境因素关系的监测，印度尼西亚新几内亚西部的伊里安查亚省，位于该地区的中部高地。今后我们将从与水检查有关的环境因素的角度，通过神经科医师与驻地医务人员的反复监测，进一步阐明该地区高发病率囊虫病的真实的状态，以阐明ALS和PD的病因。少